(81 nodes) Apoptosis network (Ornithorhynchus anatinus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC100093369	Uncharacterized protein; Belongs to the peptidase C1 family. (338 aa)
	LOC100093403	Uncharacterized protein; Belongs to the peptidase C1 family. (339 aa)
	CASP3	Caspase 3; Belongs to the peptidase C14A family. (285 aa)
	IKBKB	Inhibitor of nuclear factor kappa B kinase subunit beta. (757 aa)
	FASLG	Fas ligand; Belongs to the tumor necrosis factor family. (267 aa)
	PIK3R2	Uncharacterized protein. (724 aa)
	LOC100082304	Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (210 aa)
	CAPN2	Calpain 2; Belongs to the peptidase C2 family. (700 aa)
	PARP1	Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (973 aa)
	CASP7	Uncharacterized protein; Belongs to the peptidase C14A family. (302 aa)
	F7BHK4_ORNAN	Uncharacterized protein. (556 aa)
	PDPK1	Protein kinase domain-containing protein. (280 aa)
	CHUK	Protein kinase domain-containing protein. (719 aa)
	CTSD	Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family. (156 aa)
	DFFA	DNA fragmentation factor subunit alpha. (329 aa)
	F7FS79_ORNAN	Uncharacterized protein; Belongs to the peptidase C14A family. (305 aa)
	CASP6	Caspase 6; Belongs to the peptidase C14A family. (259 aa)
	ITPR1	Uncharacterized protein. (1597 aa)
	F7A3C5_ORNAN	Uncharacterized protein; Belongs to the peptidase C14A family. (487 aa)
	PIK3R1	SH2 domain-containing protein. (230 aa)
	NGF	Uncharacterized protein. (136 aa)
	CTSK	Cathepsin K; Belongs to the peptidase C1 family. (329 aa)
	CTSS	Cathepsin S; Belongs to the peptidase C1 family. (333 aa)
	F7DKQ8_ORNAN	Uncharacterized protein; Belongs to the peptidase C1 family. (340 aa)
	RELA	RHD domain-containing protein. (159 aa)
	TRAF2	RING-type domain-containing protein. (258 aa)
	FOS	Fos proto-oncogene, AP-1 transcription factor subunit. (336 aa)
	APAF1	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1250 aa)
	PIK3R3	Uncharacterized protein. (462 aa)
	DIABLO	Uncharacterized protein. (247 aa)
	MAPK10	Mitogen-activated protein kinase. (408 aa)
	PTPN13	Uncharacterized protein. (1630 aa)
	ATM	FAT domain-containing protein. (1029 aa)
	MAP3K14	Protein kinase domain-containing protein. (221 aa)
	NFKBIA	ANK_REP_REGION domain-containing protein. (329 aa)
	TUBA1B	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (451 aa)
	ACTB	Actin beta. (375 aa)
	GADD45A	Ribosomal_L7Ae domain-containing protein. (321 aa)
	CTSC	Pept_C1 domain-containing protein; Belongs to the peptidase C1 family. (409 aa)
	LOC100076077	Uncharacterized protein; Belongs to the peptidase C1 family. (338 aa)
	LOC100077443	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
	TNFSF10	Tumor necrosis factor ligand superfamily member. (299 aa)
	MAP3K5	Mitogen-activated protein kinase kinase kinase 5. (1228 aa)
	MAP2K2	Protein kinase domain-containing protein. (252 aa)
	LOC100087695	Uncharacterized protein. (556 aa)
	CSF2RB	Fibronectin type-III domain-containing protein. (387 aa)
	MAPK9	Mitogen-activated protein kinase. (429 aa)
	AKT3	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (477 aa)
	EIF2AK3	Eukaryotic translation initiation factor 2 alpha kinase 3. (1028 aa)
	LOC100077243	Uncharacterized protein. (607 aa)
	CTSL	Uncharacterized protein; Belongs to the peptidase C1 family. (234 aa)
	BID	Uncharacterized protein. (138 aa)
	LMNB1	IF rod domain-containing protein; Belongs to the intermediate filament family. (328 aa)
	TP53	P53 domain-containing protein. (87 aa)
	SPTAN1	Spectrin alpha, non-erythrocytic 1. (2479 aa)
	MAPK8	Protein kinase domain-containing protein. (338 aa)
	LMNA	IF rod domain-containing protein; Belongs to the intermediate filament family. (346 aa)
	CTSB	Pept_C1 domain-containing protein; Belongs to the peptidase C1 family. (250 aa)
	BCL2A1	BCL2 related protein A1. (175 aa)
	SPTA1	Uncharacterized protein. (737 aa)
	DFFB	DFF40 domain-containing protein. (195 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1069 aa)
	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1034 aa)
	RIPK1	Receptor interacting serine/threonine kinase 1. (612 aa)
	RAF1-2	Protein kinase domain-containing protein. (141 aa)
	F7ECP2_ORNAN	Uncharacterized protein; Belongs to the intermediate filament family. (225 aa)
	CAPN1	EF-hand domain-containing protein. (74 aa)
	EIF2S1	Eukaryotic translation initiation factor 2 subunit alpha. (315 aa)
	NFKB1	RHD domain-containing protein. (267 aa)
	CTSH	Inhibitor_I29 domain-containing protein. (68 aa)
	CTSZ	Pept_C1 domain-containing protein. (88 aa)
	ERN1-2	Uncharacterized protein. (67 aa)
	TUBA8	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (486 aa)
	CTSF	Inhibitor_I29 domain-containing protein. (160 aa)
	TRAF1-2	RING-type domain-containing protein. (115 aa)
	MAPK1	Protein kinase domain-containing protein. (150 aa)
	FAS	Death domain-containing protein. (114 aa)
	K7EEY1_ORNAN	Tubulin_C domain-containing protein; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (242 aa)
	K7EFK4_ORNAN	Tubulin domain-containing protein. (111 aa)
	ITPR2	Uncharacterized protein. (323 aa)
	AKT1	Uncharacterized protein. (230 aa)

