(67 nodes) Regulation of fibroblast proliferation network (Ornithorhynchus anatinus)

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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textmining

co-expression

protein homology

Your Input:
	F7EBG4_ORNAN	Phospholipase A(2). (144 aa)
	MED31	Mediator of RNA polymerase II transcription subunit 31; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (356 aa)
	DHX9	Uncharacterized protein. (1273 aa)
	NLRC3	NLR family CARD domain containing 3. (969 aa)
	FNDC3B	Fibronectin type III domain containing 3B. (1207 aa)
	IFI30	Uncharacterized protein. (261 aa)
	TP53INP1	Tumor protein p53 inducible nuclear protein 1. (235 aa)
	NDUFS4	NADH:ubiquinone oxidoreductase subunit S4. (180 aa)
	TRIM32	Tripartite motif containing 32. (642 aa)
	CD74	Thyroglobulin type-1 domain-containing protein. (259 aa)
	F6V4A8_ORNAN	CDC73_C domain-containing protein. (158 aa)
	CDC73	CDC73_N domain-containing protein. (258 aa)
	F6ZML7_ORNAN	Nuclear receptor domain-containing protein. (223 aa)
	F7B8L0_ORNAN	Uncharacterized protein. (742 aa)
	F7E7S3_ORNAN	NR LBD domain-containing protein. (341 aa)
	GAS6	Growth arrest specific 6. (593 aa)
	PDGFC	Platelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (305 aa)
	F7EVB2_ORNAN	Protein kinase domain-containing protein. (142 aa)
	F7EJR5_ORNAN	Fibronectin type-III domain-containing protein. (68 aa)
	F7EB09_ORNAN	Uncharacterized protein. (108 aa)
	F6S0E0_ORNAN	Receptor protein-tyrosine kinase. (603 aa)
	NF1	Ras-GAP domain-containing protein. (1467 aa)
	F7EYA7_ORNAN	Uncharacterized protein. (179 aa)
	K7E6F9_ORNAN	Uncharacterized protein. (156 aa)
	K7EAD1_ORNAN	DAGKc domain-containing protein. (48 aa)
	K7ED41_ORNAN	Cdc6_C domain-containing protein. (115 aa)
	PEX2	Uncharacterized protein. (128 aa)
	K7EEV6_ORNAN	WAPL domain-containing protein. (169 aa)
	K7EFP4_ORNAN	Uncharacterized protein. (71 aa)
	K7EI65_ORNAN	Fibronectin type-III domain-containing protein. (103 aa)
	WAPL	Uncharacterized protein. (400 aa)
	CDC6	AAA domain-containing protein. (372 aa)
	ENSOANP00000023661	annotation not available (113 aa)
	CAV1	Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (113 aa)
	F6TYH7_ORNAN	Poly [ADP-ribose] polymerase. (927 aa)
	AQP1	Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (188 aa)
	F6U411_ORNAN	CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (462 aa)
	FBXO4	F-box domain-containing protein. (260 aa)
	FN1	Uncharacterized protein. (1001 aa)
	CDK6	Cyclin dependent kinase 6. (203 aa)
	TP53	P53 domain-containing protein. (87 aa)
	DAB2IP	DAB2 interacting protein. (991 aa)
	F7BJI8_ORNAN	WAPL domain-containing protein. (412 aa)
	SPHK1	Uncharacterized protein. (270 aa)
	F7D6N2_ORNAN	Uncharacterized protein. (250 aa)
	DDR2	Discoidin domain receptor tyrosine kinase 2. (839 aa)
	MORC3	CW-type domain-containing protein. (913 aa)
	PML	Uncharacterized protein. (331 aa)
	SIRT6	Sirtuin 6. (269 aa)
	WNT2	Protein Wnt-2; Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters (By similarity). (361 aa)
	F6XNV8_ORNAN	Uncharacterized protein. (363 aa)
	MYC	BHLH domain-containing protein. (182 aa)
	WNT2B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (342 aa)
	LIF	LIF interleukin 6 family cytokine. (201 aa)
	EREG	Epiregulin. (163 aa)
	PDGFB	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (212 aa)
	F6UJ31_ORNAN	Uncharacterized protein. (1385 aa)
	ITGB3	Integrin beta; Belongs to the integrin beta chain family. (725 aa)
	F6PPF5_ORNAN	Uncharacterized protein. (471 aa)
	BMI1	RING-type domain-containing protein. (326 aa)
	FOSL2	FOS like 2, AP-1 transcription factor subunit. (308 aa)
	F6PVL6_ORNAN	Uncharacterized protein. (918 aa)
	IGF1	Insulin like growth factor 1. (153 aa)
	ZMIZ1	SP-RING-type domain-containing protein. (480 aa)
	B4GALT7	Beta-1,4-galactosyltransferase 7. (324 aa)
	F7DL14_ORNAN	Uncharacterized protein. (51 aa)
	PDGFRA	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (872 aa)

