(12 nodes) Insulin-like growth factor receptor signaling pathway network (Ornithorhynchus anatinus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	GIGYF1	GYF domain-containing protein. (136 aa)
	IGFBP5	IGFBP N-terminal domain-containing protein. (74 aa)
	PIK3R1	SH2 domain-containing protein. (230 aa)
	IGF1	Insulin like growth factor 1. (153 aa)
	PLCB1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1096 aa)
	TSC2	Uncharacterized protein. (625 aa)
	EIF2AK3	Eukaryotic translation initiation factor 2 alpha kinase 3. (1028 aa)
	K7E742_ORNAN	Tuberin domain-containing protein. (207 aa)
	IGF1R	Recep_L_domain domain-containing protein. (214 aa)
	K7EFR3_ORNAN	Uncharacterized protein. (637 aa)
	F6W873_ORNAN	Tyrosine-protein kinase receptor. (1150 aa)
	GRB10	Growth factor receptor bound protein 10. (596 aa)

Your Current Organism:

Ornithorhynchus anatinus

NCBI taxonomy Id: 9258
Other names: O. anatinus, Platypus anatinus, duck-billed platypus, duckbill platypus, platypus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EIF2AK3	GRB10	ENSOANP00000016419	ENSOANP00000000482	Eukaryotic translation initiation factor 2 alpha kinase 3.	Growth factor receptor bound protein 10.	0.519
F6W873_ORNAN	GRB10	ENSOANP00000000256	ENSOANP00000000482	Tyrosine-protein kinase receptor.	Growth factor receptor bound protein 10.	0.838
F6W873_ORNAN	IGF1R	ENSOANP00000000256	ENSOANP00000030177	Tyrosine-protein kinase receptor.	Recep_L_domain domain-containing protein.	0.900
F6W873_ORNAN	PIK3R1	ENSOANP00000000256	ENSOANP00000007081	Tyrosine-protein kinase receptor.	SH2 domain-containing protein.	0.588
GIGYF1	GRB10	ENSOANP00000029214	ENSOANP00000000482	GYF domain-containing protein.	Growth factor receptor bound protein 10.	0.699
GRB10	EIF2AK3	ENSOANP00000000482	ENSOANP00000016419	Growth factor receptor bound protein 10.	Eukaryotic translation initiation factor 2 alpha kinase 3.	0.519
GRB10	F6W873_ORNAN	ENSOANP00000000482	ENSOANP00000000256	Growth factor receptor bound protein 10.	Tyrosine-protein kinase receptor.	0.838
GRB10	GIGYF1	ENSOANP00000000482	ENSOANP00000029214	Growth factor receptor bound protein 10.	GYF domain-containing protein.	0.699
GRB10	IGF1R	ENSOANP00000000482	ENSOANP00000030177	Growth factor receptor bound protein 10.	Recep_L_domain domain-containing protein.	0.983
GRB10	PIK3R1	ENSOANP00000000482	ENSOANP00000007081	Growth factor receptor bound protein 10.	SH2 domain-containing protein.	0.722
IGF1	IGF1R	ENSOANP00000008847	ENSOANP00000030177	Insulin like growth factor 1.	Recep_L_domain domain-containing protein.	0.937
IGF1	IGFBP5	ENSOANP00000008847	ENSOANP00000005188	Insulin like growth factor 1.	IGFBP N-terminal domain-containing protein.	0.523
IGF1R	F6W873_ORNAN	ENSOANP00000030177	ENSOANP00000000256	Recep_L_domain domain-containing protein.	Tyrosine-protein kinase receptor.	0.900
IGF1R	GRB10	ENSOANP00000030177	ENSOANP00000000482	Recep_L_domain domain-containing protein.	Growth factor receptor bound protein 10.	0.983
IGF1R	IGF1	ENSOANP00000030177	ENSOANP00000008847	Recep_L_domain domain-containing protein.	Insulin like growth factor 1.	0.937
IGF1R	PIK3R1	ENSOANP00000030177	ENSOANP00000007081	Recep_L_domain domain-containing protein.	SH2 domain-containing protein.	0.957
IGF1R	PLCB1	ENSOANP00000030177	ENSOANP00000013374	Recep_L_domain domain-containing protein.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.	0.659
IGFBP5	IGF1	ENSOANP00000005188	ENSOANP00000008847	IGFBP N-terminal domain-containing protein.	Insulin like growth factor 1.	0.523
K7E742_ORNAN	K7EFR3_ORNAN	ENSOANP00000029349	ENSOANP00000032370	Tuberin domain-containing protein.	Uncharacterized protein.	0.928
K7E742_ORNAN	TSC2	ENSOANP00000029349	ENSOANP00000015844	Tuberin domain-containing protein.	Uncharacterized protein.	0.929