Your Current Organism:

Ornithorhynchus anatinus

NCBI taxonomy Id: 9258
Other names: O. anatinus, Platypus anatinus, duck-billed platypus, duckbill platypus, platypus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACTB	CASP3	ENSOANP00000012287	ENSOANP00000000517	Actin beta.	Caspase 3; Belongs to the peptidase C14A family.	0.914
ACTB	CASP6	ENSOANP00000012287	ENSOANP00000005812	Actin beta.	Caspase 6; Belongs to the peptidase C14A family.	0.913
ACTB	CASP7	ENSOANP00000012287	ENSOANP00000002509	Actin beta.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.913
ACTB	F7ECP2_ORNAN	ENSOANP00000012287	ENSOANP00000026382	Actin beta.	Uncharacterized protein; Belongs to the intermediate filament family.	0.409
ACTB	K7EEY1_ORNAN	ENSOANP00000012287	ENSOANP00000032088	Actin beta.	Tubulin_C domain-containing protein; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	0.551
ACTB	K7EFK4_ORNAN	ENSOANP00000012287	ENSOANP00000032311	Actin beta.	Tubulin domain-containing protein.	0.561
ACTB	TUBA1B	ENSOANP00000012287	ENSOANP00000012268	Actin beta.	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	0.535
ACTB	TUBA8	ENSOANP00000012287	ENSOANP00000030844	Actin beta.	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	0.533
AKT1	AKT3	ENSOANP00000033007	ENSOANP00000016278	Uncharacterized protein.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.900
AKT1	CASP3	ENSOANP00000033007	ENSOANP00000000517	Uncharacterized protein.	Caspase 3; Belongs to the peptidase C14A family.	0.453
AKT1	CASP7	ENSOANP00000033007	ENSOANP00000002509	Uncharacterized protein.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.483
AKT1	CHUK	ENSOANP00000033007	ENSOANP00000003934	Uncharacterized protein.	Protein kinase domain-containing protein.	0.960
AKT1	IKBKB	ENSOANP00000033007	ENSOANP00000001111	Uncharacterized protein.	Inhibitor of nuclear factor kappa B kinase subunit beta.	0.958
AKT1	MAP3K5	ENSOANP00000033007	ENSOANP00000015019	Uncharacterized protein.	Mitogen-activated protein kinase kinase kinase 5.	0.920
AKT1	MAPK1	ENSOANP00000033007	ENSOANP00000030955	Uncharacterized protein.	Protein kinase domain-containing protein.	0.927
AKT1	PDPK1	ENSOANP00000033007	ENSOANP00000003693	Uncharacterized protein.	Protein kinase domain-containing protein.	0.982
AKT1	PIK3CA	ENSOANP00000033007	ENSOANP00000021943	Uncharacterized protein.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.963
AKT1	PIK3CB	ENSOANP00000033007	ENSOANP00000023160	Uncharacterized protein.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.949
AKT1	PIK3R1	ENSOANP00000033007	ENSOANP00000007081	Uncharacterized protein.	SH2 domain-containing protein.	0.955
AKT1	PIK3R2	ENSOANP00000033007	ENSOANP00000002083	Uncharacterized protein.	Uncharacterized protein.	0.942