(89 nodes) APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 network (Ornithorhynchus anatinus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ANAPC11	Uncharacterized protein. (96 aa)
	ENSOANP00000029586	annotation not available (99 aa)
	K7E812_ORNAN	Uncharacterized protein. (117 aa)
	K7E897_ORNAN	Uncharacterized protein. (102 aa)
	K7E8I3_ORNAN	Uncharacterized protein. (99 aa)
	PSMB7	Uncharacterized protein. (57 aa)
	CDC16	TPR_REGION domain-containing protein. (313 aa)
	ANAPC1	Uncharacterized protein. (434 aa)
	K7EAH2_ORNAN	KxDL domain-containing protein. (72 aa)
	K7EAK0_ORNAN	Uncharacterized protein. (142 aa)
	K7EBT8_ORNAN	Uncharacterized protein. (92 aa)
	TM7SF3	DUF4203 domain-containing protein. (136 aa)
	K7ECR7_ORNAN	Uncharacterized protein. (127 aa)
	K7ECV0_ORNAN	Uncharacterized protein. (83 aa)
	PSMD2	RPN1_RPN2_N domain-containing protein. (145 aa)
	K7EEG3_ORNAN	Uncharacterized protein. (65 aa)
	K7EG07_ORNAN	Uncharacterized protein. (155 aa)
	K7EG35_ORNAN	Uncharacterized protein. (135 aa)
	PSMB1	Uncharacterized protein. (72 aa)
	PSMD3	Rpn3_C domain-containing protein. (96 aa)
	K7EH90_ORNAN	ANAPC8 domain-containing protein. (143 aa)
	UBE2C	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (102 aa)
	ENSOANP00000033264	annotation not available (100 aa)
	PSMD1	Proteasome 26S subunit, non-ATPase 1. (639 aa)
	PTTG1	Uncharacterized protein. (201 aa)
	F7G479_ORNAN	Nas2_N domain-containing protein. (195 aa)
	ANAPC5	Uncharacterized protein. (438 aa)
	PSMD5	Proteasome 26S subunit, non-ATPase 5. (399 aa)
	PSMB4	Proteasome subunit beta; Belongs to the peptidase T1B family. (215 aa)
	F7F7J8_ORNAN	Proteasome subunit beta. (238 aa)
	F7AQC7_ORNAN	Peptidase_M13_N domain-containing protein. (419 aa)
	PSMD6	Proteasome 26S subunit, non-ATPase 6. (389 aa)
	F7BGF6_ORNAN	Uncharacterized protein. (87 aa)
	F6ZIN1_ORNAN	AAA domain-containing protein; Belongs to the AAA ATPase family. (360 aa)
	ANAPC16	Anaphase promoting complex subunit 16. (110 aa)
	PSMA7	Proteasome subunit alpha type. (222 aa)
	F6TGR1_ORNAN	TPR_REGION domain-containing protein. (364 aa)
	PSMC4	Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family. (337 aa)
	PSMA5	Proteasome subunit alpha type. (217 aa)
	PSMC1	Proteasome 26S subunit, ATPase 1; Belongs to the AAA ATPase family. (367 aa)
	PSMB5	Proteasome subunit beta. (263 aa)
	PSMB11	Proteasome subunit beta. (254 aa)
	UBE2D1	Ubiquitin conjugating enzyme E2 D1; Belongs to the ubiquitin-conjugating enzyme family. (147 aa)
	PSME4	Proteasome activator subunit 4. (1764 aa)
	F7FN97_ORNAN	CSN8_PSD8_EIF3K domain-containing protein. (196 aa)
	ANAPC7	Anaphase promoting complex subunit 7. (531 aa)
	F7G4U0_ORNAN	Uncharacterized protein. (381 aa)
	PSMD7	MPN domain-containing protein. (325 aa)
	UBA52	Ubiquitin A-52 residue ribosomal protein fusion product 1. (128 aa)
	PSMD14	Proteasome 26S subunit, non-ATPase 14. (310 aa)
	PSMA1	Proteasome subunit alpha type. (267 aa)
	ANAPC4	Anaphase-promoting complex subunit 4; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. Belongs to the APC4 family. (810 aa)
	F7C392_ORNAN	Proteasome subunit beta. (196 aa)
	CDC27	Uncharacterized protein. (400 aa)
	F7CPP9_ORNAN	RPN1_C domain-containing protein. (553 aa)
	FZR1	WD_REPEATS_REGION domain-containing protein. (294 aa)
	PLK1	Polo like kinase 1. (479 aa)
	PSMD12	Proteasome 26S subunit, non-ATPase 12. (397 aa)
	F6QIB3_ORNAN	Uncharacterized protein. (80 aa)
	CDC20	Cell division cycle 20. (496 aa)
	PTTG1-2	annotation not available (201 aa)
	KXD1	KxDL domain-containing protein. (182 aa)
	CDC26	Cell division cycle 26. (85 aa)
	PSMA2	Proteasome subunit alpha type. (293 aa)
	PSMC6	Proteasome 26S subunit, ATPase 6; Belongs to the AAA ATPase family. (390 aa)
	RPS27A	Ribosomal protein S27a. (192 aa)
	F6TZT9_ORNAN	Uncharacterized protein. (264 aa)
	PSMA3	Proteasome subunit alpha type. (244 aa)
	AURKA	Aurora kinase A; Belongs to the protein kinase superfamily. (322 aa)
	ENSOANP00000020067	annotation not available (305 aa)
	PSMA4	Proteasome subunit alpha type. (261 aa)
	PSMB2	Proteasome subunit beta. (201 aa)
	PSMB10	Proteasome subunit beta 10. (275 aa)
	ANAPC10	Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. (185 aa)
	PSMA6	Proteasome subunit alpha type. (246 aa)
	F6VNI8_ORNAN	Uncharacterized protein. (154 aa)
	F6VNH6_ORNAN	APC1_C domain-containing protein. (371 aa)
	PSMB8	Proteasome subunit beta. (299 aa)
	PSMC2	Proteasome 26S subunit, ATPase 2; Belongs to the AAA ATPase family. (512 aa)
	RB1	Uncharacterized protein. (725 aa)
	F7FIT2_ORNAN	Uncharacterized protein. (235 aa)
	F7EL66_ORNAN	Uncharacterized protein. (169 aa)
	PSMC3	Prot_ATP_ID_OB domain-containing protein. (136 aa)
	F7ESK1_ORNAN	Uncharacterized protein. (164 aa)
	PSMD9	PDZ domain-containing protein. (174 aa)
	F6RPV1_ORNAN	Uncharacterized protein. (352 aa)
	PSME2	Proteasome activator subunit 2. (199 aa)
	F6ZFF1_ORNAN	Uncharacterized protein. (540 aa)
	PSME3	PA28_beta domain-containing protein. (104 aa)

