75 items (Ornithorhynchus anatinus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	RBX1	Ring-box 1. (80 aa)
	SUMO3	Small ubiquitin-related modifier. (108 aa)
	DNA2	Uncharacterized protein. (567 aa)
	MLH1	MutL homolog 1. (747 aa)
	DCLRE1C	DNA cross-link repair 1C. (700 aa)
	BRCA2	Tower domain-containing protein. (3459 aa)
	CUL4A	Cullin 4A; Belongs to the cullin family. (756 aa)
	KAT8	Chromo domain-containing protein. (104 aa)
	ERCC4	ERCC excision repair 4, endonuclease catalytic subunit. (807 aa)
	HUS1	Uncharacterized protein. (91 aa)
	NSMCE2	SP-RING-type domain-containing protein. (91 aa)
	FANCD2	Uncharacterized protein. (338 aa)
	ERCC8	Uncharacterized protein. (58 aa)
	RNF168	Uncharacterized protein. (384 aa)
	NHEJ1	Uncharacterized protein. (75 aa)
	ERCC6	Uncharacterized protein. (375 aa)
	XRCC5	Ku_N domain-containing protein. (88 aa)
	BRCA1	Uncharacterized protein. (208 aa)
	SMARCAL1	Uncharacterized protein. (139 aa)
	UIMC1	Uncharacterized protein. (216 aa)
	MUS81	Uncharacterized protein. (135 aa)
	RAD18	RING-type domain-containing protein. (232 aa)
	BARD1	Uncharacterized protein. (205 aa)
	TDP1-2	Uncharacterized protein. (59 aa)
	MDM2	MDM2 proto-oncogene. (438 aa)
	SMC5	SMC_N domain-containing protein. (1101 aa)
	DDB1	Damage specific DNA binding protein 1. (1032 aa)
	SIRT1	Uncharacterized protein. (226 aa)
	ERCC1	Uncharacterized protein. (310 aa)
	RAD23B	UBA domain-containing protein. (180 aa)
	TRIP12	Thyroid hormone receptor interactor 12. (2063 aa)
	USP11	Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (878 aa)
	TOP2A	DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1524 aa)
	YWHAE	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon; Belongs to the 14-3-3 family. (233 aa)
	DCLRE1B	DNA cross-link repair 1B. (563 aa)
	TERF2	Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (386 aa)
	CLSPN	Claspin. (1275 aa)
	RAD17	Uncharacterized protein. (680 aa)
	MSH3	DNA_MISMATCH_REPAIR_2 domain-containing protein. (1061 aa)
	DCLRE1A	DNA cross-link repair 1A. (1006 aa)
	SKP1	Skp1_POZ domain-containing protein; Belongs to the SKP1 family. (112 aa)
	CUL1	Cullin 1; Belongs to the cullin family. (776 aa)
	NR4A2	Nuclear receptor subfamily 4 group A member 2. (518 aa)
	PAXIP1	PAX interacting protein 1. (1044 aa)
	ATM	FAT domain-containing protein. (1029 aa)
	PIAS4	SP-RING-type domain-containing protein. (189 aa)
	CHEK1	Checkpoint kinase 1; Belongs to the protein kinase superfamily. (476 aa)
	XPA	XPA_C domain-containing protein. (84 aa)
	UBE2N	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (152 aa)
	TOPBP1	DNA topoisomerase II binding protein 1. (1532 aa)
	H2AX	Histone H2A; Belongs to the histone H2A family. (142 aa)
	PRKDC	FAT domain-containing protein. (3522 aa)
	BTRC	Beta-transducin repeat containing E3 ubiquitin protein ligase. (623 aa)
	PLK1	Polo like kinase 1. (479 aa)
	MAPKAPK2	MAPK activated protein kinase 2. (330 aa)
	RAD50	Zinc-hook domain-containing protein. (1209 aa)
	CHEK2	Checkpoint kinase 2. (553 aa)
	MSH2	Uncharacterized protein. (373 aa)
	RBBP8	Uncharacterized protein. (569 aa)
	RAD51	Uncharacterized protein. (119 aa)
	SLX4	Uncharacterized protein. (1178 aa)
	TIPIN	TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (290 aa)
	TOP3A	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (940 aa)
	TDP1	Tyrosyl-DNA phosphodiesterase 1. (607 aa)
	RMI1	RecQ mediated genome instability 1. (612 aa)
	UBE2T	Ubiquitin conjugating enzyme E2 T; Belongs to the ubiquitin-conjugating enzyme family. (168 aa)
	TP53BP1	BRCT domain-containing protein. (691 aa)
	XRCC6	SAP domain-containing protein. (414 aa)
	TIMELESS	Timeless circadian regulator. (1141 aa)
	TAOK1	TAO kinase 1. (1001 aa)
	UBR5	Ubiquitin protein ligase E3 component n-recognin 5. (2544 aa)
	PIAS1	Protein inhibitor of activated STAT 1. (652 aa)
	RNF8	RING-type domain-containing protein. (235 aa)
	FANCM	Uncharacterized protein. (1951 aa)
	HNRNPK	Heterogeneous nuclear ribonucleoprotein K. (464 aa)

