(45 nodes) Long-term potentiation network (Ornithorhynchus anatinus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PPP3CB	Serine/threonine-protein phosphatase. (449 aa)
	GRIN2B	Uncharacterized protein. (554 aa)
	PLCB2	PH_14 domain-containing protein. (170 aa)
	CALM1	Uncharacterized protein; Belongs to the calmodulin family. (113 aa)
	GRM1	G_PROTEIN_RECEP_F3_4 domain-containing protein. (781 aa)
	CAMK2A	Calcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily. (492 aa)
	PPP3CA	Serine/threonine-protein phosphatase. (440 aa)
	ITPR1	Uncharacterized protein. (1597 aa)
	PPP1CC	Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (324 aa)
	GRIA1	Glutamate ionotropic receptor AMPA type subunit 1. (900 aa)
	RPS6KA6	Non-specific serine/threonine protein kinase. (714 aa)
	RAP1B	RAP1B, member of RAS oncogene family. (184 aa)
	PRKACA	Protein kinase cAMP-activated catalytic subunit alpha. (312 aa)
	GRIN2A	Glutamate ionotropic receptor NMDA type subunit 2A. (1452 aa)
	PRKCA	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (597 aa)
	ADCY8	Adenylate cyclase 8; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (953 aa)
	PPP3R1	Uncharacterized protein. (180 aa)
	PLCB1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1096 aa)
	GRM5	Glutamate metabotropic receptor 5. (1185 aa)
	PRKCG	Uncharacterized protein. (304 aa)
	MAP2K2	Protein kinase domain-containing protein. (252 aa)
	RPS6KA3	Non-specific serine/threonine protein kinase. (712 aa)
	PPP3CC	Serine/threonine-protein phosphatase. (514 aa)
	PLCB3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1122 aa)
	GRIN1	Uncharacterized protein. (532 aa)
	BRAF	B-Raf proto-oncogene, serine/threonine kinase. (702 aa)
	CALML4	Calmodulin like 4. (191 aa)
	PRKACB	Uncharacterized protein. (243 aa)
	PPP1CB	Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (327 aa)
	CAMK4	Calcium/calmodulin dependent protein kinase IV; Belongs to the protein kinase superfamily. (434 aa)
	LOC103165382	Uncharacterized protein; Belongs to the calmodulin family. (149 aa)
	GRIA2	Glutamate ionotropic receptor AMPA type subunit 2. (883 aa)
	RPS6KA2	Protein kinase domain-containing protein. (173 aa)
	RAF1-2	Protein kinase domain-containing protein. (141 aa)
	PLCB4	Phosphoinositide phospholipase C. (938 aa)
	EP300	E1A binding protein p300. (2421 aa)
	PPP1R1A	Uncharacterized protein. (154 aa)
	K7E8T1_ORNAN	Uncharacterized protein. (112 aa)
	PPP1CA	Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (319 aa)
	CACNA1C	Ion_trans domain-containing protein. (156 aa)
	MAPK1	Protein kinase domain-containing protein. (150 aa)
	GRIN2D	ANF_receptor domain-containing protein. (300 aa)
	ITPR2	Uncharacterized protein. (323 aa)
	ADCY1	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (118 aa)
	RAPGEF3	Uncharacterized protein. (131 aa)

Your Current Organism:

Ornithorhynchus anatinus

NCBI taxonomy Id: 9258
Other names: O. anatinus, Platypus anatinus, duck-billed platypus, duckbill platypus, platypus

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADCY1	ADCY8	ENSOANP00000032725	ENSOANP00000012883	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Adenylate cyclase 8; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.901
ADCY1	CALM1	ENSOANP00000032725	ENSOANP00000002731	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Uncharacterized protein; Belongs to the calmodulin family.	0.907
ADCY1	CALML4	ENSOANP00000032725	ENSOANP00000021365	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Calmodulin like 4.	0.907
ADCY1	CAMK2A	ENSOANP00000032725	ENSOANP00000003646	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Calcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily.	0.902
ADCY1	CAMK4	ENSOANP00000032725	ENSOANP00000023869	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Calcium/calmodulin dependent protein kinase IV; Belongs to the protein kinase superfamily.	0.901
ADCY1	LOC103165382	ENSOANP00000032725	ENSOANP00000024340	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Uncharacterized protein; Belongs to the calmodulin family.	0.907
ADCY1	PRKACA	ENSOANP00000032725	ENSOANP00000010075	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Protein kinase cAMP-activated catalytic subunit alpha.	0.914
ADCY1	PRKACB	ENSOANP00000032725	ENSOANP00000022714	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Uncharacterized protein.	0.914
ADCY1	PRKCA	ENSOANP00000032725	ENSOANP00000012813	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.901
ADCY1	PRKCG	ENSOANP00000032725	ENSOANP00000014905	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Uncharacterized protein.	0.901
ADCY1	RAPGEF3	ENSOANP00000032725	ENSOANP00000032741	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Uncharacterized protein.	0.906
ADCY8	ADCY1	ENSOANP00000012883	ENSOANP00000032725	Adenylate cyclase 8; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.901
ADCY8	CALM1	ENSOANP00000012883	ENSOANP00000002731	Adenylate cyclase 8; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Uncharacterized protein; Belongs to the calmodulin family.	0.942
ADCY8	CALML4	ENSOANP00000012883	ENSOANP00000021365	Adenylate cyclase 8; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Calmodulin like 4.	0.911
ADCY8	CAMK2A	ENSOANP00000012883	ENSOANP00000003646	Adenylate cyclase 8; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Calcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily.	0.907
ADCY8	CAMK4	ENSOANP00000012883	ENSOANP00000023869	Adenylate cyclase 8; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Calcium/calmodulin dependent protein kinase IV; Belongs to the protein kinase superfamily.	0.906
ADCY8	GRIN2A	ENSOANP00000012883	ENSOANP00000011389	Adenylate cyclase 8; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Glutamate ionotropic receptor NMDA type subunit 2A.	0.522
ADCY8	LOC103165382	ENSOANP00000012883	ENSOANP00000024340	Adenylate cyclase 8; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Uncharacterized protein; Belongs to the calmodulin family.	0.942
ADCY8	PRKACA	ENSOANP00000012883	ENSOANP00000010075	Adenylate cyclase 8; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Protein kinase cAMP-activated catalytic subunit alpha.	0.930
ADCY8	PRKACB	ENSOANP00000012883	ENSOANP00000022714	Adenylate cyclase 8; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Uncharacterized protein.	0.930