(18 nodes) FRS-mediated FGFR3 signaling network (Ornithorhynchus anatinus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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Predicted Interactions

gene neighborhood

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Your Input:
	F6W8B0_ORNAN	Uncharacterized protein. (211 aa)
	FGF17	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (205 aa)
	CSDE1	Cold shock domain containing E1. (787 aa)
	FGFR3	Fibroblast growth factor receptor. (769 aa)
	FGF5	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (152 aa)
	F7FPT3_ORNAN	CSP domain-containing protein. (208 aa)
	FRS2	Fibroblast growth factor receptor substrate 2. (482 aa)
	PTPN11	Uncharacterized protein. (368 aa)
	FGF4	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (202 aa)
	F6PLS0_ORNAN	Uncharacterized protein. (129 aa)
	FGF9	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
	KRAS	KRAS proto-oncogene, GTPase. (188 aa)
	F7AVI5_ORNAN	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (599 aa)
	FGF18	Uncharacterized protein; Belongs to the heparin-binding growth factors family. (98 aa)
	FGF1	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
	SOS1	SOS Ras/Rac guanine nucleotide exchange factor 1. (1214 aa)
	FRS3	Fibroblast growth factor receptor substrate 3. (462 aa)
	NRAS	Uncharacterized protein. (133 aa)

Your Current Organism:

Ornithorhynchus anatinus

NCBI taxonomy Id: 9258
Other names: O. anatinus, Platypus anatinus, duck-billed platypus, duckbill platypus, platypus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CSDE1	F6PLS0_ORNAN	ENSOANP00000005313	ENSOANP00000013236	Cold shock domain containing E1.	Uncharacterized protein.	0.644
CSDE1	F6W8B0_ORNAN	ENSOANP00000005313	ENSOANP00000000252	Cold shock domain containing E1.	Uncharacterized protein.	0.437
CSDE1	F7AVI5_ORNAN	ENSOANP00000005313	ENSOANP00000018314	Cold shock domain containing E1.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.437
CSDE1	F7FPT3_ORNAN	ENSOANP00000005313	ENSOANP00000007166	Cold shock domain containing E1.	CSP domain-containing protein.	0.927
CSDE1	FGF18	ENSOANP00000005313	ENSOANP00000020199	Cold shock domain containing E1.	Uncharacterized protein; Belongs to the heparin-binding growth factors family.	0.494
CSDE1	FGF4	ENSOANP00000005313	ENSOANP00000011801	Cold shock domain containing E1.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.437
CSDE1	FGFR3	ENSOANP00000005313	ENSOANP00000005325	Cold shock domain containing E1.	Fibroblast growth factor receptor.	0.417
CSDE1	PTPN11	ENSOANP00000005313	ENSOANP00000009592	Cold shock domain containing E1.	Uncharacterized protein.	0.437
CSDE1	SOS1	ENSOANP00000005313	ENSOANP00000023572	Cold shock domain containing E1.	SOS Ras/Rac guanine nucleotide exchange factor 1.	0.711
F6PLS0_ORNAN	CSDE1	ENSOANP00000013236	ENSOANP00000005313	Uncharacterized protein.	Cold shock domain containing E1.	0.644
F6PLS0_ORNAN	F6W8B0_ORNAN	ENSOANP00000013236	ENSOANP00000000252	Uncharacterized protein.	Uncharacterized protein.	0.925
F6PLS0_ORNAN	F7AVI5_ORNAN	ENSOANP00000013236	ENSOANP00000018314	Uncharacterized protein.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.925
F6PLS0_ORNAN	F7FPT3_ORNAN	ENSOANP00000013236	ENSOANP00000007166	Uncharacterized protein.	CSP domain-containing protein.	0.644
F6PLS0_ORNAN	FGF1	ENSOANP00000013236	ENSOANP00000022448	Uncharacterized protein.	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	0.624
F6PLS0_ORNAN	FGF17	ENSOANP00000013236	ENSOANP00000002138	Uncharacterized protein.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.516
F6PLS0_ORNAN	FGF18	ENSOANP00000013236	ENSOANP00000020199	Uncharacterized protein.	Uncharacterized protein; Belongs to the heparin-binding growth factors family.	0.738
F6PLS0_ORNAN	FGF4	ENSOANP00000013236	ENSOANP00000011801	Uncharacterized protein.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.601
F6PLS0_ORNAN	FGF5	ENSOANP00000013236	ENSOANP00000005659	Uncharacterized protein.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.532
F6PLS0_ORNAN	FGF9	ENSOANP00000013236	ENSOANP00000014371	Uncharacterized protein.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.624
F6PLS0_ORNAN	FGFR3	ENSOANP00000013236	ENSOANP00000005325	Uncharacterized protein.	Fibroblast growth factor receptor.	0.634