(75 nodes) HIF-1 signaling pathway network (Ornithorhynchus anatinus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PIK3R2	Uncharacterized protein. (724 aa)
	HK2	Phosphotransferase; Belongs to the hexokinase family. (52 aa)
	INSR	Recep_L_domain domain-containing protein. (180 aa)
	RPS6KB1	Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (478 aa)
	CAMK2A	Calcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily. (492 aa)
	PGK1	Phosphoglycerate kinase. (398 aa)
	NPPA	Natriuretic peptide A. (150 aa)
	RPS6	Ribosomal protein S6. (187 aa)
	ENO2	Enolase 2. (379 aa)
	VEGFA	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (215 aa)
	PDHA1	Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (391 aa)
	PIK3R1	SH2 domain-containing protein. (230 aa)
	GAPDH	Gp_dh_C domain-containing protein. (161 aa)
	RELA	RHD domain-containing protein. (159 aa)
	TIMP1	NTR domain-containing protein. (178 aa)
	IFNGR1	Uncharacterized protein. (460 aa)
	ANGPT2	Angiopoietin 2. (495 aa)
	IGF1	Insulin like growth factor 1. (153 aa)
	NOS2	Nitric oxide synthase; Produces nitric oxide (NO). (1144 aa)
	PIK3R3	Uncharacterized protein. (462 aa)
	IFNG	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (167 aa)
	CUL2	Cullin 2; Belongs to the cullin family. (781 aa)
	PFKP	ATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (764 aa)
	ELOC	Skp1_POZ domain-containing protein. (51 aa)
	CYBB	Cytochrome b-245 beta chain. (571 aa)
	EDN1	Endothelin 1. (204 aa)
	EIF4EBP1	Uncharacterized protein. (68 aa)
	PRKCA	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (597 aa)
	ALDOA	Fructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family. (444 aa)
	LDHA	Ldh_1_C domain-containing protein. (151 aa)
	F7BRJ4_ORNAN	L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (385 aa)
	PDK1	Protein-serine/threonine kinase. (360 aa)
	HK1	Hexokinase 1. (919 aa)
	FLT1	Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1317 aa)
	HIF1A	Hypoxia inducible factor 1 subunit alpha. (782 aa)
	PRKCG	Uncharacterized protein. (304 aa)
	MAP2K2	Protein kinase domain-containing protein. (252 aa)
	EIF4E	Eukaryotic translation initiation factor 4E; Belongs to the eukaryotic initiation factor 4E family. (182 aa)
	SLC2A1	Solute carrier family 2 member 1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (483 aa)
	ALDOB	Fructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family. (364 aa)
	AKT3	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (477 aa)
	EGFR	Receptor protein-tyrosine kinase. (1215 aa)
	HMOX1	Heme oxygenase 1. (290 aa)
	EIF4E1B	Uncharacterized protein; Belongs to the eukaryotic initiation factor 4E family. (219 aa)
	F7A0Z1_ORNAN	Uncharacterized protein; Belongs to the glycosyltransferase 29 family. (311 aa)
	TLR4	Toll like receptor 4; Belongs to the Toll-like receptor family. (813 aa)
	ELOB	Elongin B. (119 aa)
	ENO1	Enolase 1. (437 aa)
	EGLN1	Uncharacterized protein. (301 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1069 aa)
	EGLN3	Egl-9 family hypoxia inducible factor 3. (239 aa)
	ALDOC	Fructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family. (368 aa)
	RBX1	Ring-box 1. (80 aa)
	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1034 aa)
	HKDC1	Phosphotransferase. (396 aa)
	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3. (500 aa)
	PFKL	ATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (751 aa)
	EGLN2	Fe2OG dioxygenase domain-containing protein. (175 aa)
	PLCG1	Uncharacterized protein. (265 aa)
	MTOR	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2191 aa)
	EP300	E1A binding protein p300. (2421 aa)
	NFKB1	RHD domain-containing protein. (267 aa)
	PDHB	Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (86 aa)
	IL6	Uncharacterized protein. (154 aa)
	TFRC	Uncharacterized protein. (205 aa)
	RPS6KB2	Protein kinase domain-containing protein. (140 aa)
	PLCG2	SH2 domain-containing protein. (238 aa)
	STAT3	STAT_alpha domain-containing protein. (156 aa)
	IGF1R	Recep_L_domain domain-containing protein. (214 aa)
	EIF4E2	Uncharacterized protein. (118 aa)
	SERPINE1	SERPIN domain-containing protein; Belongs to the serpin family. (190 aa)
	MAPK1	Protein kinase domain-containing protein. (150 aa)
	LDHB	Uncharacterized protein. (71 aa)
	MKNK1	Protein kinase domain-containing protein. (106 aa)
	AKT1	Uncharacterized protein. (230 aa)

Your Current Organism:

Ornithorhynchus anatinus

NCBI taxonomy Id: 9258
Other names: O. anatinus, Platypus anatinus, duck-billed platypus, duckbill platypus, platypus

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKT1	AKT3	ENSOANP00000033007	ENSOANP00000016278	Uncharacterized protein.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.900
AKT1	EGFR	ENSOANP00000033007	ENSOANP00000016946	Uncharacterized protein.	Receptor protein-tyrosine kinase.	0.495
AKT1	MAPK1	ENSOANP00000033007	ENSOANP00000030955	Uncharacterized protein.	Protein kinase domain-containing protein.	0.927
AKT1	MTOR	ENSOANP00000033007	ENSOANP00000027148	Uncharacterized protein.	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.	0.955
AKT1	NOS2	ENSOANP00000033007	ENSOANP00000009010	Uncharacterized protein.	Nitric oxide synthase; Produces nitric oxide (NO).	0.934
AKT1	PIK3CA	ENSOANP00000033007	ENSOANP00000021943	Uncharacterized protein.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.963
AKT1	PIK3CB	ENSOANP00000033007	ENSOANP00000023160	Uncharacterized protein.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.949
AKT1	PIK3R1	ENSOANP00000033007	ENSOANP00000007081	Uncharacterized protein.	SH2 domain-containing protein.	0.955
AKT1	PIK3R2	ENSOANP00000033007	ENSOANP00000002083	Uncharacterized protein.	Uncharacterized protein.	0.942
AKT1	PIK3R3	ENSOANP00000033007	ENSOANP00000009424	Uncharacterized protein.	Uncharacterized protein.	0.949
AKT1	RELA	ENSOANP00000033007	ENSOANP00000007630	Uncharacterized protein.	RHD domain-containing protein.	0.465
AKT1	RPS6KB1	ENSOANP00000033007	ENSOANP00000003529	Uncharacterized protein.	Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.	0.950
AKT1	RPS6KB2	ENSOANP00000033007	ENSOANP00000029618	Uncharacterized protein.	Protein kinase domain-containing protein.	0.950
AKT3	AKT1	ENSOANP00000016278	ENSOANP00000033007	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.900
AKT3	MAPK1	ENSOANP00000016278	ENSOANP00000030955	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Protein kinase domain-containing protein.	0.927
AKT3	MTOR	ENSOANP00000016278	ENSOANP00000027148	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.	0.955
AKT3	NOS2	ENSOANP00000016278	ENSOANP00000009010	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Nitric oxide synthase; Produces nitric oxide (NO).	0.934
AKT3	PIK3CA	ENSOANP00000016278	ENSOANP00000021943	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.946
AKT3	PIK3CB	ENSOANP00000016278	ENSOANP00000023160	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.949
AKT3	PIK3R1	ENSOANP00000016278	ENSOANP00000007081	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	SH2 domain-containing protein.	0.945