Your Current Organism:

Ornithorhynchus anatinus

NCBI taxonomy Id: 9258
Other names: O. anatinus, Platypus anatinus, duck-billed platypus, duckbill platypus, platypus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BMI1	MYC	ENSOANP00000009061	ENSOANP00000012891	RING-type domain-containing protein.	BHLH domain-containing protein.	0.521
BMI1	TP53	ENSOANP00000009061	ENSOANP00000018980	RING-type domain-containing protein.	P53 domain-containing protein.	0.561
CAV1	F6ZML7_ORNAN	ENSOANP00000023660	ENSOANP00000005288	Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...]	Nuclear receptor domain-containing protein.	0.585
CAV1	F7E7S3_ORNAN	ENSOANP00000023660	ENSOANP00000024511	Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...]	NR LBD domain-containing protein.	0.585
CAV1	ITGB3	ENSOANP00000023660	ENSOANP00000010366	Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...]	Integrin beta; Belongs to the integrin beta chain family.	0.916
CDC6	CDK6	ENSOANP00000024344	ENSOANP00000019199	AAA domain-containing protein.	Cyclin dependent kinase 6.	0.822
CDC6	K7ED41_ORNAN	ENSOANP00000024344	ENSOANP00000031448	AAA domain-containing protein.	Cdc6_C domain-containing protein.	0.900
CDC73	F6V4A8_ORNAN	ENSOANP00000004702	ENSOANP00000004701	CDC73_N domain-containing protein.	CDC73_C domain-containing protein.	0.929
CDK6	CDC6	ENSOANP00000019199	ENSOANP00000024344	Cyclin dependent kinase 6.	AAA domain-containing protein.	0.822
CDK6	F7EB09_ORNAN	ENSOANP00000019199	ENSOANP00000026784	Cyclin dependent kinase 6.	Uncharacterized protein.	0.511
CDK6	K7ED41_ORNAN	ENSOANP00000019199	ENSOANP00000031448	Cyclin dependent kinase 6.	Cdc6_C domain-containing protein.	0.822
CDK6	TP53	ENSOANP00000019199	ENSOANP00000018980	Cyclin dependent kinase 6.	P53 domain-containing protein.	0.796
DAB2IP	F6PVL6_ORNAN	ENSOANP00000018946	ENSOANP00000009021	DAB2 interacting protein.	Uncharacterized protein.	0.410
DAB2IP	K7EFP4_ORNAN	ENSOANP00000018946	ENSOANP00000032351	DAB2 interacting protein.	Uncharacterized protein.	0.410
DAB2IP	NF1	ENSOANP00000018946	ENSOANP00000027864	DAB2 interacting protein.	Ras-GAP domain-containing protein.	0.410
DDR2	GAS6	ENSOANP00000015964	ENSOANP00000024662	Discoidin domain receptor tyrosine kinase 2.	Growth arrest specific 6.	0.569
DDR2	WNT2	ENSOANP00000015964	ENSOANP00000013967	Discoidin domain receptor tyrosine kinase 2.	Protein Wnt-2; Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters (By similarity).	0.422
ENSOANP00000023661	F6ZML7_ORNAN	ENSOANP00000023661	ENSOANP00000005288	annotation not available	Nuclear receptor domain-containing protein.	0.585
ENSOANP00000023661	F7E7S3_ORNAN	ENSOANP00000023661	ENSOANP00000024511	annotation not available	NR LBD domain-containing protein.	0.585
EREG	PDGFRA	ENSOANP00000011021	ENSOANP00000006000	Epiregulin.	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.650