(27 nodes) Platelet-derived growth factor receptor signaling pathway network (Ornithorhynchus anatinus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	F7B9D8_ORNAN	Uncharacterized protein. (599 aa)
	PLAT	Plasminogen activator, tissue type. (595 aa)
	F6QCH5_ORNAN	Uncharacterized protein. (68 aa)
	NR4A3	Nuclear receptor subfamily 4 group A member 3. (562 aa)
	PDGFRB	Platelet derived growth factor receptor beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1081 aa)
	PDGFRA	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (872 aa)
	VEGFA	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (215 aa)
	PDGFRL	Ig-like domain-containing protein. (260 aa)
	PTPN11	Uncharacterized protein. (368 aa)
	NRP1	Neuropilin; Belongs to the neuropilin family. (920 aa)
	ITGB3	Integrin beta; Belongs to the integrin beta chain family. (725 aa)
	PDGFB	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (212 aa)
	PTPRJ	Protein tyrosine phosphatase receptor type J. (1245 aa)
	PTPN1	Tyrosine-protein phosphatase non-receptor type. (376 aa)
	CSPG4	Uncharacterized protein. (445 aa)
	PDGFD	Platelet derived growth factor D. (340 aa)
	F6W8B0_ORNAN	Uncharacterized protein. (211 aa)
	SGPL1	Sphingosine-1-phosphate lyase 1. (584 aa)
	F6U1V6_ORNAN	Uncharacterized protein. (698 aa)
	F7AVI5_ORNAN	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (599 aa)
	ZFAND5	Zinc finger AN1-type containing 5. (213 aa)
	ARID5B	AT-rich interaction domain 5B. (1188 aa)
	PDGFC	Platelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (305 aa)
	F7EVB2_ORNAN	Protein kinase domain-containing protein. (142 aa)
	F6S0E0_ORNAN	Receptor protein-tyrosine kinase. (603 aa)
	K7E9F5_ORNAN	Arrestin_C domain-containing protein. (149 aa)
	K7EB87_ORNAN	Uncharacterized protein. (239 aa)

Your Current Organism:

Ornithorhynchus anatinus

NCBI taxonomy Id: 9258
Other names: O. anatinus, Platypus anatinus, duck-billed platypus, duckbill platypus, platypus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARID5B	ZFAND5	ENSOANP00000024022	ENSOANP00000020753	AT-rich interaction domain 5B.	Zinc finger AN1-type containing 5.	0.416
CSPG4	F6U1V6_ORNAN	ENSOANP00000015937	ENSOANP00000018024	Uncharacterized protein.	Uncharacterized protein.	0.922
CSPG4	K7EB87_ORNAN	ENSOANP00000015937	ENSOANP00000030794	Uncharacterized protein.	Uncharacterized protein.	0.946
CSPG4	PDGFRB	ENSOANP00000015937	ENSOANP00000003631	Uncharacterized protein.	Platelet derived growth factor receptor beta; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.603
F6S0E0_ORNAN	F6W8B0_ORNAN	ENSOANP00000027183	ENSOANP00000000252	Receptor protein-tyrosine kinase.	Uncharacterized protein.	0.517
F6S0E0_ORNAN	F7AVI5_ORNAN	ENSOANP00000027183	ENSOANP00000018314	Receptor protein-tyrosine kinase.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.517
F6S0E0_ORNAN	F7EVB2_ORNAN	ENSOANP00000027183	ENSOANP00000026114	Receptor protein-tyrosine kinase.	Protein kinase domain-containing protein.	0.899
F6S0E0_ORNAN	NRP1	ENSOANP00000027183	ENSOANP00000009660	Receptor protein-tyrosine kinase.	Neuropilin; Belongs to the neuropilin family.	0.524
F6S0E0_ORNAN	PDGFB	ENSOANP00000027183	ENSOANP00000010978	Receptor protein-tyrosine kinase.	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family.	0.824
F6S0E0_ORNAN	PDGFC	ENSOANP00000027183	ENSOANP00000024682	Receptor protein-tyrosine kinase.	Platelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family.	0.610
F6S0E0_ORNAN	PDGFD	ENSOANP00000027183	ENSOANP00000016594	Receptor protein-tyrosine kinase.	Platelet derived growth factor D.	0.498
F6S0E0_ORNAN	PDGFRB	ENSOANP00000027183	ENSOANP00000003631	Receptor protein-tyrosine kinase.	Platelet derived growth factor receptor beta; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.698
F6S0E0_ORNAN	PTPN11	ENSOANP00000027183	ENSOANP00000009592	Receptor protein-tyrosine kinase.	Uncharacterized protein.	0.517
F6S0E0_ORNAN	VEGFA	ENSOANP00000027183	ENSOANP00000006273	Receptor protein-tyrosine kinase.	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family.	0.434
F6U1V6_ORNAN	CSPG4	ENSOANP00000018024	ENSOANP00000015937	Uncharacterized protein.	Uncharacterized protein.	0.922
F6U1V6_ORNAN	K7EB87_ORNAN	ENSOANP00000018024	ENSOANP00000030794	Uncharacterized protein.	Uncharacterized protein.	0.945
F6U1V6_ORNAN	PDGFRB	ENSOANP00000018024	ENSOANP00000003631	Uncharacterized protein.	Platelet derived growth factor receptor beta; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.417
F6W8B0_ORNAN	F6S0E0_ORNAN	ENSOANP00000000252	ENSOANP00000027183	Uncharacterized protein.	Receptor protein-tyrosine kinase.	0.517
F6W8B0_ORNAN	F7EVB2_ORNAN	ENSOANP00000000252	ENSOANP00000026114	Uncharacterized protein.	Protein kinase domain-containing protein.	0.517
F6W8B0_ORNAN	K7E9F5_ORNAN	ENSOANP00000000252	ENSOANP00000030162	Uncharacterized protein.	Arrestin_C domain-containing protein.	0.667