(70 nodes) Circadian entrainment network (Ornithorhynchus anatinus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	KCNJ9	Potassium voltage-gated channel subfamily J member 9. (407 aa)
	GNG13	G protein subunit gamma 13. (67 aa)
	KCNJ5	Potassium voltage-gated channel subfamily J member 5. (319 aa)
	ADCY7	Guanylate cyclase domain-containing protein. (322 aa)
	RASD1	Ras related dexamethasone induced 1. (278 aa)
	GRIN2B	Uncharacterized protein. (554 aa)
	PLCB2	PH_14 domain-containing protein. (170 aa)
	GNG3	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
	CALM1	Uncharacterized protein; Belongs to the calmodulin family. (113 aa)
	GNAI3	G protein subunit alpha i3. (236 aa)
	CAMK2A	Calcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily. (492 aa)
	GNG7	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
	PER2	Period circadian regulator 2. (1325 aa)
	GNAI1	G protein subunit alpha i1. (302 aa)
	ITPR1	Uncharacterized protein. (1597 aa)
	ADCY10	Uncharacterized protein. (1035 aa)
	GRIA3	Glutamate ionotropic receptor AMPA type subunit 3. (890 aa)
	GNAO1-2	Uncharacterized protein. (115 aa)
	GNB4	G protein subunit beta 4. (340 aa)
	FOS	Fos proto-oncogene, AP-1 transcription factor subunit. (336 aa)
	GRIA1	Glutamate ionotropic receptor AMPA type subunit 1. (900 aa)
	GNAI2	Uncharacterized protein. (199 aa)
	ADCY9	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (376 aa)
	KCNJ3	Potassium voltage-gated channel subfamily J member 3. (496 aa)
	PRKACA	Protein kinase cAMP-activated catalytic subunit alpha. (312 aa)
	GNB1	G protein subunit beta 1. (340 aa)
	KCNJ6	Potassium voltage-gated channel subfamily J member 6. (423 aa)
	GRIN2A	Glutamate ionotropic receptor NMDA type subunit 2A. (1452 aa)
	PRKCA	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (597 aa)
	ADCY8	Adenylate cyclase 8; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (953 aa)
	PLCB1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1096 aa)
	GNAS	Uncharacterized protein. (335 aa)
	PRKCG	Uncharacterized protein. (304 aa)
	RYR3	Uncharacterized protein. (2798 aa)
	CREB1	BZIP domain-containing protein. (47 aa)
	GUCY1A2	Guanylate cyclase 1 soluble subunit alpha 2; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (630 aa)
	GRIA4	Uncharacterized protein. (679 aa)
	ADCY2	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1020 aa)
	GPR50	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (349 aa)
	GNB5	WD_REPEATS_REGION domain-containing protein. (187 aa)
	PLCB3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1122 aa)
	MTNR1A	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (345 aa)
	PRKG2	Uncharacterized protein. (293 aa)
	GRIN1	Uncharacterized protein. (532 aa)
	CALML4	Calmodulin like 4. (191 aa)
	GNG2	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (71 aa)
	CACNA1D	Ca_chan_IQ domain-containing protein. (938 aa)
	PRKACB	Uncharacterized protein. (243 aa)
	ADCY4	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (92 aa)
	RPS6KA5	Non-specific serine/threonine protein kinase. (677 aa)
	LOC103165382	Uncharacterized protein; Belongs to the calmodulin family. (149 aa)
	F6W653_ORNAN	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (744 aa)
	GRIA2	Glutamate ionotropic receptor AMPA type subunit 2. (883 aa)
	GUCY1A1	Guanylate cyclase 1 soluble subunit alpha 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (690 aa)
	PLCB4	Phosphoinositide phospholipase C. (938 aa)
	GNG5	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
	GUCY1B1	Guanylate cyclase 1 soluble subunit beta 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (595 aa)
	ADCY6	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (574 aa)
	NOS1	Flavodoxin-like domain-containing protein. (301 aa)
	RYR2-2	Uncharacterized protein. (45 aa)
	K7E8T1_ORNAN	Uncharacterized protein. (112 aa)
	ADCY3	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (123 aa)
	GNB3	WD_REPEATS_REGION domain-containing protein. (129 aa)
	CACNA1C	Ion_trans domain-containing protein. (156 aa)
	CACNA1G-2	Uncharacterized protein. (235 aa)
	CACNA1H	Ion_trans domain-containing protein. (257 aa)
	MAPK1	Protein kinase domain-containing protein. (150 aa)
	GRIN2D	ANF_receptor domain-containing protein. (300 aa)
	ADCY1	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (118 aa)
	RYR1	Uncharacterized protein. (283 aa)

Your Current Organism:

Ornithorhynchus anatinus

NCBI taxonomy Id: 9258
Other names: O. anatinus, Platypus anatinus, duck-billed platypus, duckbill platypus, platypus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADCY1	ADCY3	ENSOANP00000032725	ENSOANP00000029991	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.911
ADCY1	ADCY6	ENSOANP00000032725	ENSOANP00000027036	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.910
ADCY1	ADCY8	ENSOANP00000032725	ENSOANP00000012883	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Adenylate cyclase 8; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.901
ADCY1	ADCY9	ENSOANP00000032725	ENSOANP00000009309	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.925
ADCY1	CALM1	ENSOANP00000032725	ENSOANP00000002731	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Uncharacterized protein; Belongs to the calmodulin family.	0.907
ADCY1	CALML4	ENSOANP00000032725	ENSOANP00000021365	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Calmodulin like 4.	0.907
ADCY1	CAMK2A	ENSOANP00000032725	ENSOANP00000003646	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Calcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily.	0.902
ADCY1	GNAI1	ENSOANP00000032725	ENSOANP00000005524	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	G protein subunit alpha i1.	0.738
ADCY1	GNAI2	ENSOANP00000032725	ENSOANP00000008705	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Uncharacterized protein.	0.738
ADCY1	GNAI3	ENSOANP00000032725	ENSOANP00000003587	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	G protein subunit alpha i3.	0.738
ADCY1	GNAO1-2	ENSOANP00000032725	ENSOANP00000006644	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Uncharacterized protein.	0.925
ADCY1	GNAS	ENSOANP00000032725	ENSOANP00000014762	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Uncharacterized protein.	0.938
ADCY1	GNB1	ENSOANP00000032725	ENSOANP00000010184	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	G protein subunit beta 1.	0.710
ADCY1	GNB3	ENSOANP00000032725	ENSOANP00000030185	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	WD_REPEATS_REGION domain-containing protein.	0.710
ADCY1	GNB4	ENSOANP00000032725	ENSOANP00000007438	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	G protein subunit beta 4.	0.710
ADCY1	GNB5	ENSOANP00000032725	ENSOANP00000019325	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	WD_REPEATS_REGION domain-containing protein.	0.710
ADCY1	GNG13	ENSOANP00000032725	ENSOANP00000000743	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	G protein subunit gamma 13.	0.711
ADCY1	GNG2	ENSOANP00000032725	ENSOANP00000022007	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.711
ADCY1	GNG3	ENSOANP00000032725	ENSOANP00000002492	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.711
ADCY1	GNG5	ENSOANP00000032725	ENSOANP00000026734	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.711