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IDH1 IDH1 KIT KIT ATP10B ATP10B GNAI1 GNAI1 K7EF82_ORNAN K7EF82_ORNAN GNAT3 GNAT3 PGM2 PGM2 FAH FAH ADSS2 ADSS2 COX1 COX1 COX2 COX2 ATP13A3 ATP13A3 PKM PKM ATP11A ATP11A ILKAP ILKAP PFKL PFKL SUCLA2 SUCLA2 PDP2 PDP2 IDH2 IDH2 F6V838_ORNAN F6V838_ORNAN MAT2A MAT2A NME7 NME7 ITPA ITPA PGM3 PGM3 NT5DC2 NT5DC2 TAMM41 TAMM41 ATP8A1 ATP8A1 NT5C2 NT5C2 F7D054_ORNAN F7D054_ORNAN ATP8B1 ATP8B1 EYA4 EYA4 GNAI3 GNAI3 F6W506_ORNAN F6W506_ORNAN TGFBR1 TGFBR1 TERT TERT PAPOLA PAPOLA PPM1G PPM1G EYA1 EYA1 ATP8B4 ATP8B4 ATP2A1 ATP2A1 PGM5 PGM5 ATP11C ATP11C PDP1 PDP1 FEN1 FEN1 PPAT PPAT F7EH46_ORNAN F7EH46_ORNAN F7CX02_ORNAN F7CX02_ORNAN CLYBL CLYBL ACVR2A ACVR2A F6XLU7_ORNAN F6XLU7_ORNAN PPM1E PPM1E ATP9A ATP9A APEX1 APEX1 ATP8A2 ATP8A2 WEE2 WEE2 F6TTP6_ORNAN F6TTP6_ORNAN F7AKT4_ORNAN F7AKT4_ORNAN ATP9B ATP9B FAN1 FAN1 TGFBR2 TGFBR2 IMPA2 IMPA2 EYA3 EYA3 ATP11B ATP11B ADCY2 ADCY2 HPRT1 HPRT1 F7AS80_ORNAN F7AS80_ORNAN PPM1A PPM1A NT5DC4 NT5DC4 DCTPP1 DCTPP1 EYA2 EYA2 RIOK3 RIOK3 F6PFW2_ORNAN F6PFW2_ORNAN PPM1B PPM1B ACVR1 ACVR1 PFKP PFKP F6WVG0_ORNAN F6WVG0_ORNAN ADSS1 ADSS1 WEE1 WEE1 RBKS RBKS NT5DC3 NT5DC3 GNAT1 GNAT1 ITPK1 ITPK1 GPHN GPHN F6R210_ORNAN F6R210_ORNAN DNTT DNTT THG1L THG1L PPTC7 PPTC7 ATP2A2 ATP2A2 PHOSPHO1 PHOSPHO1 IMPA1 IMPA1 GNAO1 GNAO1
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
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a 3D structure is known or predicted
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
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IDH1Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (415 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (977 aa)
ATP10BPhospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1246 aa)
GNAI1G protein subunit alpha i1. (302 aa)
K7EF82_ORNANEyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (60 aa)
GNAT3G protein subunit alpha transducin 3. (358 aa)
PGM2Phosphoglucomutase 2; Belongs to the phosphohexose mutase family. (595 aa)
FAHFumarylacetoacetase. (154 aa)
ADSS2Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (396 aa)
COX1Cytochrome c oxidase subunit 1; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and t [...] (513 aa)
COX2Cytochrome c oxidase subunit 2; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and t [...] (230 aa)
ATP13A3Cation-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. (1249 aa)
PKMPyruvate kinase; Belongs to the pyruvate kinase family. (279 aa)
ATP11APhospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1121 aa)
ILKAPILK associated serine/threonine phosphatase. (392 aa)
PFKLATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (751 aa)
SUCLA2Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial; ATP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (464 aa)
PDP2Pyruvate dehyrogenase phosphatase catalytic subunit 2. (535 aa)
IDH2Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (458 aa)
F6V838_ORNANPhospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (707 aa)
MAT2AS-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP. (332 aa)
NME7Nucleoside diphosphate kinase 7; Belongs to the NDK family. (376 aa)
ITPAInosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions; Belongs to the HAM1 NTPase family. (209 aa)
PGM3Phosphoacetylglucosamine mutase; Catalyzes the conversion of GlcNAc-6-P into GlcNAc-1-P during the synthesis of uridine diphosphate/UDP-GlcNAc, a sugar nucleotide critical to multiple glycosylation pathways including protein N- and O- glycosylation; Belongs to the phosphohexose mutase family. (543 aa)
NT5DC25'-nucleotidase domain containing 2. (556 aa)
TAMM41Phosphatidate cytidylyltransferase, mitochondrial; Catalyzes the formation of CDP-diacylglycerol (CDP-DAG) from phosphatidic acid (PA) in the mitochondrial inner membrane. Required for the biosynthesis of the dimeric phospholipid cardiolipin, which stabilizes supercomplexes of the mitochondrial respiratory chain in the mitochondrial inner membrane. (305 aa)
ATP8A1Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (928 aa)
NT5C25'-nucleotidase, cytosolic II. (555 aa)
F7D054_ORNANS-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP. (401 aa)
ATP8B1Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1258 aa)
EYA4Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (619 aa)
GNAI3G protein subunit alpha i3. (236 aa)
F6W506_ORNANEyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (282 aa)
TGFBR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (438 aa)
TERTTelomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (1101 aa)
