STRINGSTRING
CASP3 CASP3 VPS11 VPS11 IKBKB IKBKB KLC1 KLC1 LOC100088508 LOC100088508 MYO6 MYO6 ARPC5 ARPC5 VPS18 VPS18 SKP1 SKP1 MYD88 MYD88 PYCARD PYCARD M6PR M6PR CASP7 CASP7 TCF7L2 TCF7L2 MAPK14 MAPK14 IRAK4 IRAK4 PAK3 PAK3 CHUK CHUK RAB9A RAB9A ROCK2 ROCK2 RAC1 RAC1 CYTH3 CYTH3 PIK3C3 PIK3C3 CYTH1 CYTH1 EXOC7 EXOC7 NCKAP1 NCKAP1 DYNLL2 DYNLL2 F7A3C5_ORNAN F7A3C5_ORNAN CYFIP1 CYFIP1 RAB9B RAB9B GAPDH GAPDH ARPC3 ARPC3 RELA RELA WASL WASL TRAF2 TRAF2 MYL9 MYL9 RAB5A RAB5A FOS FOS CYFIP2 CYFIP2 SNX33 SNX33 PFN2 PFN2 DYNLT1 DYNLT1 MYLPF MYLPF VPS41 VPS41 HSP90B1 HSP90B1 PLEKHM2 PLEKHM2 DYNC1H1 DYNC1H1 HSP90AA1 HSP90AA1 NCKAP1L NCKAP1L DYNC2LI1 DYNC2LI1 VPS33A VPS33A MAPK10 MAPK10 EXOC2 EXOC2 CSE1L CSE1L MYL7 MYL7 MYL5 MYL5 FYCO1 FYCO1 CTNNB1 CTNNB1 ELMO1 ELMO1 LOC103170567 LOC103170567 TXN TXN DYNLT3 DYNLT3 NFKBIA NFKBIA TXN2 TXN2 PKN1 PKN1 PFN4 PFN4 PIK3C2A PIK3C2A ACTB ACTB ARPC1A ARPC1A ARPC1B ARPC1B MAP2K3 MAP2K3 MYC MYC LOC100092114 LOC100092114 DYNC1I2 DYNC1I2 RHOB RHOB MAP3K7 MAP3K7 WASF3 WASF3 LOC100077443 LOC100077443 RHOH RHOH TNFSF10 TNFSF10 MAP2K2 MAP2K2 MAPK13 MAPK13 DYNC1LI1 DYNC1LI1 MAPK9 MAPK9 F6YTT1_ORNAN F6YTT1_ORNAN AKT3 AKT3 CDC42 CDC42 VPS39 VPS39 F6RKH7_ORNAN F6RKH7_ORNAN DYNC2H1 DYNC2H1 LOC100077243 LOC100077243 IL1B IL1B PLEKHM1 PLEKHM1 NOD1 NOD1 FLNA FLNA TCF7 TCF7 EXOC4 EXOC4 TRAF6 TRAF6 EXOC5 EXOC5 LOC100093050 LOC100093050 ARPC4 ARPC4 MAPK8 MAPK8 ANXA2 ANXA2 AHNAK AHNAK RAB7B RAB7B F7A0Z1_ORNAN F7A0Z1_ORNAN TLR4 TLR4 ARPC5L ARPC5L RIPK2 RIPK2 CYTH4 CYTH4 KPNA4 KPNA4 RHOA RHOA FLNB FLNB PIK3CA PIK3CA ARF6 ARF6 IL18 IL18 PTPRC PTPRC VPS16 VPS16 PIK3CB PIK3CB RIPK1 RIPK1 DYNC1I1 DYNC1I1 KPNA3 KPNA3 DYNLL1 DYNLL1 DYNC1LI2 DYNC1LI2 F7CC60_ORNAN F7CC60_ORNAN RAF1-2 RAF1-2 RHOJ RHOJ SNX9 SNX9 F6SPD0_ORNAN F6SPD0_ORNAN TAB1 TAB1 AHNAK2 AHNAK2 NFKB1 NFKB1 IL6 IL6 K7E737_ORNAN K7E737_ORNAN GCC2 GCC2 RPS3 RPS3 CYTH2 CYTH2 MAPK1 MAPK1 K7EDR7_ORNAN K7EDR7_ORNAN PODXL PODXL AKT1 AKT1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CASP3Caspase 3; Belongs to the peptidase C14A family. (285 aa)
VPS11Uncharacterized protein. (326 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (757 aa)
KLC1Uncharacterized protein. (639 aa)
LOC100088508Uncharacterized protein. (191 aa)
MYO6Myosin VI; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1293 aa)
ARPC5Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (154 aa)
VPS18Pep3_Vps18 domain-containing protein. (491 aa)
SKP1Skp1_POZ domain-containing protein; Belongs to the SKP1 family. (112 aa)
MYD88MYD88 innate immune signal transduction adaptor. (194 aa)
PYCARDPYD and CARD domain containing. (191 aa)
M6PRUncharacterized protein. (214 aa)
CASP7Uncharacterized protein; Belongs to the peptidase C14A family. (302 aa)
TCF7L2Transcription factor 7 like 2. (388 aa)
MAPK14Protein kinase domain-containing protein. (126 aa)
IRAK4Protein kinase domain-containing protein. (284 aa)
PAK3Non-specific serine/threonine protein kinase. (557 aa)
CHUKProtein kinase domain-containing protein. (719 aa)
RAB9ARAB9A, member RAS oncogene family. (201 aa)
ROCK2Uncharacterized protein; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1285 aa)
RAC1Rac family small GTPase 1. (192 aa)
CYTH3Cytohesin 3. (397 aa)
PIK3C3Phosphatidylinositol 3-kinase catalytic subunit type 3. (811 aa)
CYTH1Cytohesin 1. (231 aa)
EXOC7Exocyst complex component 7; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. (236 aa)
