(70 nodes) T cell receptor signaling pathway network (Ornithorhynchus anatinus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PPP3CB	Serine/threonine-protein phosphatase. (449 aa)
	NCK1	NCK adaptor protein 1. (315 aa)
	IKBKB	Inhibitor of nuclear factor kappa B kinase subunit beta. (757 aa)
	PIK3R2	Uncharacterized protein. (724 aa)
	GSK3B	Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (247 aa)
	MAPK14	Protein kinase domain-containing protein. (126 aa)
	PDPK1	Protein kinase domain-containing protein. (280 aa)
	PAK3	Non-specific serine/threonine protein kinase. (557 aa)
	CHUK	Protein kinase domain-containing protein. (719 aa)
	VAV2-2	Calponin-homology (CH) domain-containing protein. (127 aa)
	PPP3CA	Serine/threonine-protein phosphatase. (440 aa)
	MALT1	CASPASE_P20 domain-containing protein. (470 aa)
	CARD11	Uncharacterized protein. (1156 aa)
	PIK3R1	SH2 domain-containing protein. (230 aa)
	RELA	RHD domain-containing protein. (159 aa)
	FOS	Fos proto-oncogene, AP-1 transcription factor subunit. (336 aa)
	ITK	Tyrosine-protein kinase. (627 aa)
	CD28	IGv domain-containing protein. (178 aa)
	CD3G	CD3g molecule. (177 aa)
	F6X8T6_ORNAN	Uncharacterized protein. (163 aa)
	F6Q149_ORNAN	Ig-like domain-containing protein. (117 aa)
	TEC	Tyrosine-protein kinase. (585 aa)
	PIK3R3	Uncharacterized protein. (462 aa)
	IFNG	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (167 aa)
	MAP3K8	Mitogen-activated protein kinase kinase kinase 8. (468 aa)
	MAPK10	Mitogen-activated protein kinase. (408 aa)
	BCL10	BCL10 immune signaling adaptor. (217 aa)
	MAP3K14	Protein kinase domain-containing protein. (221 aa)
	NFKBIA	ANK_REP_REGION domain-containing protein. (329 aa)
	ICOS	IGv domain-containing protein. (214 aa)
	CBLB	Cbl proto-oncogene B. (985 aa)
	LCP2	Lymphocyte cytosolic protein 2. (530 aa)
	PPP3R1	Uncharacterized protein. (180 aa)
	PAK5	Non-specific serine/threonine protein kinase. (735 aa)
	NFATC2	Nuclear factor of activated T cells 2. (929 aa)
	DLG1	Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (798 aa)
	MAP3K7	Protein kinase domain-containing protein. (506 aa)
	PAK2	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (388 aa)
	MAP2K2	Protein kinase domain-containing protein. (252 aa)
	IL10	Interleukin 10. (181 aa)
	MAPK13	Mitogen-activated protein kinase. (376 aa)
	MAPK9	Mitogen-activated protein kinase. (429 aa)
	AKT3	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (477 aa)
	CDC42	Cell division cycle 42. (183 aa)
	LOC103171163	Ig-like domain-containing protein. (219 aa)
	F7B3N3_ORNAN	Ig-like domain-containing protein. (200 aa)
	PPP3CC	Serine/threonine-protein phosphatase. (514 aa)
	CTLA4	Cytotoxic T-lymphocyte associated protein 4. (225 aa)
	MAPK8	Protein kinase domain-containing protein. (338 aa)
	FYN	Tyrosine-protein kinase. (455 aa)
	PTPN6	Protein tyrosine phosphatase non-receptor type 6. (420 aa)
	RHOA	Uncharacterized protein. (201 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1069 aa)
	SOS2	SOS Ras/Rho guanine nucleotide exchange factor 2. (1333 aa)
	NCK2	Uncharacterized protein. (317 aa)
	PTPRC	Uncharacterized protein. (548 aa)
	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1034 aa)
	VAV1	Uncharacterized protein. (454 aa)
	SOS1	SOS Ras/Rac guanine nucleotide exchange factor 1. (1214 aa)
	PRKCQ	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (708 aa)
	RAF1-2	Protein kinase domain-containing protein. (141 aa)
	VAV3	Uncharacterized protein. (171 aa)
	PLCG1	Uncharacterized protein. (265 aa)
	NFATC3	RHD domain-containing protein. (648 aa)
	NFKB1	RHD domain-containing protein. (267 aa)
	PDCD1	Ig-like domain-containing protein. (199 aa)
	MAPK1	Protein kinase domain-containing protein. (150 aa)
	NFATC1	Uncharacterized protein. (345 aa)
	RASGRP1	Ras-GEF domain-containing protein. (158 aa)
	AKT1	Uncharacterized protein. (230 aa)

