(68 nodes) Neuron apoptotic process network (Ornithorhynchus anatinus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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co-expression

protein homology

Your Input:
	NAE1	NEDD8 activating enzyme E1 subunit 1. (445 aa)
	AARS1	Alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. Belongs to the class-II aminoacyl-tRNA synthetase family. (968 aa)
	CASP7	Uncharacterized protein; Belongs to the peptidase C14A family. (302 aa)
	F6TT88_ORNAN	Gp_dh_N domain-containing protein. (76 aa)
	F6SWC6_ORNAN	Uncharacterized protein. (274 aa)
	STXBP1	Syntaxin binding protein 1; Belongs to the STXBP/unc-18/SEC1 family. (601 aa)
	DNAJC5B	DnaJ heat shock protein family (Hsp40) member C5 beta. (196 aa)
	TRPC5	Transient receptor potential cation channel subfamily C member 5; Belongs to the transient receptor (TC 1.A.4) family. (850 aa)
	F6UC14_ORNAN	Uncharacterized protein. (374 aa)
	CIT	Uncharacterized protein. (385 aa)
	TMTC4-2	Uncharacterized protein. (54 aa)
	GAPDH	Gp_dh_C domain-containing protein. (161 aa)
	DNAJC5	DnaJ heat shock protein family (Hsp40) member C5. (198 aa)
	APAF1	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1250 aa)
	F6WEJ8_ORNAN	DUF1899 domain-containing protein. (447 aa)
	BOK	BCL2 family apoptosis regulator BOK. (213 aa)
	F6PVL6_ORNAN	Uncharacterized protein. (918 aa)
	ATN1	Uncharacterized protein. (115 aa)
	NR4A2	Nuclear receptor subfamily 4 group A member 2. (518 aa)
	DIABLO	Uncharacterized protein. (247 aa)
	ATM	FAT domain-containing protein. (1029 aa)
	PPARGC1A	PPARG coactivator 1 alpha. (795 aa)
	SPG11	Spatacsin_C domain-containing protein. (1614 aa)
	RAPSN	Receptor associated protein of the synapse. (411 aa)
	TNFRSF21	TNF receptor superfamily member 21. (699 aa)
	OXR1	Oxidation resistance 1. (683 aa)
	DLX1	Distal-less homeobox 1. (254 aa)
	ATF2	Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
	ADNP	Activity dependent neuroprotector homeobox. (1127 aa)
	HIF1A	Hypoxia inducible factor 1 subunit alpha. (782 aa)
	F6UNW1_ORNAN	Uncharacterized protein. (96 aa)
	NEFL	Neurofilament light; Belongs to the intermediate filament family. (546 aa)
	CASP9	Caspase 9; Belongs to the peptidase C14A family. (396 aa)
	TMTC4	Transmembrane O-mannosyltransferase targeting cadherins 4. (778 aa)
	TP53	P53 domain-containing protein. (87 aa)
	THRB	Uncharacterized protein. (308 aa)
	F7FGF1_ORNAN	Uncharacterized protein. (121 aa)
	F6U064_ORNAN	A4_EXTRA domain-containing protein. (425 aa)
	F6S4A9_ORNAN	J domain-containing protein. (173 aa)
	TP63	Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (677 aa)
	F6Q289_ORNAN	MPN domain-containing protein. (268 aa)
	F7CHD6_ORNAN	USP8_dimer domain-containing protein. (181 aa)
	RB1	Uncharacterized protein. (725 aa)
	F7EMW0_ORNAN	Uncharacterized protein. (86 aa)
	F7EMV6_ORNAN	TAN domain-containing protein. (316 aa)
	F7EMV0_ORNAN	TAN domain-containing protein. (121 aa)
	F7BSP3_ORNAN	Uncharacterized protein. (281 aa)
	F6XFP0_ORNAN	Uncharacterized protein. (222 aa)
	FAIM2	Uncharacterized protein; Belongs to the BI1 family. (207 aa)
	NF1	Ras-GAP domain-containing protein. (1467 aa)
	F7E0I3_ORNAN	Uncharacterized protein. (569 aa)
	F6ZKP3_ORNAN	AGC-kinase C-terminal domain-containing protein. (169 aa)
	K7E7U9_ORNAN	PI3K/PI4K domain-containing protein; Belongs to the PI3/PI4-kinase family. (77 aa)
	PIGT	Uncharacterized protein. (142 aa)
	K7E960_ORNAN	Uncharacterized protein. (152 aa)
	K7E9H2_ORNAN	Uncharacterized protein. (181 aa)
	K7E9X2_ORNAN	Uncharacterized protein. (110 aa)
	DRAXIN	Uncharacterized protein. (226 aa)
	K7EA92_ORNAN	FAT domain-containing protein. (108 aa)
	K7EAL5_ORNAN	FAT domain-containing protein. (153 aa)
	K7ECM5_ORNAN	Uncharacterized protein. (169 aa)
	K7ECV0_ORNAN	Uncharacterized protein. (83 aa)
	K7ECZ6_ORNAN	Uncharacterized protein. (113 aa)
	K7EEG7_ORNAN	Uncharacterized protein. (114 aa)
	K7EFP4_ORNAN	Uncharacterized protein. (71 aa)
	K7EHV5_ORNAN	Uncharacterized protein. (251 aa)
	POLB	DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (224 aa)
	PSEN1	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (341 aa)