Your Current Organism:

Ornithorhynchus anatinus

NCBI taxonomy Id: 9258
Other names: O. anatinus, Platypus anatinus, duck-billed platypus, duckbill platypus, platypus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANAPC1	ANAPC10	ENSOANP00000030467	ENSOANP00000021941	Uncharacterized protein.	Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle.	0.982
ANAPC1	ANAPC11	ENSOANP00000030467	ENSOANP00000029341	Uncharacterized protein.	Uncharacterized protein.	0.982
ANAPC1	ANAPC16	ENSOANP00000030467	ENSOANP00000004869	Uncharacterized protein.	Anaphase promoting complex subunit 16.	0.775
ANAPC1	ANAPC4	ENSOANP00000030467	ENSOANP00000010687	Uncharacterized protein.	Anaphase-promoting complex subunit 4; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. Belongs to the APC4 family.	0.972
ANAPC1	ANAPC5	ENSOANP00000030467	ENSOANP00000001245	Uncharacterized protein.	Uncharacterized protein.	0.972
ANAPC1	ANAPC7	ENSOANP00000030467	ENSOANP00000007565	Uncharacterized protein.	Anaphase promoting complex subunit 7.	0.979
ANAPC1	CDC16	ENSOANP00000030467	ENSOANP00000030411	Uncharacterized protein.	TPR_REGION domain-containing protein.	0.973
ANAPC1	CDC20	ENSOANP00000030467	ENSOANP00000013047	Uncharacterized protein.	Cell division cycle 20.	0.677
ANAPC1	CDC26	ENSOANP00000030467	ENSOANP00000015412	Uncharacterized protein.	Cell division cycle 26.	0.977
ANAPC1	CDC27	ENSOANP00000030467	ENSOANP00000011546	Uncharacterized protein.	Uncharacterized protein.	0.971
ANAPC1	ENSOANP00000020067	ENSOANP00000030467	ENSOANP00000020067	Uncharacterized protein.	annotation not available	0.463
ANAPC1	ENSOANP00000029586	ENSOANP00000030467	ENSOANP00000029586	Uncharacterized protein.	annotation not available	0.735
ANAPC1	F6RPV1_ORNAN	ENSOANP00000030467	ENSOANP00000028152	Uncharacterized protein.	Uncharacterized protein.	0.933
ANAPC1	F6TGR1_ORNAN	ENSOANP00000030467	ENSOANP00000005396	Uncharacterized protein.	TPR_REGION domain-containing protein.	0.728
ANAPC1	F6VNH6_ORNAN	ENSOANP00000030467	ENSOANP00000022247	Uncharacterized protein.	APC1_C domain-containing protein.	0.944
ANAPC1	F6VNI8_ORNAN	ENSOANP00000030467	ENSOANP00000022246	Uncharacterized protein.	Uncharacterized protein.	0.948
ANAPC1	F6ZFF1_ORNAN	ENSOANP00000030467	ENSOANP00000028817	Uncharacterized protein.	Uncharacterized protein.	0.835
ANAPC1	F7FIT2_ORNAN	ENSOANP00000030467	ENSOANP00000026083	Uncharacterized protein.	Uncharacterized protein.	0.745
ANAPC1	F7G4U0_ORNAN	ENSOANP00000030467	ENSOANP00000007953	Uncharacterized protein.	Uncharacterized protein.	0.463
ANAPC1	FZR1	ENSOANP00000030467	ENSOANP00000012196	Uncharacterized protein.	WD_REPEATS_REGION domain-containing protein.	0.944