(68 nodes) Response to glucocorticoid network (Ornithorhynchus anatinus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PAM	Peptidylglycine alpha-amidating monooxygenase. (1024 aa)
	CASP9	Caspase 9; Belongs to the peptidase C14A family. (396 aa)
	SSTR5	Somatostatin receptor 5; Belongs to the G-protein coupled receptor 1 family. (361 aa)
	EIF4E	Eukaryotic translation initiation factor 4E; Belongs to the eukaryotic initiation factor 4E family. (182 aa)
	IL10	Interleukin 10. (181 aa)
	PPARGC1B	PPARG coactivator 1 beta. (893 aa)
	PCK1	Phosphoenolpyruvate carboxykinase 1. (695 aa)
	FLT3	Fms related tyrosine kinase 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1008 aa)
	GJB2	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (226 aa)
	F7EV44_ORNAN	Uncharacterized protein. (900 aa)
	GHRHR	G_PROTEIN_RECEP_F2_4 domain-containing protein. (96 aa)
	AXIN2	Axin 2. (841 aa)
	UBE2L3	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (64 aa)
	PCK2	Phosphoenolpyruvate carboxykinase 2, mitochondrial. (662 aa)
	SLIT3	Slit guidance ligand 3. (1356 aa)
	F6QSB6_ORNAN	FERM_F1 domain-containing protein. (75 aa)
	AREG	Amphiregulin. (237 aa)
	USP8	Uncharacterized protein; Belongs to the peptidase C19 family. (1122 aa)
	GOT1	Aspartate aminotransferase. (385 aa)
	SLIT2	Slit guidance ligand 2. (1332 aa)
	ACSBG1	Acyl-CoA synthetase bubblegum family member 1. (511 aa)
	NR3C1	Nuclear receptor subfamily 3 group C member 1. (779 aa)
	JAK2	Tyrosine-protein kinase. (948 aa)
	GDNF	Glial cell derived neurotrophic factor. (218 aa)
	CYP1B1	Uncharacterized protein; Belongs to the cytochrome P450 family. (195 aa)
	SSTR2	Somatostatin receptor 2; Belongs to the G-protein coupled receptor 1 family. (374 aa)
	DDIT4	DNA damage inducible transcript 4. (230 aa)
	ZFP36L2	Uncharacterized protein. (287 aa)
	RPS6KB1	Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (478 aa)
	F6Z260_ORNAN	Peptidase_M14 domain-containing protein. (379 aa)
	PAPPA	Pappalysin 1. (1604 aa)
	GSK3B	Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (247 aa)
	BCKDHB	Branched chain keto acid dehydrogenase E1 subunit beta. (338 aa)
	PCSK1	Proprotein convertase subtilisin/kexin type 1; Belongs to the peptidase S8 family. (628 aa)
	FOSL1	FOS like 1, AP-1 transcription factor subunit. (233 aa)
	F6QCM2_ORNAN	Uncharacterized protein. (188 aa)
	F6W873_ORNAN	Tyrosine-protein kinase receptor. (1150 aa)
	PDCD7	Uncharacterized protein. (231 aa)
	K7EF37_ORNAN	AGC-kinase C-terminal domain-containing protein. (95 aa)
	K7EF21_ORNAN	TGFb_propeptide domain-containing protein. (76 aa)
	K7EEP2_ORNAN	Uncharacterized protein. (93 aa)
	TAT	Aminotran_1_2 domain-containing protein. (64 aa)
	K7ED65_ORNAN	Uncharacterized protein. (112 aa)
	K7ECQ4_ORNAN	Pkinase_Tyr domain-containing protein. (71 aa)
	ENSOANP00000031210	annotation not available (90 aa)
	IGF1R	Recep_L_domain domain-containing protein. (214 aa)
	K7E974_ORNAN	3Beta_HSD domain-containing protein; Belongs to the 3-beta-HSD family. (369 aa)
	ENSOANP00000029452	annotation not available (102 aa)
	CPN1	Peptidase_M14 domain-containing protein. (109 aa)
	IL6	Uncharacterized protein. (154 aa)
	ENSOANP00000026171	annotation not available (132 aa)
	TFAP4	BHLH domain-containing protein. (235 aa)
	F7CFL6_ORNAN	MYND-type domain-containing protein. (216 aa)
	SMYD3	SET domain-containing protein. (369 aa)
	TRIM63	Tripartite motif containing 63. (367 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1069 aa)
	CLDN1	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (226 aa)
	SSTR3	Somatostatin receptor 3; Belongs to the G-protein coupled receptor 1 family. (431 aa)
	ANXA1	Annexin. (357 aa)
	OXT	Uncharacterized protein; Belongs to the vasopressin/oxytocin family. (124 aa)
	AQP1	Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (188 aa)
	FBXO32	F-box protein 32. (298 aa)
	CPS1	ATP-grasp domain-containing protein. (704 aa)
	F7FKQ1_ORNAN	Glutamine amidotransferase type-1 domain-containing protein. (520 aa)
	F7D7Q7_ORNAN	Peptidase_M14 domain-containing protein. (79 aa)
	GPR83	G protein-coupled receptor 83; Belongs to the G-protein coupled receptor 1 family. (396 aa)
	F6ZI79_ORNAN	Uncharacterized protein. (58 aa)
	HNRNPU	Heterogeneous nuclear ribonucleoprotein U. (585 aa)

