(29 nodes) Translesion synthesis by POLK network (Ornithorhynchus anatinus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	RPS27A	Ribosomal protein S27a. (192 aa)
	ENSOANP00000020067	annotation not available (305 aa)
	RFC3	Replication factor C subunit 3. (356 aa)
	RCBTB1	RCC1 and BTB domain containing protein 1. (531 aa)
	RCBTB2	RCC1 and BTB domain containing protein 2. (527 aa)
	POLK	DNA polymerase kappa. (876 aa)
	F6XP74_ORNAN	Uncharacterized protein. (178 aa)
	MAD2L2	Mitotic arrest deficient 2 like 2. (286 aa)
	F7BRC7_ORNAN	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (214 aa)
	F6VQA8_ORNAN	ATPase_AAA_core domain-containing protein. (93 aa)
	ENSOANP00000029989	annotation not available (91 aa)
	K7EAH2_ORNAN	KxDL domain-containing protein. (72 aa)
	RFC1	Replication factor C subunit 1. (1153 aa)
	F6ZQP9_ORNAN	DUF4683 domain-containing protein. (360 aa)
	REV3L	Uncharacterized protein. (551 aa)
	KXD1	KxDL domain-containing protein. (182 aa)
	RFC2	Replication factor C subunit 2. (316 aa)
	UBA52	Ubiquitin A-52 residue ribosomal protein fusion product 1. (128 aa)
	F7CQ71_ORNAN	DNA_pol_B domain-containing protein. (151 aa)
	F7CRP1_ORNAN	DNA_pol_B domain-containing protein. (83 aa)
	ATAD5	ATPase family AAA domain containing 5. (1831 aa)
	F7G4U0_ORNAN	Uncharacterized protein. (381 aa)
	REV1	DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family. (1269 aa)
	F6S2Y0_ORNAN	Uncharacterized protein. (58 aa)
	MEIOB	Meiosis specific with OB-fold. (472 aa)
	F7EMZ8_ORNAN	DNA_pol_B_exo1 domain-containing protein. (225 aa)
	K7EFV9_ORNAN	Uncharacterized protein. (126 aa)
	RPA1	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (606 aa)
	RFC4	Replication factor C subunit 4. (228 aa)

Your Current Organism:

Ornithorhynchus anatinus

NCBI taxonomy Id: 9258
Other names: O. anatinus, Platypus anatinus, duck-billed platypus, duckbill platypus, platypus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATAD5	F6S2Y0_ORNAN	ENSOANP00000008353	ENSOANP00000006890	ATPase family AAA domain containing 5.	Uncharacterized protein.	0.470
ATAD5	F6VQA8_ORNAN	ENSOANP00000008353	ENSOANP00000025991	ATPase family AAA domain containing 5.	ATPase_AAA_core domain-containing protein.	0.835
ATAD5	F6XP74_ORNAN	ENSOANP00000008353	ENSOANP00000025138	ATPase family AAA domain containing 5.	Uncharacterized protein.	0.916
ATAD5	F6ZQP9_ORNAN	ENSOANP00000008353	ENSOANP00000015848	ATPase family AAA domain containing 5.	DUF4683 domain-containing protein.	0.470
ATAD5	F7BRC7_ORNAN	ENSOANP00000008353	ENSOANP00000025275	ATPase family AAA domain containing 5.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.900
ATAD5	F7CQ71_ORNAN	ENSOANP00000008353	ENSOANP00000008655	ATPase family AAA domain containing 5.	DNA_pol_B domain-containing protein.	0.470
ATAD5	F7CRP1_ORNAN	ENSOANP00000008353	ENSOANP00000008451	ATPase family AAA domain containing 5.	DNA_pol_B domain-containing protein.	0.470
ATAD5	F7EMZ8_ORNAN	ENSOANP00000008353	ENSOANP00000000999	ATPase family AAA domain containing 5.	DNA_pol_B_exo1 domain-containing protein.	0.470
ATAD5	MAD2L2	ENSOANP00000008353	ENSOANP00000025207	ATPase family AAA domain containing 5.	Mitotic arrest deficient 2 like 2.	0.532
ATAD5	MEIOB	ENSOANP00000008353	ENSOANP00000004638	ATPase family AAA domain containing 5.	Meiosis specific with OB-fold.	0.632
ATAD5	POLK	ENSOANP00000008353	ENSOANP00000024856	ATPase family AAA domain containing 5.	DNA polymerase kappa.	0.552
ATAD5	REV1	ENSOANP00000008353	ENSOANP00000007327	ATPase family AAA domain containing 5.	DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family.	0.564
ATAD5	REV3L	ENSOANP00000008353	ENSOANP00000015847	ATPase family AAA domain containing 5.	Uncharacterized protein.	0.470
ATAD5	RFC1	ENSOANP00000008353	ENSOANP00000016389	ATPase family AAA domain containing 5.	Replication factor C subunit 1.	0.469
ATAD5	RFC2	ENSOANP00000008353	ENSOANP00000011669	ATPase family AAA domain containing 5.	Replication factor C subunit 2.	0.911
ATAD5	RFC3	ENSOANP00000008353	ENSOANP00000024387	ATPase family AAA domain containing 5.	Replication factor C subunit 3.	0.930
ATAD5	RFC4	ENSOANP00000008353	ENSOANP00000019835	ATPase family AAA domain containing 5.	Replication factor C subunit 4.	0.835
ATAD5	RPA1	ENSOANP00000008353	ENSOANP00000017238	ATPase family AAA domain containing 5.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.632
ATAD5	RPS27A	ENSOANP00000008353	ENSOANP00000017727	ATPase family AAA domain containing 5.	Ribosomal protein S27a.	0.474
ENSOANP00000020067	F6VQA8_ORNAN	ENSOANP00000020067	ENSOANP00000025991	annotation not available	ATPase_AAA_core domain-containing protein.	0.485