(78 nodes) Signaling by Insulin receptor network (Ornithorhynchus anatinus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	F6W8B0_ORNAN	Uncharacterized protein. (211 aa)
	GRB10	Growth factor receptor bound protein 10. (596 aa)
	F7G4F7_ORNAN	V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (118 aa)
	ATP6V0A4	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (770 aa)
	FGFR2	Receptor protein-tyrosine kinase. (642 aa)
	PIK3R2	Uncharacterized protein. (724 aa)
	FGF17	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (205 aa)
	F7EVG8_ORNAN	Receptor protein-tyrosine kinase. (1063 aa)
	FGF10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (99 aa)
	PDPK1	Protein kinase domain-containing protein. (280 aa)
	ATP6V0A1	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (473 aa)
	LIM2	Lens fiber membrane intrinsic protein; Present in the thicker 16-17 nm junctions of mammalian lens fiber cells, where it may contribute to cell junctional organization. Acts as a receptor for calmodulin. May play an important role in both lens development and cataractogenesis; Belongs to the PMP-22/EMP/MP20 family. (164 aa)
	F6SMJ2_ORNAN	Uncharacterized protein. (184 aa)
	FGFR1	Fibroblast growth factor receptor. (821 aa)
	FGFR3	Fibroblast growth factor receptor. (769 aa)
	PIK3C3	Phosphatidylinositol 3-kinase catalytic subunit type 3. (811 aa)
	FGF5	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (152 aa)
	ATP6AP1	ATPase H+ transporting accessory protein 1. (418 aa)
	PIK3R1	SH2 domain-containing protein. (230 aa)
	F7E397_ORNAN	Uncharacterized protein. (407 aa)
	ATP6V1D	ATPase H+ transporting V1 subunit D. (247 aa)
	ATP6V0D2	Uncharacterized protein. (199 aa)
	F6V7W5_ORNAN	Mitogen-activated protein kinase. (345 aa)
	FRS2	Fibroblast growth factor receptor substrate 2. (482 aa)
	ATP6V0E2	Uncharacterized protein. (115 aa)
	PTPN11	Uncharacterized protein. (368 aa)
	F6Q8G6_ORNAN	PDEase domain-containing protein. (150 aa)
	PIK3R4	Phosphoinositide-3-kinase regulatory subunit 4. (1362 aa)
	F7EQ42_ORNAN	Uncharacterized protein; Belongs to the peptidase M16 family. (548 aa)
	ATP6V1H	V-type proton ATPase subunit H; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. (483 aa)
	FGF3	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (228 aa)
	FGF4	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (202 aa)
	FGF19	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (87 aa)
	F6QKY2_ORNAN	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. (735 aa)
	F6PLS0_ORNAN	Uncharacterized protein. (129 aa)
	PTPN1	Tyrosine-protein phosphatase non-receptor type. (376 aa)
	ATP6V0B	Uncharacterized protein; Belongs to the V-ATPase proteolipid subunit family. (128 aa)
	FGF9	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
	FLT3	Fms related tyrosine kinase 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1008 aa)
	FGF7	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (99 aa)
	CNST	Consortin, connexin sorting protein. (725 aa)
	ATP6V1B2	ATPase H+ transporting V1 subunit B2. (469 aa)
	ATP6V1G1	V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (99 aa)
	F7CTN6_ORNAN	Uncharacterized protein; Belongs to the heparin-binding growth factors family. (112 aa)
	ATP6V1F	V-type proton ATPase subunit F; Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (119 aa)
	F7AVI5_ORNAN	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (599 aa)
	FGF22	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (96 aa)
	FGF18	Uncharacterized protein; Belongs to the heparin-binding growth factors family. (98 aa)
	ATP6V1C1	V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (406 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1069 aa)
	GAB1	GRB2 associated binding protein 1. (648 aa)
	FGF1	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
	ATP6V1C2	V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (380 aa)
	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1034 aa)
	SOS1	SOS Ras/Rac guanine nucleotide exchange factor 1. (1214 aa)
	ATP6V1A	Uncharacterized protein. (617 aa)
	ATP6V0A2	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (765 aa)
	IDE	Insulin degrading enzyme; Belongs to the peptidase M16 family. (1021 aa)
	F6QEU7_ORNAN	TIR domain-containing protein. (558 aa)
	F6XI85_ORNAN	Uncharacterized protein. (373 aa)
	ENSOANP00000026171	annotation not available (132 aa)
	F7GDQ7_ORNAN	Spem1 domain-containing protein. (284 aa)
	FGF6	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (195 aa)
	F7EJ13_ORNAN	Uncharacterized protein. (42 aa)
	F7A752_ORNAN	ATP-synt_ab_N domain-containing protein. (135 aa)
	FLT3LG	Uncharacterized protein. (235 aa)
	K7E6U3_ORNAN	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (114 aa)
	ATP6V1B2-2	ATP-synt_ab domain-containing protein. (143 aa)
	PDE3B	PDEase domain-containing protein; Belongs to the cyclic nucleotide phosphodiesterase family. (278 aa)
	ATP6AP1L	Uncharacterized protein. (296 aa)
	K7EB94_ORNAN	PI3K/PI4K domain-containing protein; Belongs to the PI3/PI4-kinase family. (69 aa)
	MAPK1	Protein kinase domain-containing protein. (150 aa)
	ENSOANP00000031210	annotation not available (90 aa)
	K7EEC0_ORNAN	Uncharacterized protein. (173 aa)
	K7EEF9_ORNAN	Uncharacterized protein. (76 aa)
	K7EGI4_ORNAN	Protein kinase domain-containing protein. (114 aa)
	K7EH86_ORNAN	Uncharacterized protein. (75 aa)
	ATP6V1B1	Uncharacterized protein. (120 aa)