NCKAP1NCK associated protein 1. (1028 aa)
DYNLL2Dynein light chain. (89 aa)
F7A3C5_ORNANUncharacterized protein; Belongs to the peptidase C14A family. (487 aa)
CYFIP1Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1274 aa)
RAB9BRAB9B, member RAS oncogene family. (201 aa)
GAPDHGp_dh_C domain-containing protein. (161 aa)
ARPC3Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (178 aa)
RELARHD domain-containing protein. (159 aa)
WASLWASP like actin nucleation promoting factor. (474 aa)
TRAF2RING-type domain-containing protein. (258 aa)
MYL9Myosin light chain 9. (193 aa)
RAB5ARAB5A, member RAS oncogene family. (219 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (336 aa)
CYFIP2Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1286 aa)
SNX33BAR_3_WASP_bdg domain-containing protein. (73 aa)
PFN2Profilin; Belongs to the profilin family. (140 aa)
DYNLT1Dynein light chain Tctex-type 1. (113 aa)
MYLPFMyosin light chain, phosphorylatable, fast skeletal muscle. (178 aa)
VPS41Vacuolar protein sorting-associated protein 41 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport pathways; Belongs to the VPS41 family. (855 aa)
HSP90B1Heat shock protein 90 beta family member 1. (739 aa)
PLEKHM2Pleckstrin homology and RUN domain containing M2. (1024 aa)
DYNC1H1Dynein cytoplasmic 1 heavy chain 1. (4648 aa)
HSP90AA1Heat shock protein 90 alpha family class A member 1. (733 aa)
NCKAP1LUncharacterized protein. (473 aa)
DYNC2LI1Dynein cytoplasmic 2 light intermediate chain 1. (341 aa)
VPS33AUncharacterized protein; Belongs to the STXBP/unc-18/SEC1 family. (577 aa)
MAPK10Mitogen-activated protein kinase. (408 aa)
EXOC2Exocyst complex component 2; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. Belongs to the SEC5 family. (923 aa)
CSE1LChromosome segregation 1 like. (972 aa)
MYL7Myosin light chain 7. (174 aa)
MYL5Myosin light chain 5. (178 aa)
FYCO1FYVE and coiled-coil domain containing 1. (1545 aa)
CTNNB1Catenin beta 1. (781 aa)
ELMO1ELMO domain-containing protein. (215 aa)
LOC103170567Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (102 aa)
TXNThioredoxin; Belongs to the thioredoxin family. (105 aa)
DYNLT3Dynein light chain Tctex-type 3. (122 aa)
NFKBIAANK_REP_REGION domain-containing protein. (329 aa)
TXN2Thioredoxin 2. (168 aa)
PKN1Uncharacterized protein. (504 aa)
PFN4Profilin; Belongs to the profilin family. (129 aa)
PIK3C2APhosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha; Belongs to the PI3/PI4-kinase family. (1698 aa)
ACTBActin beta. (375 aa)
ARPC1AActin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (370 aa)
ARPC1BActin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (368 aa)
MAP2K3Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (347 aa)
MYCBHLH domain-containing protein. (182 aa)
LOC100092114Uncharacterized protein. (178 aa)
DYNC1I2Dynein cytoplasmic 1 intermediate chain 2. (630 aa)
RHOBRas homolog family member B. (196 aa)
MAP3K7Protein kinase domain-containing protein. (506 aa)
WASF3WASP family member 3. (501 aa)
LOC100077443Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
RHOHRas homolog family member H. (191 aa)
TNFSF10Tumor necrosis factor ligand superfamily member. (299 aa)
MAP2K2Protein kinase domain-containing protein. (252 aa)
MAPK13Mitogen-activated protein kinase. (376 aa)
DYNC1LI1Dynein light intermediate chain; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. (437 aa)
MAPK9Mitogen-activated protein kinase. (429 aa)
