(58 nodes) Schaffer collateral - CA1 synapse network (Ornithorhynchus anatinus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PRKCI	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (362 aa)
	PLAT	Plasminogen activator, tissue type. (595 aa)
	TNR	Uncharacterized protein. (1355 aa)
	NPTN	Neuroplastin. (370 aa)
	NTNG1	Netrin G1. (580 aa)
	PTPRD	Protein tyrosine phosphatase receptor type D. (1783 aa)
	F7CYH1_ORNAN	Uncharacterized protein. (824 aa)
	GRM1	G_PROTEIN_RECEP_F3_4 domain-containing protein. (781 aa)
	APBA1	Amyloid beta precursor protein binding family A member 1. (728 aa)
	F6VEM8_ORNAN	ANF_receptor domain-containing protein. (349 aa)
	F6ZN36_ORNAN	Uncharacterized protein. (1631 aa)
	F7FJL6_ORNAN	DAGKc domain-containing protein. (571 aa)
	ITPR1	Uncharacterized protein. (1597 aa)
	P2RX3	Purinergic receptor P2X 3. (322 aa)
	DGKI	Diacylglycerol kinase. (926 aa)
	PTPRA	Protein tyrosine phosphatase receptor type A. (775 aa)
	F6QRI0_ORNAN	SEC7 domain-containing protein. (508 aa)
	ITGB1	Integrin beta; Belongs to the integrin beta chain family. (819 aa)
	CTNNB1	Catenin beta 1. (781 aa)
	CDH11	Cadherin 11; Cadherins are calcium-dependent cell adhesion proteins. (813 aa)
	STX3	Syntaxin 3; Belongs to the syntaxin family. (253 aa)
	CACNG4	Voltage-dependent calcium channel gamma-4 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (322 aa)
	ADCY8	Adenylate cyclase 8; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (953 aa)
	DCC	Uncharacterized protein. (569 aa)
	F7BSU6_ORNAN	G_PROTEIN_RECEP_F3_4 domain-containing protein. (544 aa)
	F6QH30_ORNAN	Uncharacterized protein. (247 aa)
	PPP3R1	Uncharacterized protein. (180 aa)
	GRM5	Glutamate metabotropic receptor 5. (1185 aa)
	NTNG2	Uncharacterized protein. (91 aa)
	F7CZ62_ORNAN	Uncharacterized protein. (631 aa)
	NEFL	Neurofilament light; Belongs to the intermediate filament family. (546 aa)
	PRKCZ	Protein kinase domain-containing protein. (202 aa)
	APBA2	Uncharacterized protein. (689 aa)
	CASK	Uncharacterized protein; Belongs to the MAGUK family. (777 aa)
	EFNB2	Ephrin B2; Belongs to the ephrin family. (292 aa)
	DTNBP1	Dystrobrevin binding protein 1. (354 aa)
	F7FMR1_ORNAN	Uncharacterized protein. (175 aa)
	ABR	ABR activator of RhoGEF and GTPase. (777 aa)
	CACNG2	Voltage-dependent calcium channel gamma-2 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (224 aa)
	BCR	Uncharacterized protein. (919 aa)
	ENSOANP00000021014	annotation not available (127 aa)
	F6WE73_ORNAN	Uncharacterized protein. (548 aa)
	LRFN2	Leucine rich repeat and fibronectin type III domain containing 2. (669 aa)
	CACNG3	Calcium voltage-gated channel auxiliary subunit gamma 3. (266 aa)
	PLCG1	Uncharacterized protein. (265 aa)
	K7E7D5_ORNAN	Guanylate kinase-like domain-containing protein. (122 aa)
	K7E7J5_ORNAN	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (120 aa)
	CTNND1	Uncharacterized protein. (209 aa)
	K7E837_ORNAN	Uncharacterized protein. (80 aa)
	K7E8E9_ORNAN	PDZ domain-containing protein. (148 aa)
	K7E8J4_ORNAN	Uncharacterized protein. (65 aa)
	K7EAS4_ORNAN	Uncharacterized protein. (96 aa)
	K7EBP4_ORNAN	Uncharacterized protein. (265 aa)
	K7ECF2_ORNAN	Uncharacterized protein. (117 aa)
	K7EDG8_ORNAN	Uncharacterized protein. (57 aa)
	K7EE63_ORNAN	Guanylate cyclase domain-containing protein. (91 aa)
	K7EE78_ORNAN	SH3 domain-containing protein. (155 aa)
	K7EFH3_ORNAN	C2 domain-containing protein. (97 aa)

