(36 nodes) Ovarian steroidogenesis network (Ornithorhynchus anatinus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CGA	Glycoprotein hormones alpha chain; Belongs to the glycoprotein hormones subunit alpha family. (121 aa)
	ADCY7	Guanylate cyclase domain-containing protein. (322 aa)
	PTGS2	Prostaglandin-endoperoxide synthase 2. (604 aa)
	PLA2G4A	Phospholipase A2. (749 aa)
	LOC100091117	Uncharacterized protein. (466 aa)
	SCARB1	Scavenger receptor class B member 1; Belongs to the CD36 family. (509 aa)
	INSR	Recep_L_domain domain-containing protein. (180 aa)
	CYP1A1	Uncharacterized protein; Belongs to the cytochrome P450 family. (519 aa)
	CYP1B1	Uncharacterized protein; Belongs to the cytochrome P450 family. (195 aa)
	IGF1	Insulin like growth factor 1. (153 aa)
	ADCY9	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (376 aa)
	PRKACA	Protein kinase cAMP-activated catalytic subunit alpha. (312 aa)
	BMP6	TGF_BETA_2 domain-containing protein. (155 aa)
	ADCY8	Adenylate cyclase 8; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (953 aa)
	GNAS	Uncharacterized protein. (335 aa)
	F6ST99_ORNAN	Uncharacterized protein. (542 aa)
	CYP19A1	Cytochrome P450 family 19 subfamily A member 1; Belongs to the cytochrome P450 family. (477 aa)
	FSHB	Follicle stimulating hormone subunit beta. (129 aa)
	HSD17B2	Hydroxysteroid 17-beta dehydrogenase 2; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (390 aa)
	ADCY2	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1020 aa)
	STAR	Steroidogenic acute regulatory protein, mitochondrial; Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone. (288 aa)
	BMP15	TGF_BETA_2 domain-containing protein. (359 aa)
	PRKACB	Uncharacterized protein. (243 aa)
	ADCY4	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (92 aa)
	LOC100085065	Aldo_ket_red domain-containing protein. (324 aa)
	F7C012_ORNAN	Aldo_ket_red domain-containing protein. (328 aa)
	F6PMG7_ORNAN	Aldo_ket_red domain-containing protein. (112 aa)
	ADCY6	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (574 aa)
	LDLR	Low density lipoprotein receptor. (872 aa)
	ALOX5	Lipoxygenase domain-containing protein. (110 aa)
	K7E8Y0_ORNAN	Uncharacterized protein. (162 aa)
	ADCY3	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (123 aa)
	K7E974_ORNAN	3Beta_HSD domain-containing protein; Belongs to the 3-beta-HSD family. (369 aa)
	IGF1R	Recep_L_domain domain-containing protein. (214 aa)
	PLA2G4E	cPLA2_C2 domain-containing protein. (178 aa)
	ADCY1	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (118 aa)

Your Current Organism:

Ornithorhynchus anatinus

NCBI taxonomy Id: 9258
Other names: O. anatinus, Platypus anatinus, duck-billed platypus, duckbill platypus, platypus

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADCY1	ADCY3	ENSOANP00000032725	ENSOANP00000029991	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.911
ADCY1	ADCY6	ENSOANP00000032725	ENSOANP00000027036	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.910
ADCY1	ADCY8	ENSOANP00000032725	ENSOANP00000012883	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Adenylate cyclase 8; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.901
ADCY1	ADCY9	ENSOANP00000032725	ENSOANP00000009309	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.925
ADCY1	GNAS	ENSOANP00000032725	ENSOANP00000014762	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Uncharacterized protein.	0.938
ADCY1	PRKACA	ENSOANP00000032725	ENSOANP00000010075	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Protein kinase cAMP-activated catalytic subunit alpha.	0.914
ADCY1	PRKACB	ENSOANP00000032725	ENSOANP00000022714	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Uncharacterized protein.	0.914
ADCY2	ADCY3	ENSOANP00000018351	ENSOANP00000029991	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.434
ADCY2	ADCY6	ENSOANP00000018351	ENSOANP00000027036	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.701
ADCY2	ADCY7	ENSOANP00000018351	ENSOANP00000000930	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Guanylate cyclase domain-containing protein.	0.427
ADCY2	ADCY8	ENSOANP00000018351	ENSOANP00000012883	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase 8; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.466
ADCY2	ADCY9	ENSOANP00000018351	ENSOANP00000009309	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.506
ADCY2	GNAS	ENSOANP00000018351	ENSOANP00000014762	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Uncharacterized protein.	0.970
ADCY2	PRKACA	ENSOANP00000018351	ENSOANP00000010075	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Protein kinase cAMP-activated catalytic subunit alpha.	0.924
ADCY2	PRKACB	ENSOANP00000018351	ENSOANP00000022714	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Uncharacterized protein.	0.924
ADCY3	ADCY1	ENSOANP00000029991	ENSOANP00000032725	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.911
ADCY3	ADCY2	ENSOANP00000029991	ENSOANP00000018351	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.434
ADCY3	ADCY6	ENSOANP00000029991	ENSOANP00000027036	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.941
ADCY3	ADCY7	ENSOANP00000029991	ENSOANP00000000930	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Guanylate cyclase domain-containing protein.	0.946
ADCY3	ADCY8	ENSOANP00000029991	ENSOANP00000012883	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Adenylate cyclase 8; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.957