PAPOLAPoly(A) polymerase; Polymerase that creates the 3'-poly(A) tail of mRNA's. (694 aa)
PPM1GProtein phosphatase, Mg2+/Mn2+ dependent 1G. (410 aa)
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (109 aa)
ATP8B4Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1073 aa)
ATP2A1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (710 aa)
PGM5Phosphoglucomutase 5; Belongs to the phosphohexose mutase family. (480 aa)
ATP11CPhospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (943 aa)
PDP1Pyruvate dehyrogenase phosphatase catalytic subunit 1. (481 aa)
FEN1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (387 aa)
PPATAmidophosphoribosyltransferase; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (485 aa)
F7EH46_ORNANAlkaline phosphatase. (172 aa)
F7CX02_ORNANUncharacterized protein. (466 aa)
CLYBLCitrate lyase beta like. (338 aa)
ACVR2ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (385 aa)
F6XLU7_ORNANFolylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family. (562 aa)
PPM1EProtein phosphatase, Mg2+/Mn2+ dependent 1E. (606 aa)
ATP9APhospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1030 aa)
APEX1DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (403 aa)
ATP8A2Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (671 aa)
WEE2Protein kinase domain-containing protein. (409 aa)
F6TTP6_ORNANPhospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1118 aa)
F7AKT4_ORNANGlycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1; Glycosyltransferase that generates the core 1 O-glycan Gal- beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins; Belongs to the glycosyltransferase 31 family. Beta3-Gal-T subfamily. (289 aa)
ATP9BPhospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1042 aa)
FAN1Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. (1036 aa)
TGFBR2Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (659 aa)
IMPA2Inositol-1-monophosphatase. (235 aa)
EYA3Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (577 aa)
ATP11BPhospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1221 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1020 aa)
HPRT1Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (218 aa)
F7AS80_ORNANPhospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1049 aa)
PPM1AProtein phosphatase, Mg2+/Mn2+ dependent 1A. (382 aa)
NT5DC4Uncharacterized protein. (434 aa)
DCTPP1dCTP pyrophosphatase 1; Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong preference for dCTP and its analogs including 5-iodo-dCTP and 5-methyl-dCTP for which it may even have a higher efficiency. May protect DNA or RNA against the incorporation of these genotoxic nucleotide analogs through their catabolism. (143 aa)
EYA2Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (492 aa)
RIOK3Serine/threonine-protein kinase RIO3; Involved in regulation of type I interferon (IFN)-dependent immune response which plays a critical role in the innate immune response against DNA and RNA viruses. (489 aa)
F6PFW2_ORNANCation-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. (1139 aa)
PPM1BPPM-type phosphatase domain-containing protein. (283 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (529 aa)
PFKPATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (764 aa)
F6WVG0_ORNANGlutathione synthetase. (357 aa)
ADSS1Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (363 aa)
WEE1Wee1-like protein kinase. (491 aa)
RBKSRibokinase; Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway. (314 aa)
NT5DC35'-nucleotidase domain containing 3. (476 aa)
GNAT1G protein subunit alpha transducin 1. (348 aa)
ITPK1Inositol-tetrakisphosphate 1-kinase. (288 aa)
GPHNMolybdopterin molybdenumtransferase; Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released. (624 aa)
F6R210_ORNANPyruvate kinase; Belongs to the pyruvate kinase family. (255 aa)
DNTTDNA nucleotidylexotransferase; Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator. (515 aa)
THG1LtRNA(His) guanylyltransferase; Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage. (300 aa)
PPTC7Protein phosphatase; Belongs to the PP2C family. (232 aa)
ATP2A2Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1061 aa)
PHOSPHO1Phosphoethanolamine/phosphocholine phosphatase. (257 aa)
IMPA1Inositol-1-monophosphatase. (282 aa)
GNAO1G protein subunit alpha o1. (254 aa)
Your Current Organism:
Ornithorhynchus anatinus
NCBI taxonomy Id: 9258
Other names: O. anatinus, Platypus anatinus, duck-billed platypus, duckbill platypus, platypus
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