(69 nodes) Cellular response to alcohol network (Ornithorhynchus anatinus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	F7EG10_ORNAN	BZIP domain-containing protein. (338 aa)
	PTGER4	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (293 aa)
	MAP4K1	Protein kinase domain-containing protein. (186 aa)
	ADCY7	Guanylate cyclase domain-containing protein. (322 aa)
	F6RBC8_ORNAN	Uncharacterized protein. (185 aa)
	TP53INP1	Tumor protein p53 inducible nuclear protein 1. (235 aa)
	GLRA2	Glycine receptor alpha 2; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (452 aa)
	PTGFR	Prostaglandin F receptor. (366 aa)
	CYP1B1	Uncharacterized protein; Belongs to the cytochrome P450 family. (195 aa)
	GRAMD1C	GRAM domain containing 1C. (612 aa)
	CYP7A1	Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family. (507 aa)
	LARP1	La ribonucleoprotein domain family member 1. (977 aa)
	GLRA1	Glycine receptor alpha 1; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (452 aa)
	F6W873_ORNAN	Tyrosine-protein kinase receptor. (1150 aa)
	GLRA3	Glycine receptor alpha 3; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (341 aa)
	MLC1	Modulator of VRAC current 1. (379 aa)
	F7BXU5_ORNAN	Uncharacterized protein. (222 aa)
	FDX1	Ferredoxin 1. (146 aa)
	XRN1	5'-3' exoribonuclease 1. (1598 aa)
	CTNNB1	Catenin beta 1. (781 aa)
	LRP6	LDL receptor related protein 6. (1462 aa)
	F7EGK7_ORNAN	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (158 aa)
	SPIDR	DUF4503 domain-containing protein. (557 aa)
	ADCY8	Adenylate cyclase 8; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (953 aa)
	CFTR	Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelia [...] (1487 aa)
	RAD51	Uncharacterized protein. (119 aa)
	BLM	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (769 aa)
	GPLD1	Glycosylphosphatidylinositol specific phospholipase D1. (724 aa)
	GOLPH3	Golgi phosphoprotein 3. (236 aa)
	PRKAA2	Non-specific serine/threonine protein kinase. (533 aa)
	EFNA5	Ephrin A5; Belongs to the ephrin family. (190 aa)
	SMO	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (677 aa)
	ADCY2	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1020 aa)
	OSBPL7	Oxysterol-binding protein; Belongs to the OSBP family. (386 aa)
	AKAP8	Uncharacterized protein; Belongs to the AKAP95 family. (193 aa)
	PTCH1	Uncharacterized protein. (340 aa)
	F7G0G5_ORNAN	Uncharacterized protein. (453 aa)
	F7G0G1_ORNAN	Uncharacterized protein. (276 aa)
	PTGER2	Prostaglandin E receptor 2; Belongs to the G-protein coupled receptor 1 family. (346 aa)
	SCNN1B	Sodium channel epithelial 1 beta subunit; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (645 aa)
	SCNN1G	Uncharacterized protein; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (659 aa)
	F7C3J2_ORNAN	BZIP domain-containing protein. (239 aa)
	HNF1A	HNF1 homeobox A. (450 aa)
	GRAMD1B	GRAM domain containing 1B. (702 aa)
	RECQL5	Uncharacterized protein. (413 aa)
	F7BL40_ORNAN	LRRNT domain-containing protein. (241 aa)
	F6XFP0_ORNAN	Uncharacterized protein. (222 aa)
	F7EDM1_ORNAN	Uncharacterized protein. (285 aa)
	LRP8	Uncharacterized protein. (301 aa)
	F7EI32_ORNAN	Uncharacterized protein. (142 aa)
	ADCY6	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (574 aa)
	F6RZ89_ORNAN	Guanylate cyclase domain-containing protein. (201 aa)
	F6QZH2_ORNAN	Uncharacterized protein. (182 aa)
	PRKAA1	Non-specific serine/threonine protein kinase. (575 aa)
	SPHK2	DAGKc domain-containing protein. (120 aa)
	K7E6V9_ORNAN	Uncharacterized protein. (191 aa)
	K7E7J5_ORNAN	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (120 aa)
	K7E8M8_ORNAN	RECA_2 domain-containing protein. (216 aa)
	ADCY3	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (123 aa)
	K7E9C7_ORNAN	Uncharacterized protein. (100 aa)
	K7E9F1_ORNAN	RING-type domain-containing protein. (145 aa)
	IGF1R	Recep_L_domain domain-containing protein. (214 aa)
	K7E9P3_ORNAN	Uncharacterized protein; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (87 aa)
	K7EA40_ORNAN	Uncharacterized protein. (84 aa)
	JUP	Uncharacterized protein. (158 aa)
	BRCA1	Uncharacterized protein. (208 aa)
	K7ECF2_ORNAN	Uncharacterized protein. (117 aa)
	K7EE63_ORNAN	Guanylate cyclase domain-containing protein. (91 aa)
	K7EHI5_ORNAN	SSD domain-containing protein. (56 aa)

Your Current Organism:

Ornithorhynchus anatinus

NCBI taxonomy Id: 9258
Other names: O. anatinus, Platypus anatinus, duck-billed platypus, duckbill platypus, platypus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADCY2	ADCY3	ENSOANP00000018351	ENSOANP00000029991	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.434
ADCY2	ADCY6	ENSOANP00000018351	ENSOANP00000027036	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.701
ADCY2	ADCY7	ENSOANP00000018351	ENSOANP00000000930	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Guanylate cyclase domain-containing protein.	0.427
ADCY2	ADCY8	ENSOANP00000018351	ENSOANP00000012883	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase 8; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.466
ADCY2	F6RZ89_ORNAN	ENSOANP00000018351	ENSOANP00000027373	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Guanylate cyclase domain-containing protein.	0.684
ADCY2	F7EGK7_ORNAN	ENSOANP00000018351	ENSOANP00000011297	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.692
ADCY3	ADCY2	ENSOANP00000029991	ENSOANP00000018351	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.434
ADCY3	ADCY6	ENSOANP00000029991	ENSOANP00000027036	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.941
ADCY3	ADCY7	ENSOANP00000029991	ENSOANP00000000930	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Guanylate cyclase domain-containing protein.	0.946
ADCY3	ADCY8	ENSOANP00000029991	ENSOANP00000012883	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Adenylate cyclase 8; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.957
ADCY3	F6RZ89_ORNAN	ENSOANP00000029991	ENSOANP00000027373	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Guanylate cyclase domain-containing protein.	0.416
ADCY3	F7EGK7_ORNAN	ENSOANP00000029991	ENSOANP00000011297	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.970
ADCY3	K7E7J5_ORNAN	ENSOANP00000029991	ENSOANP00000029502	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.448
ADCY6	ADCY2	ENSOANP00000027036	ENSOANP00000018351	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.701
ADCY6	ADCY3	ENSOANP00000027036	ENSOANP00000029991	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.941
ADCY6	ADCY7	ENSOANP00000027036	ENSOANP00000000930	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Guanylate cyclase domain-containing protein.	0.644
ADCY6	ADCY8	ENSOANP00000027036	ENSOANP00000012883	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Adenylate cyclase 8; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.942
ADCY6	F7EGK7_ORNAN	ENSOANP00000027036	ENSOANP00000011297	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.916
ADCY7	ADCY2	ENSOANP00000000930	ENSOANP00000018351	Guanylate cyclase domain-containing protein.	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.427
ADCY7	ADCY3	ENSOANP00000000930	ENSOANP00000029991	Guanylate cyclase domain-containing protein.	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.946