F6YTT1_ORNANUncharacterized protein; Belongs to the small GTPase superfamily. Arf family. (184 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (477 aa)
CDC42Cell division cycle 42. (183 aa)
VPS39VPS39 subunit of HOPS complex. (833 aa)
F6RKH7_ORNANUncharacterized protein; Belongs to the peptidase C14A family. (390 aa)
DYNC2H1Uncharacterized protein. (4302 aa)
LOC100077243Uncharacterized protein. (607 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (290 aa)
PLEKHM1DUF4206 domain-containing protein. (104 aa)
NOD1Nucleotide binding oligomerization domain containing 1. (958 aa)
FLNAUncharacterized protein. (2640 aa)
TCF7HMG box domain-containing protein. (173 aa)
EXOC4Sec8_exocyst domain-containing protein. (519 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (544 aa)
EXOC5Exocyst complex component 5. (708 aa)
LOC100093050Uncharacterized protein; Belongs to the small GTPase superfamily. Arf family. (175 aa)
ARPC4Actin-related protein 2/3 complex subunit 4; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament; Belongs to the ARPC4 family. (168 aa)
MAPK8Protein kinase domain-containing protein. (338 aa)
ANXA2Annexin. (339 aa)
AHNAKPDZ domain-containing protein. (514 aa)
RAB7BRAB7B, member RAS oncogene family. (200 aa)
F7A0Z1_ORNANUncharacterized protein; Belongs to the glycosyltransferase 29 family. (311 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (813 aa)
ARPC5LActin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (101 aa)
RIPK2CARD domain-containing protein. (334 aa)
CYTH4SEC7 domain-containing protein. (248 aa)
KPNA4Uncharacterized protein. (224 aa)
RHOAUncharacterized protein. (201 aa)
FLNBUncharacterized protein. (2410 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1069 aa)
ARF6ADP ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family. (175 aa)
IL18Uncharacterized protein. (202 aa)
PTPRCUncharacterized protein. (548 aa)
VPS16Vps16_N domain-containing protein. (196 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1034 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (612 aa)
DYNC1I1Uncharacterized protein. (133 aa)
KPNA3Importin subunit alpha; Functions in nuclear protein import. (525 aa)
DYNLL1Dynein light chain. (89 aa)
DYNC1LI2Dynein light intermediate chain; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. (101 aa)
F7CC60_ORNANRobl_LC7 domain-containing protein. (90 aa)
RAF1-2Protein kinase domain-containing protein. (141 aa)
RHOJUncharacterized protein. (128 aa)
SNX9BAR_3_WASP_bdg domain-containing protein. (157 aa)
F6SPD0_ORNANRobl_LC7 domain-containing protein. (117 aa)
TAB1PPM-type phosphatase domain-containing protein. (148 aa)
AHNAK2PDZ domain-containing protein. (106 aa)
NFKB1RHD domain-containing protein. (267 aa)
IL6Uncharacterized protein. (154 aa)
K7E737_ORNANProtein kinase domain-containing protein. (280 aa)
GCC2ADF-H domain-containing protein. (133 aa)
RPS3KH type-2 domain-containing protein. (143 aa)
CYTH2SEC7 domain-containing protein. (118 aa)
MAPK1Protein kinase domain-containing protein. (150 aa)
K7EDR7_ORNANUncharacterized protein; Belongs to the small GTPase superfamily. Arf family. (157 aa)
PODXLUncharacterized protein. (421 aa)
AKT1Uncharacterized protein. (230 aa)
Your Current Organism:
Ornithorhynchus anatinus
NCBI taxonomy Id: 9258
Other names: O. anatinus, Platypus anatinus, duck-billed platypus, duckbill platypus, platypus
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