Your Current Organism:

Ornithorhynchus anatinus

NCBI taxonomy Id: 9258
Other names: O. anatinus, Platypus anatinus, duck-billed platypus, duckbill platypus, platypus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AARS1	F6PVL6_ORNAN	ENSOANP00000001841	ENSOANP00000009021	Alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. Belongs to the class-II aminoacyl-tRNA synthetase family.	Uncharacterized protein.	0.495
AARS1	K7EFP4_ORNAN	ENSOANP00000001841	ENSOANP00000032351	Alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. Belongs to the class-II aminoacyl-tRNA synthetase family.	Uncharacterized protein.	0.495
AARS1	NF1	ENSOANP00000001841	ENSOANP00000027864	Alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. Belongs to the class-II aminoacyl-tRNA synthetase family.	Ras-GAP domain-containing protein.	0.495
APAF1	BOK	ENSOANP00000008896	ENSOANP00000008963	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	BCL2 family apoptosis regulator BOK.	0.704
APAF1	CASP7	ENSOANP00000008896	ENSOANP00000002509	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.841
APAF1	CASP9	ENSOANP00000008896	ENSOANP00000015596	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Caspase 9; Belongs to the peptidase C14A family.	0.993
APAF1	DIABLO	ENSOANP00000008896	ENSOANP00000009922	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Uncharacterized protein.	0.833
APAF1	F6XFP0_ORNAN	ENSOANP00000008896	ENSOANP00000025948	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Uncharacterized protein.	0.558
APAF1	TP53	ENSOANP00000008896	ENSOANP00000018980	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	P53 domain-containing protein.	0.743
APAF1	TP63	ENSOANP00000008896	ENSOANP00000021753	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes.	0.495
ATF2	PPARGC1A	ENSOANP00000013726	ENSOANP00000010663	Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family.	PPARG coactivator 1 alpha.	0.421
ATM	F7EMV0_ORNAN	ENSOANP00000009993	ENSOANP00000024948	FAT domain-containing protein.	TAN domain-containing protein.	0.901
ATM	F7EMV6_ORNAN	ENSOANP00000009993	ENSOANP00000024947	FAT domain-containing protein.	TAN domain-containing protein.	0.940
ATM	K7E960_ORNAN	ENSOANP00000009993	ENSOANP00000030067	FAT domain-containing protein.	Uncharacterized protein.	0.858
ATM	K7EHV5_ORNAN	ENSOANP00000009993	ENSOANP00000033112	FAT domain-containing protein.	Uncharacterized protein.	0.951
ATM	TP53	ENSOANP00000009993	ENSOANP00000018980	FAT domain-containing protein.	P53 domain-containing protein.	0.982
ATM	TP63	ENSOANP00000009993	ENSOANP00000021753	FAT domain-containing protein.	Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes.	0.473
ATN1	PPARGC1A	ENSOANP00000009336	ENSOANP00000010663	Uncharacterized protein.	PPARG coactivator 1 alpha.	0.543
BOK	APAF1	ENSOANP00000008963	ENSOANP00000008896	BCL2 family apoptosis regulator BOK.	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	0.704
BOK	DIABLO	ENSOANP00000008963	ENSOANP00000009922	BCL2 family apoptosis regulator BOK.	Uncharacterized protein.	0.572