Your Current Organism:

Ornithorhynchus anatinus

NCBI taxonomy Id: 9258
Other names: O. anatinus, Platypus anatinus, duck-billed platypus, duckbill platypus, platypus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADCY8	K7E7J5_ORNAN	ENSOANP00000012883	ENSOANP00000029502	Adenylate cyclase 8; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.428
APBA1	CASK	ENSOANP00000003321	ENSOANP00000017853	Amyloid beta precursor protein binding family A member 1.	Uncharacterized protein; Belongs to the MAGUK family.	0.989
APBA1	K7E7D5_ORNAN	ENSOANP00000003321	ENSOANP00000029442	Amyloid beta precursor protein binding family A member 1.	Guanylate kinase-like domain-containing protein.	0.989
APBA1	STX3	ENSOANP00000003321	ENSOANP00000012750	Amyloid beta precursor protein binding family A member 1.	Syntaxin 3; Belongs to the syntaxin family.	0.626
APBA2	CASK	ENSOANP00000016448	ENSOANP00000017853	Uncharacterized protein.	Uncharacterized protein; Belongs to the MAGUK family.	0.985
APBA2	K7E7D5_ORNAN	ENSOANP00000016448	ENSOANP00000029442	Uncharacterized protein.	Guanylate kinase-like domain-containing protein.	0.985
APBA2	STX3	ENSOANP00000016448	ENSOANP00000012750	Uncharacterized protein.	Syntaxin 3; Belongs to the syntaxin family.	0.584
CACNG2	CACNG4	ENSOANP00000020324	ENSOANP00000012812	Voltage-dependent calcium channel gamma-2 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.	Voltage-dependent calcium channel gamma-4 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.	0.545
CACNG4	CACNG2	ENSOANP00000012812	ENSOANP00000020324	Voltage-dependent calcium channel gamma-4 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.	Voltage-dependent calcium channel gamma-2 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.	0.545
CASK	APBA1	ENSOANP00000017853	ENSOANP00000003321	Uncharacterized protein; Belongs to the MAGUK family.	Amyloid beta precursor protein binding family A member 1.	0.989
CASK	APBA2	ENSOANP00000017853	ENSOANP00000016448	Uncharacterized protein; Belongs to the MAGUK family.	Uncharacterized protein.	0.985
CASK	K7E7D5_ORNAN	ENSOANP00000017853	ENSOANP00000029442	Uncharacterized protein; Belongs to the MAGUK family.	Guanylate kinase-like domain-containing protein.	0.683
CASK	K7E8J4_ORNAN	ENSOANP00000017853	ENSOANP00000029851	Uncharacterized protein; Belongs to the MAGUK family.	Uncharacterized protein.	0.568
CASK	K7EDG8_ORNAN	ENSOANP00000017853	ENSOANP00000031575	Uncharacterized protein; Belongs to the MAGUK family.	Uncharacterized protein.	0.568
CASK	PPP3R1	ENSOANP00000017853	ENSOANP00000013322	Uncharacterized protein; Belongs to the MAGUK family.	Uncharacterized protein.	0.611
CASK	STX3	ENSOANP00000017853	ENSOANP00000012750	Uncharacterized protein; Belongs to the MAGUK family.	Syntaxin 3; Belongs to the syntaxin family.	0.586
CDH11	CTNNB1	ENSOANP00000012288	ENSOANP00000010865	Cadherin 11; Cadherins are calcium-dependent cell adhesion proteins.	Catenin beta 1.	0.829
CDH11	CTNND1	ENSOANP00000012288	ENSOANP00000029631	Cadherin 11; Cadherins are calcium-dependent cell adhesion proteins.	Uncharacterized protein.	0.580
CDH11	F7CZ62_ORNAN	ENSOANP00000012288	ENSOANP00000014824	Cadherin 11; Cadherins are calcium-dependent cell adhesion proteins.	Uncharacterized protein.	0.580
CDH11	K7E837_ORNAN	ENSOANP00000012288	ENSOANP00000029694	Cadherin 11; Cadherins are calcium-dependent cell adhesion proteins.	Uncharacterized protein.	0.580