Your Current Organism:

Ornithorhynchus anatinus

NCBI taxonomy Id: 9258
Other names: O. anatinus, Platypus anatinus, duck-billed platypus, duckbill platypus, platypus

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANXA1	CASP9	ENSOANP00000020763	ENSOANP00000015596	Annexin.	Caspase 9; Belongs to the peptidase C14A family.	0.502
AREG	ENSOANP00000026171	ENSOANP00000011022	ENSOANP00000026171	Amphiregulin.	annotation not available	0.410
AREG	ENSOANP00000031210	ENSOANP00000011022	ENSOANP00000031210	Amphiregulin.	annotation not available	0.410
AREG	IGF1R	ENSOANP00000011022	ENSOANP00000030177	Amphiregulin.	Recep_L_domain domain-containing protein.	0.703
AREG	PIK3CA	ENSOANP00000011022	ENSOANP00000021943	Amphiregulin.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.410
AXIN2	GSK3B	ENSOANP00000012819	ENSOANP00000002674	Axin 2.	Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily.	0.995
CASP9	ANXA1	ENSOANP00000015596	ENSOANP00000020763	Caspase 9; Belongs to the peptidase C14A family.	Annexin.	0.502
CASP9	IL6	ENSOANP00000015596	ENSOANP00000028453	Caspase 9; Belongs to the peptidase C14A family.	Uncharacterized protein.	0.555
CLDN1	IL10	ENSOANP00000021757	ENSOANP00000015289	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Interleukin 10.	0.412
CPN1	F6Z260_ORNAN	ENSOANP00000029288	ENSOANP00000003483	Peptidase_M14 domain-containing protein.	Peptidase_M14 domain-containing protein.	0.467
CPS1	F6QCM2_ORNAN	ENSOANP00000017521	ENSOANP00000001660	ATP-grasp domain-containing protein.	Uncharacterized protein.	0.723
CPS1	F6ZI79_ORNAN	ENSOANP00000017521	ENSOANP00000016477	ATP-grasp domain-containing protein.	Uncharacterized protein.	0.723
CPS1	F7FKQ1_ORNAN	ENSOANP00000017521	ENSOANP00000017520	ATP-grasp domain-containing protein.	Glutamine amidotransferase type-1 domain-containing protein.	0.922
EIF4E	K7EF37_ORNAN	ENSOANP00000015298	ENSOANP00000032144	Eukaryotic translation initiation factor 4E; Belongs to the eukaryotic initiation factor 4E family.	AGC-kinase C-terminal domain-containing protein.	0.527
EIF4E	RPS6KB1	ENSOANP00000015298	ENSOANP00000003529	Eukaryotic translation initiation factor 4E; Belongs to the eukaryotic initiation factor 4E family.	Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.	0.527
ENSOANP00000026171	AREG	ENSOANP00000026171	ENSOANP00000011022	annotation not available	Amphiregulin.	0.410
ENSOANP00000026171	ENSOANP00000031210	ENSOANP00000026171	ENSOANP00000031210	annotation not available	annotation not available	0.900
ENSOANP00000026171	FLT3	ENSOANP00000026171	ENSOANP00000014439	annotation not available	Fms related tyrosine kinase 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.491
ENSOANP00000031210	AREG	ENSOANP00000031210	ENSOANP00000011022	annotation not available	Amphiregulin.	0.410
ENSOANP00000031210	ENSOANP00000026171	ENSOANP00000031210	ENSOANP00000026171	annotation not available	annotation not available	0.900