(11 nodes) (2010) Nuclear beta-catenin and CD44 upregulation characterize invasive cell populations in non-aggressive MCF-7 breast cancer cells. network (Ornithorhynchus anatinus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PIK3R1	SH2 domain-containing protein. (230 aa)
	CXCL12	C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family. (92 aa)
	PIK3C3	Phosphatidylinositol 3-kinase catalytic subunit type 3. (811 aa)
	EGF	Uncharacterized protein. (1007 aa)
	GAPDH	Gp_dh_C domain-containing protein. (161 aa)
	TGFB3	Transforming growth factor beta; Belongs to the TGF-beta family. (295 aa)
	F6PFX1_ORNAN	Signal transducer and activator of transcription. (755 aa)
	SOCS2	Suppressor of cytokine signaling 2. (191 aa)
	F6QE10_ORNAN	Transforming growth factor beta; Belongs to the TGF-beta family. (416 aa)
	BMP7	Bone morphogenetic protein 7. (430 aa)
	SOCS3	Suppressor of cytokine signaling 3. (201 aa)

Your Current Organism:

Ornithorhynchus anatinus

NCBI taxonomy Id: 9258
Other names: O. anatinus, Platypus anatinus, duck-billed platypus, duckbill platypus, platypus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CXCL12	EGF	ENSOANP00000001025	ENSOANP00000005820	C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family.	Uncharacterized protein.	0.504
EGF	CXCL12	ENSOANP00000005820	ENSOANP00000001025	Uncharacterized protein.	C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family.	0.504
EGF	GAPDH	ENSOANP00000005820	ENSOANP00000007123	Uncharacterized protein.	Gp_dh_C domain-containing protein.	0.441
EGF	PIK3R1	ENSOANP00000005820	ENSOANP00000007081	Uncharacterized protein.	SH2 domain-containing protein.	0.686
F6PFX1_ORNAN	SOCS2	ENSOANP00000010371	ENSOANP00000010564	Signal transducer and activator of transcription.	Suppressor of cytokine signaling 2.	0.569
F6PFX1_ORNAN	SOCS3	ENSOANP00000010371	ENSOANP00000017261	Signal transducer and activator of transcription.	Suppressor of cytokine signaling 3.	0.652
F6QE10_ORNAN	TGFB3	ENSOANP00000013619	ENSOANP00000008045	Transforming growth factor beta; Belongs to the TGF-beta family.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.697
GAPDH	EGF	ENSOANP00000007123	ENSOANP00000005820	Gp_dh_C domain-containing protein.	Uncharacterized protein.	0.441
PIK3C3	PIK3R1	ENSOANP00000005335	ENSOANP00000007081	Phosphatidylinositol 3-kinase catalytic subunit type 3.	SH2 domain-containing protein.	0.941
PIK3C3	SOCS3	ENSOANP00000005335	ENSOANP00000017261	Phosphatidylinositol 3-kinase catalytic subunit type 3.	Suppressor of cytokine signaling 3.	0.540
PIK3R1	EGF	ENSOANP00000007081	ENSOANP00000005820	SH2 domain-containing protein.	Uncharacterized protein.	0.686
PIK3R1	PIK3C3	ENSOANP00000007081	ENSOANP00000005335	SH2 domain-containing protein.	Phosphatidylinositol 3-kinase catalytic subunit type 3.	0.941
SOCS2	F6PFX1_ORNAN	ENSOANP00000010564	ENSOANP00000010371	Suppressor of cytokine signaling 2.	Signal transducer and activator of transcription.	0.569
SOCS2	SOCS3	ENSOANP00000010564	ENSOANP00000017261	Suppressor of cytokine signaling 2.	Suppressor of cytokine signaling 3.	0.546
SOCS3	F6PFX1_ORNAN	ENSOANP00000017261	ENSOANP00000010371	Suppressor of cytokine signaling 3.	Signal transducer and activator of transcription.	0.652
SOCS3	PIK3C3	ENSOANP00000017261	ENSOANP00000005335	Suppressor of cytokine signaling 3.	Phosphatidylinositol 3-kinase catalytic subunit type 3.	0.540
SOCS3	SOCS2	ENSOANP00000017261	ENSOANP00000010564	Suppressor of cytokine signaling 3.	Suppressor of cytokine signaling 2.	0.546
TGFB3	F6QE10_ORNAN	ENSOANP00000008045	ENSOANP00000013619	Transforming growth factor beta; Belongs to the TGF-beta family.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.697