(27 nodes) Regulation of histone H3-K9 methylation network (Ornithorhynchus anatinus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ATRX	ATRX chromatin remodeler. (2423 aa)
	PRDM12	PR/SET domain 12. (217 aa)
	F6YG49_ORNAN	JmjN domain-containing protein. (164 aa)
	MYB	MYB proto-oncogene, transcription factor. (758 aa)
	KDM1A	Lysine demethylase 1A. (653 aa)
	SIRT1	Uncharacterized protein. (226 aa)
	F7BUB6_ORNAN	Rif1_N domain-containing protein. (2379 aa)
	KDM4A	Uncharacterized protein. (1068 aa)
	F6TP73_ORNAN	Uncharacterized protein. (444 aa)
	EHMT1	Uncharacterized protein. (1307 aa)
	KDM3A	Lysine demethylase 3A. (1224 aa)
	MECP2	Methyl-CpG binding protein 2. (499 aa)
	JARID2	Jumonji and AT-rich interaction domain containing 2. (1225 aa)
	SMARCB1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1. (348 aa)
	DNMT1	DNA methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1090 aa)
	F6U3W6_ORNAN	PHD-type domain-containing protein. (790 aa)
	LMNA	IF rod domain-containing protein; Belongs to the intermediate filament family. (346 aa)
	DMRTC2	DMRT like family C2. (385 aa)
	SETD7	Histone-lysine N-methyltransferase SETD7; Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes. (370 aa)
	KDM4C	Uncharacterized protein. (286 aa)
	K7E8J8_ORNAN	Uncharacterized protein. (90 aa)
	K7E9F1_ORNAN	RING-type domain-containing protein. (145 aa)
	K7EC38_ORNAN	DMAP-interaction domain-containing protein. (210 aa)
	BRCA1	Uncharacterized protein. (208 aa)
	PIH1D1	PIH1 domain-containing protein. (148 aa)
	RIF1	Uncharacterized protein. (89 aa)
	KDM4B	JmjC domain-containing protein. (87 aa)

Your Current Organism:

Ornithorhynchus anatinus

NCBI taxonomy Id: 9258
Other names: O. anatinus, Platypus anatinus, duck-billed platypus, duckbill platypus, platypus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATRX	BRCA1	ENSOANP00000003785	ENSOANP00000031186	ATRX chromatin remodeler.	Uncharacterized protein.	0.408
ATRX	DNMT1	ENSOANP00000003785	ENSOANP00000019393	ATRX chromatin remodeler.	DNA methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	0.406
ATRX	K7E9F1_ORNAN	ENSOANP00000003785	ENSOANP00000030158	ATRX chromatin remodeler.	RING-type domain-containing protein.	0.408
ATRX	K7EC38_ORNAN	ENSOANP00000003785	ENSOANP00000031095	ATRX chromatin remodeler.	DMAP-interaction domain-containing protein.	0.406
ATRX	MECP2	ENSOANP00000003785	ENSOANP00000017465	ATRX chromatin remodeler.	Methyl-CpG binding protein 2.	0.745
ATRX	SETD7	ENSOANP00000003785	ENSOANP00000024061	ATRX chromatin remodeler.	Histone-lysine N-methyltransferase SETD7; Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes.	0.417
BRCA1	ATRX	ENSOANP00000031186	ENSOANP00000003785	Uncharacterized protein.	ATRX chromatin remodeler.	0.408
BRCA1	F7BUB6_ORNAN	ENSOANP00000031186	ENSOANP00000009693	Uncharacterized protein.	Rif1_N domain-containing protein.	0.421
BRCA1	RIF1	ENSOANP00000031186	ENSOANP00000032373	Uncharacterized protein.	Uncharacterized protein.	0.421
DNMT1	ATRX	ENSOANP00000019393	ENSOANP00000003785	DNA methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	ATRX chromatin remodeler.	0.406
DNMT1	EHMT1	ENSOANP00000019393	ENSOANP00000015800	DNA methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	Uncharacterized protein.	0.463
DNMT1	F6TP73_ORNAN	ENSOANP00000019393	ENSOANP00000015516	DNA methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	Uncharacterized protein.	0.699
DNMT1	JARID2	ENSOANP00000019393	ENSOANP00000018812	DNA methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	Jumonji and AT-rich interaction domain containing 2.	0.503
DNMT1	K7E8J8_ORNAN	ENSOANP00000019393	ENSOANP00000029855	DNA methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	Uncharacterized protein.	0.463
DNMT1	K7EC38_ORNAN	ENSOANP00000019393	ENSOANP00000031095	DNA methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	DMAP-interaction domain-containing protein.	0.900
DNMT1	KDM1A	ENSOANP00000019393	ENSOANP00000006331	DNA methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	Lysine demethylase 1A.	0.630
DNMT1	MECP2	ENSOANP00000019393	ENSOANP00000017465	DNA methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	Methyl-CpG binding protein 2.	0.588
DNMT1	SETD7	ENSOANP00000019393	ENSOANP00000024061	DNA methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	Histone-lysine N-methyltransferase SETD7; Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes.	0.575
DNMT1	SIRT1	ENSOANP00000019393	ENSOANP00000007323	DNA methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	Uncharacterized protein.	0.475
EHMT1	DNMT1	ENSOANP00000015800	ENSOANP00000019393	Uncharacterized protein.	DNA methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	0.463