STRINGSTRING
SOX9 SOX9 FGF17 FGF17 FGF10 FGF10 FGF5 FGF5 FGF3 FGF3 FGF4 FGF4 FGF19 FGF19 RUNX2 RUNX2 FGF9 FGF9 FGF7 FGF7 FGF13 FGF13 FGF22 FGF22 FGF1 FGF1 FGF6 FGF6 FGF14 FGF14
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SOX9HMG box domain-containing protein. (508 aa)
FGF17Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (205 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (99 aa)
FGF5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (152 aa)
FGF3Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (228 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (202 aa)
FGF19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (87 aa)
RUNX2Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (380 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (99 aa)
FGF13Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (245 aa)
FGF22Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (96 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (195 aa)
FGF14Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (169 aa)
Your Current Organism:
Ornithorhynchus anatinus
NCBI taxonomy Id: 9258
Other names: O. anatinus, Platypus anatinus, duck-billed platypus, duckbill platypus, platypus
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