(15 nodes) (2017) Whole-genome sequencing of spermatocytic tumors provides insights into the mutational processes operating in the male germline. network (Ornithorhynchus anatinus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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textmining

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protein homology

Your Input:
	POLR2A	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (952 aa)
	FGFR2	Receptor protein-tyrosine kinase. (642 aa)
	FGFR3	Fibroblast growth factor receptor. (769 aa)
	PRPF8	Pre-mRNA processing factor 8. (1970 aa)
	NPHS1	Ig-like domain-containing protein. (112 aa)
	PTPN11	Uncharacterized protein. (368 aa)
	XPA	XPA_C domain-containing protein. (84 aa)
	FAT1	Uncharacterized protein. (1931 aa)
	dmrt1	Doublesex and mab-3 related transcription factor 1. (93 aa)
	KRAS	KRAS proto-oncogene, GTPase. (188 aa)
	DNMT3B	DNA methyltransferase 3 beta; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (701 aa)
	dmrt1-2	Doublesex and mab-3 related transcription factor 1. (46 aa)
	MAP3K1	Mitogen-activated protein kinase kinase kinase 1. (1344 aa)
	RET	RET_CLD4 domain-containing protein. (293 aa)
	NRAS	Uncharacterized protein. (133 aa)

Your Current Organism:

Ornithorhynchus anatinus

NCBI taxonomy Id: 9258
Other names: O. anatinus, Platypus anatinus, duck-billed platypus, duckbill platypus, platypus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
FAT1	NPHS1	ENSOANP00000012453	ENSOANP00000007264	Uncharacterized protein.	Ig-like domain-containing protein.	0.503
FGFR2	FGFR3	ENSOANP00000000755	ENSOANP00000005325	Receptor protein-tyrosine kinase.	Fibroblast growth factor receptor.	0.483
FGFR2	KRAS	ENSOANP00000000755	ENSOANP00000015323	Receptor protein-tyrosine kinase.	KRAS proto-oncogene, GTPase.	0.460
FGFR2	NRAS	ENSOANP00000000755	ENSOANP00000032279	Receptor protein-tyrosine kinase.	Uncharacterized protein.	0.422
FGFR2	PTPN11	ENSOANP00000000755	ENSOANP00000009592	Receptor protein-tyrosine kinase.	Uncharacterized protein.	0.408
FGFR3	FGFR2	ENSOANP00000005325	ENSOANP00000000755	Fibroblast growth factor receptor.	Receptor protein-tyrosine kinase.	0.483
FGFR3	KRAS	ENSOANP00000005325	ENSOANP00000015323	Fibroblast growth factor receptor.	KRAS proto-oncogene, GTPase.	0.483
FGFR3	NRAS	ENSOANP00000005325	ENSOANP00000032279	Fibroblast growth factor receptor.	Uncharacterized protein.	0.541
FGFR3	PTPN11	ENSOANP00000005325	ENSOANP00000009592	Fibroblast growth factor receptor.	Uncharacterized protein.	0.472
FGFR3	RET	ENSOANP00000005325	ENSOANP00000032213	Fibroblast growth factor receptor.	RET_CLD4 domain-containing protein.	0.560
KRAS	FGFR2	ENSOANP00000015323	ENSOANP00000000755	KRAS proto-oncogene, GTPase.	Receptor protein-tyrosine kinase.	0.460
KRAS	FGFR3	ENSOANP00000015323	ENSOANP00000005325	KRAS proto-oncogene, GTPase.	Fibroblast growth factor receptor.	0.483
KRAS	PTPN11	ENSOANP00000015323	ENSOANP00000009592	KRAS proto-oncogene, GTPase.	Uncharacterized protein.	0.563
KRAS	RET	ENSOANP00000015323	ENSOANP00000032213	KRAS proto-oncogene, GTPase.	RET_CLD4 domain-containing protein.	0.525
NPHS1	FAT1	ENSOANP00000007264	ENSOANP00000012453	Ig-like domain-containing protein.	Uncharacterized protein.	0.503
NRAS	FGFR2	ENSOANP00000032279	ENSOANP00000000755	Uncharacterized protein.	Receptor protein-tyrosine kinase.	0.422
NRAS	FGFR3	ENSOANP00000032279	ENSOANP00000005325	Uncharacterized protein.	Fibroblast growth factor receptor.	0.541
NRAS	PTPN11	ENSOANP00000032279	ENSOANP00000009592	Uncharacterized protein.	Uncharacterized protein.	0.567
NRAS	RET	ENSOANP00000032279	ENSOANP00000032213	Uncharacterized protein.	RET_CLD4 domain-containing protein.	0.462
POLR2A	PRPF8	ENSOANP00000005236	ENSOANP00000006752	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	Pre-mRNA processing factor 8.	0.480