Your Current Organism:

Ornithorhynchus anatinus

NCBI taxonomy Id: 9258
Other names: O. anatinus, Platypus anatinus, duck-billed platypus, duckbill platypus, platypus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATM	BARD1	ENSOANP00000009993	ENSOANP00000032797	FAT domain-containing protein.	Uncharacterized protein.	0.703
ATM	BRCA1	ENSOANP00000009993	ENSOANP00000031186	FAT domain-containing protein.	Uncharacterized protein.	0.984
ATM	BRCA2	ENSOANP00000009993	ENSOANP00000024376	FAT domain-containing protein.	Tower domain-containing protein.	0.780
ATM	CHEK1	ENSOANP00000009993	ENSOANP00000010076	FAT domain-containing protein.	Checkpoint kinase 1; Belongs to the protein kinase superfamily.	0.962
ATM	CHEK2	ENSOANP00000009993	ENSOANP00000014054	FAT domain-containing protein.	Checkpoint kinase 2.	0.978
ATM	DCLRE1C	ENSOANP00000009993	ENSOANP00000024215	FAT domain-containing protein.	DNA cross-link repair 1C.	0.504
ATM	DNA2	ENSOANP00000009993	ENSOANP00000023693	FAT domain-containing protein.	Uncharacterized protein.	0.522
ATM	FANCD2	ENSOANP00000009993	ENSOANP00000025994	FAT domain-containing protein.	Uncharacterized protein.	0.417
ATM	FANCM	ENSOANP00000009993	ENSOANP00000022071	FAT domain-containing protein.	Uncharacterized protein.	0.556
ATM	KAT8	ENSOANP00000009993	ENSOANP00000025480	FAT domain-containing protein.	Chromo domain-containing protein.	0.450
ATM	MDM2	ENSOANP00000009993	ENSOANP00000009459	FAT domain-containing protein.	MDM2 proto-oncogene.	0.592
ATM	MLH1	ENSOANP00000009993	ENSOANP00000024092	FAT domain-containing protein.	MutL homolog 1.	0.602
ATM	MSH2	ENSOANP00000009993	ENSOANP00000014460	FAT domain-containing protein.	Uncharacterized protein.	0.486
ATM	PAXIP1	ENSOANP00000009993	ENSOANP00000009834	FAT domain-containing protein.	PAX interacting protein 1.	0.579
ATM	PIAS4	ENSOANP00000009993	ENSOANP00000010058	FAT domain-containing protein.	SP-RING-type domain-containing protein.	0.481
ATM	PRKDC	ENSOANP00000009993	ENSOANP00000011564	FAT domain-containing protein.	FAT domain-containing protein.	0.517
ATM	RAD17	ENSOANP00000009993	ENSOANP00000002583	FAT domain-containing protein.	Uncharacterized protein.	0.467
ATM	RAD50	ENSOANP00000009993	ENSOANP00000012752	FAT domain-containing protein.	Zinc-hook domain-containing protein.	0.958
ATM	RAD51	ENSOANP00000009993	ENSOANP00000014708	FAT domain-containing protein.	Uncharacterized protein.	0.610
ATM	RBBP8	ENSOANP00000009993	ENSOANP00000014622	FAT domain-containing protein.	Uncharacterized protein.	0.505