(70 nodes) Inflammatory mediator regulation of TRP channels network (Ornithorhynchus anatinus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PTGER4	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (293 aa)
	ADCY7	Guanylate cyclase domain-containing protein. (322 aa)
	ASIC3	Acid sensing ion channel subunit 3; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (455 aa)
	HRH1	Histamine receptor H1; Belongs to the G-protein coupled receptor 1 family. (502 aa)
	PLA2G4A	Phospholipase A2. (749 aa)
	PIK3R2	Uncharacterized protein. (724 aa)
	PLCB2	PH_14 domain-containing protein. (170 aa)
	CALM1	Uncharacterized protein; Belongs to the calmodulin family. (113 aa)
	MAPK14	Protein kinase domain-containing protein. (126 aa)
	CAMK2A	Calcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily. (492 aa)
	F6TGT3_ORNAN	ANK_REP_REGION domain-containing protein; Belongs to the transient receptor (TC 1.A.4) family. (596 aa)
	ITPR1	Uncharacterized protein. (1597 aa)
	PIK3R1	SH2 domain-containing protein. (230 aa)
	NGF	Uncharacterized protein. (136 aa)
	PPP1CC	Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (324 aa)
	IGF1	Insulin like growth factor 1. (153 aa)
	ADCY9	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (376 aa)
	PIK3R3	Uncharacterized protein. (462 aa)
	MAPK10	Mitogen-activated protein kinase. (408 aa)
	PRKACA	Protein kinase cAMP-activated catalytic subunit alpha. (312 aa)
	BDKRB1	Bradykinin receptor B1; Belongs to the G-protein coupled receptor 1 family. (355 aa)
	BDKRB2	Bradykinin receptor B2; Belongs to the G-protein coupled receptor 1 family. (377 aa)
	MAP2K3	Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (347 aa)
	PRKCA	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (597 aa)
	ADCY8	Adenylate cyclase 8; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (953 aa)
	PLCB1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1096 aa)
	GNAS	Uncharacterized protein. (335 aa)
	HTR2B	5-hydroxytryptamine receptor 2B. (482 aa)
	PRKCG	Uncharacterized protein. (304 aa)
	F6ST99_ORNAN	Uncharacterized protein. (542 aa)
	LOC103170826	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (347 aa)
	MAPK13	Mitogen-activated protein kinase. (376 aa)
	MAPK9	Mitogen-activated protein kinase. (429 aa)
	IL1B	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (290 aa)
	PRKCE	C2 domain-containing protein. (126 aa)
	IL1R1	Interleukin 1 receptor type 1. (573 aa)
	ADCY2	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1020 aa)
	MAPK8	Protein kinase domain-containing protein. (338 aa)
	TRPV1	Transient receptor potential cation channel subfamily V member 1; Belongs to the transient receptor (TC 1.A.4) family. (851 aa)
	TRPV3	Transient receptor potential cation channel subfamily V member 3; Belongs to the transient receptor (TC 1.A.4) family. (792 aa)
	TRPM8	Transient receptor potential cation channel subfamily M member 8. (1096 aa)
	PLCB3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1122 aa)
	TRPA1	Transient receptor potential cation channel subfamily A member 1; Belongs to the transient receptor (TC 1.A.4) family. (1079 aa)
	CALML4	Calmodulin like 4. (191 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1069 aa)
	PTGER2	Prostaglandin E receptor 2; Belongs to the G-protein coupled receptor 1 family. (346 aa)
	PRKACB	Uncharacterized protein. (243 aa)
	PPP1CB	Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (327 aa)
	P2RY2	Purinergic receptor P2Y2; Belongs to the G-protein coupled receptor 1 family. (323 aa)
	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1034 aa)
	ADCY4	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (92 aa)
	PRKCQ	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (708 aa)
	LOC103165382	Uncharacterized protein; Belongs to the calmodulin family. (149 aa)
	HTR2A	5-hydroxytryptamine receptor 2A. (468 aa)
	ASIC5	Pept_C1 domain-containing protein; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (703 aa)
	F2RL1	F2R like trypsin receptor 1. (393 aa)
	PLCB4	Phosphoinositide phospholipase C. (938 aa)
	PLCG1	Uncharacterized protein. (265 aa)
	ADCY6	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (574 aa)
	K7E863_ORNAN	Lipoxygenase domain-containing protein. (60 aa)
	PLCG2	SH2 domain-containing protein. (238 aa)
	K7E8T1_ORNAN	Uncharacterized protein. (112 aa)
	ADCY3	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (123 aa)
	PPP1CA	Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (319 aa)
	ASIC2	Uncharacterized protein. (77 aa)
	PLA2G4E	cPLA2_C2 domain-containing protein. (178 aa)
	KNG1	Cystatin domain-containing protein. (133 aa)
	ASIC4	Uncharacterized protein; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (188 aa)
	ITPR2	Uncharacterized protein. (323 aa)
	ADCY1	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (118 aa)

Your Current Organism:

Ornithorhynchus anatinus

NCBI taxonomy Id: 9258
Other names: O. anatinus, Platypus anatinus, duck-billed platypus, duckbill platypus, platypus

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADCY1	ADCY3	ENSOANP00000032725	ENSOANP00000029991	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.911
ADCY1	ADCY6	ENSOANP00000032725	ENSOANP00000027036	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.910
ADCY1	ADCY8	ENSOANP00000032725	ENSOANP00000012883	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Adenylate cyclase 8; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.901
ADCY1	ADCY9	ENSOANP00000032725	ENSOANP00000009309	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.925
ADCY1	CALM1	ENSOANP00000032725	ENSOANP00000002731	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Uncharacterized protein; Belongs to the calmodulin family.	0.907
ADCY1	CALML4	ENSOANP00000032725	ENSOANP00000021365	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Calmodulin like 4.	0.907
ADCY1	CAMK2A	ENSOANP00000032725	ENSOANP00000003646	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Calcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily.	0.902
ADCY1	GNAS	ENSOANP00000032725	ENSOANP00000014762	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Uncharacterized protein.	0.938
ADCY1	LOC103165382	ENSOANP00000032725	ENSOANP00000024340	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Uncharacterized protein; Belongs to the calmodulin family.	0.907
ADCY1	PRKACA	ENSOANP00000032725	ENSOANP00000010075	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Protein kinase cAMP-activated catalytic subunit alpha.	0.914
ADCY1	PRKACB	ENSOANP00000032725	ENSOANP00000022714	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Uncharacterized protein.	0.914
ADCY1	PRKCA	ENSOANP00000032725	ENSOANP00000012813	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.901
ADCY1	PRKCG	ENSOANP00000032725	ENSOANP00000014905	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Uncharacterized protein.	0.901
ADCY2	ADCY3	ENSOANP00000018351	ENSOANP00000029991	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.434
ADCY2	ADCY6	ENSOANP00000018351	ENSOANP00000027036	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.701
ADCY2	ADCY7	ENSOANP00000018351	ENSOANP00000000930	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Guanylate cyclase domain-containing protein.	0.427
ADCY2	ADCY8	ENSOANP00000018351	ENSOANP00000012883	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase 8; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.466
ADCY2	ADCY9	ENSOANP00000018351	ENSOANP00000009309	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.506
ADCY2	CALM1	ENSOANP00000018351	ENSOANP00000002731	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Uncharacterized protein; Belongs to the calmodulin family.	0.739
ADCY2	CALML4	ENSOANP00000018351	ENSOANP00000021365	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calmodulin like 4.	0.678