Your Current Organism:

Ornithorhynchus anatinus

NCBI taxonomy Id: 9258
Other names: O. anatinus, Platypus anatinus, duck-billed platypus, duckbill platypus, platypus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKT1	AKT3	ENSOANP00000033007	ENSOANP00000016278	Uncharacterized protein.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.900
AKT1	CDC42	ENSOANP00000033007	ENSOANP00000016321	Uncharacterized protein.	Cell division cycle 42.	0.481
AKT1	CHUK	ENSOANP00000033007	ENSOANP00000003934	Uncharacterized protein.	Protein kinase domain-containing protein.	0.960
AKT1	FYN	ENSOANP00000033007	ENSOANP00000019262	Uncharacterized protein.	Tyrosine-protein kinase.	0.404
AKT1	GSK3B	ENSOANP00000033007	ENSOANP00000002674	Uncharacterized protein.	Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily.	0.957
AKT1	IKBKB	ENSOANP00000033007	ENSOANP00000001111	Uncharacterized protein.	Inhibitor of nuclear factor kappa B kinase subunit beta.	0.958
AKT1	MAP3K8	ENSOANP00000033007	ENSOANP00000009626	Uncharacterized protein.	Mitogen-activated protein kinase kinase kinase 8.	0.945
AKT1	MAPK1	ENSOANP00000033007	ENSOANP00000030955	Uncharacterized protein.	Protein kinase domain-containing protein.	0.927
AKT1	MAPK13	ENSOANP00000033007	ENSOANP00000015830	Uncharacterized protein.	Mitogen-activated protein kinase.	0.924
AKT1	MAPK14	ENSOANP00000033007	ENSOANP00000002815	Uncharacterized protein.	Protein kinase domain-containing protein.	0.927
AKT1	PDPK1	ENSOANP00000033007	ENSOANP00000003693	Uncharacterized protein.	Protein kinase domain-containing protein.	0.982
AKT1	PIK3CA	ENSOANP00000033007	ENSOANP00000021943	Uncharacterized protein.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.963
AKT1	PIK3CB	ENSOANP00000033007	ENSOANP00000023160	Uncharacterized protein.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.949
AKT1	PIK3R1	ENSOANP00000033007	ENSOANP00000007081	Uncharacterized protein.	SH2 domain-containing protein.	0.955
AKT1	PIK3R2	ENSOANP00000033007	ENSOANP00000002083	Uncharacterized protein.	Uncharacterized protein.	0.942
AKT1	PIK3R3	ENSOANP00000033007	ENSOANP00000009424	Uncharacterized protein.	Uncharacterized protein.	0.949
AKT1	RAF1-2	ENSOANP00000033007	ENSOANP00000025744	Uncharacterized protein.	Protein kinase domain-containing protein.	0.944
AKT1	RELA	ENSOANP00000033007	ENSOANP00000007630	Uncharacterized protein.	RHD domain-containing protein.	0.465
AKT3	AKT1	ENSOANP00000016278	ENSOANP00000033007	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.900
AKT3	CDC42	ENSOANP00000016278	ENSOANP00000016321	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Cell division cycle 42.	0.481