(29 nodes) Negative regulation of reactive oxygen species metabolic process network (Ornithorhynchus anatinus)

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Your Input:
	G6PD	Glucose-6-phosphate 1-dehydrogenase; Catalyzes the rate-limiting step of the oxidative pentose- phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. (515 aa)
	COA8	Cytochrome c oxidase assembly factor 8. (148 aa)
	HK2	Phosphotransferase; Belongs to the hexokinase family. (52 aa)
	ABCB7	ATP binding cassette subfamily B member 7. (747 aa)
	ATG5	Autophagy protein 5; Involved in autophagic vesicle formation. (239 aa)
	PARK7	Parkinsonism associated deglycase. (189 aa)
	PPARA	Peroxisome proliferator activated receptor alpha. (409 aa)
	F7E1H5_ORNAN	Phosphotransferase. (631 aa)
	SIRT5	NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species. Modulates ketogenesis through the desuccinyl [...] (310 aa)
	TFAP2A	Transcription factor AP-2 alpha. (440 aa)
	SLC30A10	Uncharacterized protein. (239 aa)
	HIF1A	Hypoxia inducible factor 1 subunit alpha. (782 aa)
	ABCD1	ABC transmembrane type-1 domain-containing protein. (258 aa)
	F6YRH5_ORNAN	Protein kinase domain-containing protein. (453 aa)
	AATF	Uncharacterized protein. (539 aa)
	PRKN	Ubiquitin-like domain-containing protein. (54 aa)
	TP53	P53 domain-containing protein. (87 aa)
	BCR	Uncharacterized protein. (919 aa)
	VDAC1	Voltage dependent anion channel 1. (269 aa)
	F6VG16_ORNAN	ABC transporter domain-containing protein. (608 aa)
	TIGAR	Uncharacterized protein. (195 aa)
	F6VR07_ORNAN	Protein kinase domain-containing protein. (259 aa)
	F6PGR7_ORNAN	ABC transporter domain-containing protein. (144 aa)
	F7CYS4_ORNAN	Phosphotransferase. (224 aa)
	F6TQI5_ORNAN	zf-RING_14 domain-containing protein. (71 aa)
	K7E9F1_ORNAN	RING-type domain-containing protein. (145 aa)
	BRCA1	Uncharacterized protein. (208 aa)
	K7EFH3_ORNAN	C2 domain-containing protein. (97 aa)
	ABCD2	Uncharacterized protein. (77 aa)

Your Current Organism:

Ornithorhynchus anatinus

NCBI taxonomy Id: 9258
Other names: O. anatinus, Platypus anatinus, duck-billed platypus, duckbill platypus, platypus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABCD1	ABCD2	ENSOANP00000016189	ENSOANP00000032508	ABC transmembrane type-1 domain-containing protein.	Uncharacterized protein.	0.900
ABCD1	F6PGR7_ORNAN	ENSOANP00000016189	ENSOANP00000025838	ABC transmembrane type-1 domain-containing protein.	ABC transporter domain-containing protein.	0.934
ABCD2	ABCD1	ENSOANP00000032508	ENSOANP00000016189	Uncharacterized protein.	ABC transmembrane type-1 domain-containing protein.	0.900
ATG5	F6TQI5_ORNAN	ENSOANP00000006175	ENSOANP00000027320	Autophagy protein 5; Involved in autophagic vesicle formation.	zf-RING_14 domain-containing protein.	0.506
ATG5	F6VR07_ORNAN	ENSOANP00000006175	ENSOANP00000025769	Autophagy protein 5; Involved in autophagic vesicle formation.	Protein kinase domain-containing protein.	0.547
ATG5	F6YRH5_ORNAN	ENSOANP00000006175	ENSOANP00000016490	Autophagy protein 5; Involved in autophagic vesicle formation.	Protein kinase domain-containing protein.	0.547
ATG5	PRKN	ENSOANP00000006175	ENSOANP00000018924	Autophagy protein 5; Involved in autophagic vesicle formation.	Ubiquitin-like domain-containing protein.	0.506
ATG5	SIRT5	ENSOANP00000006175	ENSOANP00000011114	Autophagy protein 5; Involved in autophagic vesicle formation.	NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species. Modulates ketogenesis through the desuccinyl [...]	0.538
ATG5	TP53	ENSOANP00000006175	ENSOANP00000018980	Autophagy protein 5; Involved in autophagic vesicle formation.	P53 domain-containing protein.	0.476
ATG5	VDAC1	ENSOANP00000006175	ENSOANP00000021283	Autophagy protein 5; Involved in autophagic vesicle formation.	Voltage dependent anion channel 1.	0.679
BRCA1	TP53	ENSOANP00000031186	ENSOANP00000018980	Uncharacterized protein.	P53 domain-containing protein.	0.904
F6PGR7_ORNAN	ABCD1	ENSOANP00000025838	ENSOANP00000016189	ABC transporter domain-containing protein.	ABC transmembrane type-1 domain-containing protein.	0.934
F6TQI5_ORNAN	ATG5	ENSOANP00000027320	ENSOANP00000006175	zf-RING_14 domain-containing protein.	Autophagy protein 5; Involved in autophagic vesicle formation.	0.506
F6TQI5_ORNAN	F6VR07_ORNAN	ENSOANP00000027320	ENSOANP00000025769	zf-RING_14 domain-containing protein.	Protein kinase domain-containing protein.	0.881
F6TQI5_ORNAN	F6YRH5_ORNAN	ENSOANP00000027320	ENSOANP00000016490	zf-RING_14 domain-containing protein.	Protein kinase domain-containing protein.	0.881
F6TQI5_ORNAN	PARK7	ENSOANP00000027320	ENSOANP00000006391	zf-RING_14 domain-containing protein.	Parkinsonism associated deglycase.	0.842
F6TQI5_ORNAN	VDAC1	ENSOANP00000027320	ENSOANP00000021283	zf-RING_14 domain-containing protein.	Voltage dependent anion channel 1.	0.756
F6VR07_ORNAN	ATG5	ENSOANP00000025769	ENSOANP00000006175	Protein kinase domain-containing protein.	Autophagy protein 5; Involved in autophagic vesicle formation.	0.547
F6VR07_ORNAN	F6TQI5_ORNAN	ENSOANP00000025769	ENSOANP00000027320	Protein kinase domain-containing protein.	zf-RING_14 domain-containing protein.	0.881
F6VR07_ORNAN	PARK7	ENSOANP00000025769	ENSOANP00000006391	Protein kinase domain-containing protein.	Parkinsonism associated deglycase.	0.628