STRINGSTRING
PDE4B PDE4B ADCY7 ADCY7 PLCB2 PLCB2 MMP16 MMP16 GNAI3 GNAI3 PTHLH PTHLH FGFR1 FGFR1 GNA11 GNA11 GNAI1 GNAI1 AKAP13 AKAP13 ITPR1 ITPR1 RXRA RXRA GNA12 GNA12 TNFSF11 TNFSF11 CREB3L2 CREB3L2 FOS FOS GNAI2 GNAI2 ADCY9 ADCY9 NR4A2 NR4A2 PRKACA PRKACA LRP6 LRP6 GCM2 GCM2 MMP25 MMP25 PRKCA PRKCA ADCY8 ADCY8 RUNX2 RUNX2 PLCB1 PLCB1 ATF2 ATF2 CREB5 CREB5 GNAS GNAS PRKCG PRKCG MMP24 MMP24 SLC34A1 SLC34A1 CREB1 CREB1 CASR CASR F7B3E4_ORNAN F7B3E4_ORNAN EGFR EGFR JUND JUND ADCY2 ADCY2 PDE4D PDE4D PLCB3 PLCB3 CREB3L3 CREB3L3 BRAF BRAF RHOA RHOA PRKACB PRKACB ADCY4 ADCY4 KL KL F7CEG3_ORNAN F7CEG3_ORNAN RAF1-2 RAF1-2 PLCB4 PLCB4 MMP17 MMP17 F7F710_ORNAN F7F710_ORNAN ADCY6 ADCY6 MEF2D MEF2D ARHGEF11 ARHGEF11 PDE4A PDE4A K7E8T1_ORNAN K7E8T1_ORNAN PLD1 PLD1 ADCY3 ADCY3 MAPK1 MAPK1 ITPR2 ITPR2 ADCY1 ADCY1 ARRB1 ARRB1 PLD2 PLD2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PDE4BPDEase domain-containing protein. (212 aa)
ADCY7Guanylate cyclase domain-containing protein. (322 aa)
PLCB2PH_14 domain-containing protein. (170 aa)
MMP16Matrix metallopeptidase 16. (607 aa)
GNAI3G protein subunit alpha i3. (236 aa)
PTHLHParathyroid hormone like hormone. (177 aa)
FGFR1Fibroblast growth factor receptor. (821 aa)
GNA11G protein subunit alpha 11. (198 aa)
GNAI1G protein subunit alpha i1. (302 aa)
AKAP13Uncharacterized protein. (727 aa)
ITPR1Uncharacterized protein. (1597 aa)
RXRARetinoid X receptor alpha. (433 aa)
GNA12G protein subunit alpha 12. (281 aa)
TNFSF11TNF superfamily member 11; Belongs to the tumor necrosis factor family. (244 aa)
CREB3L2Uncharacterized protein. (177 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (336 aa)
GNAI2Uncharacterized protein. (199 aa)
ADCY9Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (376 aa)
NR4A2Nuclear receptor subfamily 4 group A member 2. (518 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha. (312 aa)
LRP6LDL receptor related protein 6. (1462 aa)
GCM2Glial cells missing transcription factor 2. (491 aa)
MMP25Matrix metallopeptidase 25. (528 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (597 aa)
ADCY8Adenylate cyclase 8; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (953 aa)
RUNX2Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (380 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1096 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
CREB5Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (499 aa)
GNASUncharacterized protein. (335 aa)
PRKCGUncharacterized protein. (304 aa)
MMP24Peptidase_M10 domain-containing protein. (77 aa)
SLC34A1Solute carrier family 34 member 1. (519 aa)
CREB1BZIP domain-containing protein. (47 aa)
CASRCalcium sensing receptor. (1084 aa)
F7B3E4_ORNANZnMc domain-containing protein. (474 aa)
EGFRReceptor protein-tyrosine kinase. (1215 aa)
JUNDBZIP domain-containing protein. (117 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1020 aa)
PDE4DPDEase domain-containing protein. (276 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1122 aa)
CREB3L3cAMP responsive element binding protein 3 like 3. (352 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (702 aa)
RHOAUncharacterized protein. (201 aa)
PRKACBUncharacterized protein. (243 aa)
ADCY4Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (92 aa)
KLKlotho; Belongs to the glycosyl hydrolase 1 family. (739 aa)
F7CEG3_ORNANUncharacterized protein; Belongs to the cytochrome P450 family. (237 aa)
RAF1-2Protein kinase domain-containing protein. (141 aa)
PLCB4Phosphoinositide phospholipase C. (938 aa)
MMP17ZnMc domain-containing protein. (272 aa)
F7F710_ORNANZnMc domain-containing protein. (305 aa)
ADCY6Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (574 aa)
MEF2DHJURP_C domain-containing protein. (197 aa)
ARHGEF11RGS-like domain-containing protein. (109 aa)
PDE4APDEase domain-containing protein. (182 aa)
K7E8T1_ORNANUncharacterized protein. (112 aa)
PLD1PH domain-containing protein. (156 aa)
ADCY3Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (123 aa)
MAPK1Protein kinase domain-containing protein. (150 aa)
ITPR2Uncharacterized protein. (323 aa)
ADCY1Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (118 aa)
ARRB1Arrestin_C domain-containing protein. (151 aa)
PLD2PX domain-containing protein. (145 aa)
Your Current Organism:
Ornithorhynchus anatinus
NCBI taxonomy Id: 9258
Other names: O. anatinus, Platypus anatinus, duck-billed platypus, duckbill platypus, platypus
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