(45 nodes) Tyrosine kinase, catalytic domain network (Ornithorhynchus anatinus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	FGFR1	Fibroblast growth factor receptor. (821 aa)
	F6ZPJ2_ORNAN	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1147 aa)
	BMX	Tyrosine-protein kinase. (672 aa)
	ABL1	Tyrosine-protein kinase. (1130 aa)
	ABL2	Tyrosine-protein kinase. (1132 aa)
	EPHA3	EPH receptor A3. (1016 aa)
	F6W873_ORNAN	Tyrosine-protein kinase receptor. (1150 aa)
	F7DA92_ORNAN	Tyrosine-protein kinase receptor. (333 aa)
	FYN	Tyrosine-protein kinase. (455 aa)
	FER	Tyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (821 aa)
	EPHA4	EPH receptor A4. (986 aa)
	EGFR	Receptor protein-tyrosine kinase. (1215 aa)
	FGR	Tyrosine-protein kinase. (530 aa)
	DDR2	Discoidin domain receptor tyrosine kinase 2. (839 aa)
	FLT1	Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1317 aa)
	FLT3	Fms related tyrosine kinase 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1008 aa)
	EPHA7	EPH receptor A7. (995 aa)
	ROR1	Receptor tyrosine kinase like orphan receptor 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (884 aa)
	F6PMZ1_ORNAN	Uncharacterized protein. (1052 aa)
	EPHA6	EPH receptor A6. (833 aa)
	F6QKY2_ORNAN	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. (735 aa)
	PTK2B	Protein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (749 aa)
	PTK2	Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1142 aa)
	ERBB4	Receptor protein-tyrosine kinase. (1220 aa)
	MUSK	Muscle associated receptor tyrosine kinase. (895 aa)
	TEC	Tyrosine-protein kinase. (585 aa)
	LYN	Tyrosine-protein kinase. (514 aa)
	YES1	Tyrosine-protein kinase. (464 aa)
	ITK	Tyrosine-protein kinase. (627 aa)
	SRMS	Tyrosine-protein kinase. (510 aa)
	F7FU24_ORNAN	Tyrosine-protein kinase receptor. (2168 aa)
	PTK6	Tyrosine-protein kinase. (453 aa)
	RYK	Protein kinase domain-containing protein. (231 aa)
	TYRO3	Protein kinase domain-containing protein. (268 aa)
	BTK	Tyrosine-protein kinase. (657 aa)
	EPHA5	Uncharacterized protein. (983 aa)
	KIT	Mast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (977 aa)
	KDR	Kinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1361 aa)
	EPHB3	EPH receptor B3. (989 aa)
	FGFR3	Fibroblast growth factor receptor. (769 aa)
	F7FU08_ORNAN	Protein kinase domain-containing protein. (475 aa)
	ALK	Tyrosine-protein kinase receptor. (1256 aa)
	EPHB4	EPH receptor B4. (895 aa)
	EPHA2	EPH receptor A2. (973 aa)
	MET	Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] (982 aa)

Your Current Organism:

Ornithorhynchus anatinus

NCBI taxonomy Id: 9258
Other names: O. anatinus, Platypus anatinus, duck-billed platypus, duckbill platypus, platypus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABL1	ABL2	ENSOANP00000001666	ENSOANP00000001512	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.902
ABL1	EPHA2	ENSOANP00000001666	ENSOANP00000023610	Tyrosine-protein kinase.	EPH receptor A2.	0.913
ABL1	EPHA3	ENSOANP00000001666	ENSOANP00000000775	Tyrosine-protein kinase.	EPH receptor A3.	0.908
ABL1	EPHA4	ENSOANP00000001666	ENSOANP00000017368	Tyrosine-protein kinase.	EPH receptor A4.	0.908
ABL1	EPHA5	ENSOANP00000001666	ENSOANP00000006279	Tyrosine-protein kinase.	Uncharacterized protein.	0.908
ABL1	EPHA7	ENSOANP00000001666	ENSOANP00000014218	Tyrosine-protein kinase.	EPH receptor A7.	0.908
ABL1	EPHB3	ENSOANP00000001666	ENSOANP00000005865	Tyrosine-protein kinase.	EPH receptor B3.	0.912
ABL1	EPHB4	ENSOANP00000001666	ENSOANP00000022947	Tyrosine-protein kinase.	EPH receptor B4.	0.917
ABL2	ABL1	ENSOANP00000001512	ENSOANP00000001666	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.902
ABL2	EGFR	ENSOANP00000001512	ENSOANP00000016946	Tyrosine-protein kinase.	Receptor protein-tyrosine kinase.	0.436
ALK	EGFR	ENSOANP00000022813	ENSOANP00000016946	Tyrosine-protein kinase receptor.	Receptor protein-tyrosine kinase.	0.450
BMX	ITK	ENSOANP00000004099	ENSOANP00000008068	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.428
BMX	LYN	ENSOANP00000004099	ENSOANP00000008740	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.657
BMX	MET	ENSOANP00000004099	ENSOANP00000023659	Tyrosine-protein kinase.	Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]	0.477
BMX	PTK2	ENSOANP00000004099	ENSOANP00000011339	Tyrosine-protein kinase.	Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.434
BTK	ITK	ENSOANP00000006710	ENSOANP00000008068	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.458
BTK	KIT	ENSOANP00000006710	ENSOANP00000006034	Tyrosine-protein kinase.	Mast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.404
BTK	LYN	ENSOANP00000006710	ENSOANP00000008740	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.982
BTK	MET	ENSOANP00000006710	ENSOANP00000023659	Tyrosine-protein kinase.	Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]	0.477
BTK	TEC	ENSOANP00000006710	ENSOANP00000009333	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.944