(12 nodes) (2019) Intraventricular meningiomas frequently harbor NF2 mutations but lack common genetic alterations in TRAF7, AKT1, SMO, KLF4, PIK3CA, and TERT. network (Ornithorhynchus anatinus)

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second shell of interactors

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Known Interactions

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Predicted Interactions

gene neighborhood

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Your Input:
	GSE1	Gse1 coiled-coil protein. (1225 aa)
	GSK3B	Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (247 aa)
	GABRA6	Gamma-aminobutyric acid type A receptor alpha6 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (451 aa)
	KDR	Kinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1361 aa)
	NTRK2	Ig-like domain-containing protein. (415 aa)
	SMARCB1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1. (348 aa)
	PTCH1	Uncharacterized protein. (340 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1069 aa)
	TERT	Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (1101 aa)
	SMARCA4	Uncharacterized protein. (545 aa)
	BRCA1	Uncharacterized protein. (208 aa)
	TRAF7	Uncharacterized protein. (87 aa)

Your Current Organism:

Ornithorhynchus anatinus

NCBI taxonomy Id: 9258
Other names: O. anatinus, Platypus anatinus, duck-billed platypus, duckbill platypus, platypus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BRCA1	PIK3CA	ENSOANP00000031186	ENSOANP00000021943	Uncharacterized protein.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.422
GABRA6	GSE1	ENSOANP00000005727	ENSOANP00000017995	Gamma-aminobutyric acid type A receptor alpha6 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family.	Gse1 coiled-coil protein.	0.514
GABRA6	TRAF7	ENSOANP00000005727	ENSOANP00000032494	Gamma-aminobutyric acid type A receptor alpha6 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family.	Uncharacterized protein.	0.441
GSE1	GABRA6	ENSOANP00000017995	ENSOANP00000005727	Gse1 coiled-coil protein.	Gamma-aminobutyric acid type A receptor alpha6 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family.	0.514
GSE1	GSK3B	ENSOANP00000017995	ENSOANP00000002674	Gse1 coiled-coil protein.	Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily.	0.442
GSE1	SMARCB1	ENSOANP00000017995	ENSOANP00000019292	Gse1 coiled-coil protein.	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1.	0.403
GSE1	TRAF7	ENSOANP00000017995	ENSOANP00000032494	Gse1 coiled-coil protein.	Uncharacterized protein.	0.509
GSK3B	GSE1	ENSOANP00000002674	ENSOANP00000017995	Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily.	Gse1 coiled-coil protein.	0.442
GSK3B	PTCH1	ENSOANP00000002674	ENSOANP00000021071	Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.433
GSK3B	TERT	ENSOANP00000002674	ENSOANP00000022773	Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily.	Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...]	0.408
GSK3B	TRAF7	ENSOANP00000002674	ENSOANP00000032494	Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.709
KDR	PIK3CA	ENSOANP00000006030	ENSOANP00000021943	Kinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.940
KDR	TERT	ENSOANP00000006030	ENSOANP00000022773	Kinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...]	0.426
PIK3CA	BRCA1	ENSOANP00000021943	ENSOANP00000031186	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	Uncharacterized protein.	0.422
PIK3CA	KDR	ENSOANP00000021943	ENSOANP00000006030	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	Kinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.940
PIK3CA	TRAF7	ENSOANP00000021943	ENSOANP00000032494	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	Uncharacterized protein.	0.466
PTCH1	GSK3B	ENSOANP00000021071	ENSOANP00000002674	Uncharacterized protein.	Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily.	0.433
SMARCA4	SMARCB1	ENSOANP00000024058	ENSOANP00000019292	Uncharacterized protein.	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1.	0.985
SMARCA4	TERT	ENSOANP00000024058	ENSOANP00000022773	Uncharacterized protein.	Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...]	0.678
SMARCB1	GSE1	ENSOANP00000019292	ENSOANP00000017995	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1.	Gse1 coiled-coil protein.	0.403