(6 nodes) (2012) Novel germline PALB2 truncating mutations in African American breast cancer patients. network (Ornithorhynchus anatinus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CHEK2	Checkpoint kinase 2. (553 aa)
	MORF4L1	MRG domain-containing protein. (177 aa)
	PGR	Uncharacterized protein. (342 aa)
	BRCA2	Tower domain-containing protein. (3459 aa)
	TP53	P53 domain-containing protein. (87 aa)
	ATM	FAT domain-containing protein. (1029 aa)

Your Current Organism:

Ornithorhynchus anatinus

NCBI taxonomy Id: 9258
Other names: O. anatinus, Platypus anatinus, duck-billed platypus, duckbill platypus, platypus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATM	BRCA2	ENSOANP00000009993	ENSOANP00000024376	FAT domain-containing protein.	Tower domain-containing protein.	0.780
ATM	CHEK2	ENSOANP00000009993	ENSOANP00000014054	FAT domain-containing protein.	Checkpoint kinase 2.	0.978
ATM	TP53	ENSOANP00000009993	ENSOANP00000018980	FAT domain-containing protein.	P53 domain-containing protein.	0.982
BRCA2	ATM	ENSOANP00000024376	ENSOANP00000009993	Tower domain-containing protein.	FAT domain-containing protein.	0.780
BRCA2	CHEK2	ENSOANP00000024376	ENSOANP00000014054	Tower domain-containing protein.	Checkpoint kinase 2.	0.763
BRCA2	TP53	ENSOANP00000024376	ENSOANP00000018980	Tower domain-containing protein.	P53 domain-containing protein.	0.824
CHEK2	ATM	ENSOANP00000014054	ENSOANP00000009993	Checkpoint kinase 2.	FAT domain-containing protein.	0.978
CHEK2	BRCA2	ENSOANP00000014054	ENSOANP00000024376	Checkpoint kinase 2.	Tower domain-containing protein.	0.763
CHEK2	TP53	ENSOANP00000014054	ENSOANP00000018980	Checkpoint kinase 2.	P53 domain-containing protein.	0.996
TP53	ATM	ENSOANP00000018980	ENSOANP00000009993	P53 domain-containing protein.	FAT domain-containing protein.	0.982
TP53	BRCA2	ENSOANP00000018980	ENSOANP00000024376	P53 domain-containing protein.	Tower domain-containing protein.	0.824
TP53	CHEK2	ENSOANP00000018980	ENSOANP00000014054	P53 domain-containing protein.	Checkpoint kinase 2.	0.996