Your Current Organism:

Ornithorhynchus anatinus

NCBI taxonomy Id: 9258
Other names: O. anatinus, Platypus anatinus, duck-billed platypus, duckbill platypus, platypus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATP6AP1	ATP6V0A1	ENSOANP00000006458	ENSOANP00000004027	ATPase H+ transporting accessory protein 1.	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.	0.991
ATP6AP1	ATP6V0A2	ENSOANP00000006458	ENSOANP00000024119	ATPase H+ transporting accessory protein 1.	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.	0.980
ATP6AP1	ATP6V0A4	ENSOANP00000006458	ENSOANP00000000688	ATPase H+ transporting accessory protein 1.	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.	0.819
ATP6AP1	ATP6V0B	ENSOANP00000006458	ENSOANP00000014335	ATPase H+ transporting accessory protein 1.	Uncharacterized protein; Belongs to the V-ATPase proteolipid subunit family.	0.997
ATP6AP1	ATP6V0D2	ENSOANP00000006458	ENSOANP00000009229	ATPase H+ transporting accessory protein 1.	Uncharacterized protein.	0.996
ATP6AP1	ATP6V0E2	ENSOANP00000006458	ENSOANP00000009503	ATPase H+ transporting accessory protein 1.	Uncharacterized protein.	0.935
ATP6AP1	ATP6V1A	ENSOANP00000006458	ENSOANP00000024019	ATPase H+ transporting accessory protein 1.	Uncharacterized protein.	0.918
ATP6AP1	ATP6V1B1	ENSOANP00000006458	ENSOANP00000033215	ATPase H+ transporting accessory protein 1.	Uncharacterized protein.	0.836
ATP6AP1	ATP6V1B2	ENSOANP00000006458	ENSOANP00000016761	ATPase H+ transporting accessory protein 1.	ATPase H+ transporting V1 subunit B2.	0.836
ATP6AP1	ATP6V1B2-2	ENSOANP00000006458	ENSOANP00000029505	ATPase H+ transporting accessory protein 1.	ATP-synt_ab domain-containing protein.	0.836
ATP6AP1	ATP6V1C1	ENSOANP00000006458	ENSOANP00000020263	ATPase H+ transporting accessory protein 1.	V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	0.913
ATP6AP1	ATP6V1C2	ENSOANP00000006458	ENSOANP00000022849	ATPase H+ transporting accessory protein 1.	V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	0.888
ATP6AP1	ATP6V1D	ENSOANP00000006458	ENSOANP00000008603	ATPase H+ transporting accessory protein 1.	ATPase H+ transporting V1 subunit D.	0.948
ATP6AP1	ATP6V1F	ENSOANP00000006458	ENSOANP00000018132	ATPase H+ transporting accessory protein 1.	V-type proton ATPase subunit F; Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	0.917
ATP6AP1	ATP6V1G1	ENSOANP00000006458	ENSOANP00000016829	ATPase H+ transporting accessory protein 1.	V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	0.893
ATP6AP1	ATP6V1H	ENSOANP00000006458	ENSOANP00000011591	ATPase H+ transporting accessory protein 1.	V-type proton ATPase subunit H; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system.	0.984
ATP6AP1	CNST	ENSOANP00000006458	ENSOANP00000016256	ATPase H+ transporting accessory protein 1.	Consortin, connexin sorting protein.	0.801
ATP6AP1	F6SMJ2_ORNAN	ENSOANP00000006458	ENSOANP00000005149	ATPase H+ transporting accessory protein 1.	Uncharacterized protein.	0.961
ATP6AP1	F7A752_ORNAN	ENSOANP00000006458	ENSOANP00000028800	ATPase H+ transporting accessory protein 1.	ATP-synt_ab_N domain-containing protein.	0.836
ATP6AP1	F7EJ13_ORNAN	ENSOANP00000006458	ENSOANP00000026746	ATPase H+ transporting accessory protein 1.	Uncharacterized protein.	0.875