43 items (Ornithorhynchus anatinus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CASP3	Caspase 3; Belongs to the peptidase C14A family. (285 aa)
	SESN2	Uncharacterized protein. (427 aa)
	COP1	COP1 E3 ubiquitin ligase. (596 aa)
	RRM2B	Ribonucleotide reductase regulatory TP53 inducible subunit M2B. (297 aa)
	CCNE2	Cyclin E2; Belongs to the cyclin family. (405 aa)
	F6STU0_ORNAN	ANK_REP_REGION domain-containing protein. (106 aa)
	CD82	Tetraspanin. (263 aa)
	CCNG1	Cyclin G1; Belongs to the cyclin family. (295 aa)
	F7A3C5_ORNAN	Uncharacterized protein; Belongs to the peptidase C14A family. (487 aa)
	SHISA5	Shisa family member 5. (233 aa)
	CDK1	Cyclin dependent kinase 1; Belongs to the protein kinase superfamily. (303 aa)
	IGFBP3	Thyroglobulin type-1 domain-containing protein. (182 aa)
	RRM2	Ribonucleotide reductase regulatory subunit M2. (399 aa)
	IGF1	Insulin like growth factor 1. (153 aa)
	APAF1	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1250 aa)
	MDM2	MDM2 proto-oncogene. (438 aa)
	SFN	Stratifin; Belongs to the 14-3-3 family. (255 aa)
	ATM	FAT domain-containing protein. (1029 aa)
	DDB2	Damage specific DNA binding protein 2. (346 aa)
	CHEK1	Checkpoint kinase 1; Belongs to the protein kinase superfamily. (476 aa)
	RCHY1	Ring finger and CHY zinc finger domain containing 1. (229 aa)
	SERPINB5	Serpin family B member 5; Belongs to the serpin family. (375 aa)
	TP53I3	Tumor protein p53 inducible protein 3. (341 aa)
	GADD45A	Ribosomal_L7Ae domain-containing protein. (321 aa)
	CHEK2	Checkpoint kinase 2. (553 aa)
	LOC100077443	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
	CCNG2	Cyclin G2; Belongs to the cyclin family. (362 aa)
	ZMAT3	Zinc finger matrin-type 3. (262 aa)
	TSC2	Uncharacterized protein. (625 aa)
	CCNB1	Cyclin B1; Belongs to the cyclin family. (415 aa)
	BID	Uncharacterized protein. (138 aa)
	PPM1D	Protein phosphatase, Mg2+/Mn2+ dependent 1D. (468 aa)
	TP53	P53 domain-containing protein. (87 aa)
	CDK6	Cyclin dependent kinase 6. (203 aa)
	CCNB2	Cyclin B2; Belongs to the cyclin family. (405 aa)
	ATR	Uncharacterized protein. (473 aa)
	MDM4	Protein Mdm4; Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Belongs to the MDM2/MDM4 family. (464 aa)
	CCND2	Uncharacterized protein; Belongs to the cyclin family. (227 aa)
	PERP	P53 apoptosis effector related to PMP22. (125 aa)
	SESN1	Sestrin 1. (465 aa)
	CCND3	Cyclin_C domain-containing protein. (170 aa)
	SERPINE1	SERPIN domain-containing protein; Belongs to the serpin family. (190 aa)
	FAS	Death domain-containing protein. (114 aa)

Your Current Organism:

Ornithorhynchus anatinus

NCBI taxonomy Id: 9258
Other names: O. anatinus, Platypus anatinus, duck-billed platypus, duckbill platypus, platypus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APAF1	CASP3	ENSOANP00000008896	ENSOANP00000000517	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Caspase 3; Belongs to the peptidase C14A family.	0.987
APAF1	DDB2	ENSOANP00000008896	ENSOANP00000009996	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Damage specific DNA binding protein 2.	0.404
APAF1	F7A3C5_ORNAN	ENSOANP00000008896	ENSOANP00000006352	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.761
APAF1	LOC100077443	ENSOANP00000008896	ENSOANP00000014572	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.999
APAF1	TP53	ENSOANP00000008896	ENSOANP00000018980	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	P53 domain-containing protein.	0.743
ATM	ATR	ENSOANP00000009993	ENSOANP00000020304	FAT domain-containing protein.	Uncharacterized protein.	0.947
ATM	CDK1	ENSOANP00000009993	ENSOANP00000006989	FAT domain-containing protein.	Cyclin dependent kinase 1; Belongs to the protein kinase superfamily.	0.409
ATM	CHEK1	ENSOANP00000009993	ENSOANP00000010076	FAT domain-containing protein.	Checkpoint kinase 1; Belongs to the protein kinase superfamily.	0.962
ATM	CHEK2	ENSOANP00000009993	ENSOANP00000014054	FAT domain-containing protein.	Checkpoint kinase 2.	0.978
ATM	COP1	ENSOANP00000009993	ENSOANP00000001475	FAT domain-containing protein.	COP1 E3 ubiquitin ligase.	0.406
ATM	F7A3C5_ORNAN	ENSOANP00000009993	ENSOANP00000006352	FAT domain-containing protein.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.907
ATM	MDM2	ENSOANP00000009993	ENSOANP00000009459	FAT domain-containing protein.	MDM2 proto-oncogene.	0.592
ATM	MDM4	ENSOANP00000009993	ENSOANP00000021247	FAT domain-containing protein.	Protein Mdm4; Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Belongs to the MDM2/MDM4 family.	0.524
ATM	TP53	ENSOANP00000009993	ENSOANP00000018980	FAT domain-containing protein.	P53 domain-containing protein.	0.982
ATR	ATM	ENSOANP00000020304	ENSOANP00000009993	Uncharacterized protein.	FAT domain-containing protein.	0.947
ATR	CDK1	ENSOANP00000020304	ENSOANP00000006989	Uncharacterized protein.	Cyclin dependent kinase 1; Belongs to the protein kinase superfamily.	0.538
ATR	CDK6	ENSOANP00000020304	ENSOANP00000019199	Uncharacterized protein.	Cyclin dependent kinase 6.	0.538
ATR	CHEK1	ENSOANP00000020304	ENSOANP00000010076	Uncharacterized protein.	Checkpoint kinase 1; Belongs to the protein kinase superfamily.	0.977
ATR	CHEK2	ENSOANP00000020304	ENSOANP00000014054	Uncharacterized protein.	Checkpoint kinase 2.	0.963
ATR	TP53	ENSOANP00000020304	ENSOANP00000018980	Uncharacterized protein.	P53 domain-containing protein.	0.951