(75 nodes) Measles network (Ornithorhynchus anatinus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CASP3	Caspase 3; Belongs to the peptidase C14A family. (285 aa)
	IKBKB	Inhibitor of nuclear factor kappa B kinase subunit beta. (757 aa)
	FASLG	Fas ligand; Belongs to the tumor necrosis factor family. (267 aa)
	MYD88	MYD88 innate immune signal transduction adaptor. (194 aa)
	PIK3R2	Uncharacterized protein. (724 aa)
	GSK3B	Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (247 aa)
	IRAK4	Protein kinase domain-containing protein. (284 aa)
	CCNE2	Cyclin E2; Belongs to the cyclin family. (405 aa)
	IFNAR2	Uncharacterized protein. (314 aa)
	IFNAR1	Uncharacterized protein. (579 aa)
	CHUK	Protein kinase domain-containing protein. (719 aa)
	RACK1	Receptor for activated C kinase 1. (317 aa)
	RAB9A	RAB9A, member RAS oncogene family. (201 aa)
	TLR7	Toll like receptor 7; Belongs to the Toll-like receptor family. (1124 aa)
	EIF2AK1	Protein kinase domain-containing protein. (479 aa)
	EIF2AK2	Uncharacterized protein. (552 aa)
	F7A3C5_ORNAN	Uncharacterized protein; Belongs to the peptidase C14A family. (487 aa)
	RAB9B	RAB9B, member RAS oncogene family. (201 aa)
	PIK3R1	SH2 domain-containing protein. (230 aa)
	RELA	RHD domain-containing protein. (159 aa)
	FOS	Fos proto-oncogene, AP-1 transcription factor subunit. (336 aa)
	CD28	IGv domain-containing protein. (178 aa)
	CD3G	CD3g molecule. (177 aa)
	F6X8T6_ORNAN	Uncharacterized protein. (163 aa)
	F6UIZ9_ORNAN	Uncharacterized protein; Belongs to the heat shock protein 70 family. (645 aa)
	F6Q149_ORNAN	Ig-like domain-containing protein. (117 aa)
	APAF1	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1250 aa)
	PIK3R3	Uncharacterized protein. (462 aa)
	IFIH1	Interferon induced with helicase C domain 1. (949 aa)
	MAPK10	Mitogen-activated protein kinase. (408 aa)
	F6VNP1_ORNAN	Uncharacterized protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (709 aa)
	LOC100080278	Uncharacterized protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (656 aa)
	RCHY1	Ring finger and CHY zinc finger domain containing 1. (229 aa)
	NFKBIA	ANK_REP_REGION domain-containing protein. (329 aa)
	CBLB	Cbl proto-oncogene B. (985 aa)
	EIF2AK4	Eukaryotic translation initiation factor 2 alpha kinase 4. (1621 aa)
	MAP3K7	Protein kinase domain-containing protein. (506 aa)
	LOC100077443	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
	HSPA2	Heat shock protein family A (Hsp70) member 2; Belongs to the heat shock protein 70 family. (635 aa)
	TBK1	TANK binding kinase 1. (700 aa)
	IRF7	IRF-3 domain-containing protein. (125 aa)
	MAPK9	Mitogen-activated protein kinase. (429 aa)
	AKT3	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (477 aa)
	EIF2AK3	Eukaryotic translation initiation factor 2 alpha kinase 3. (1028 aa)
	IL1B	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (290 aa)
	BID	Uncharacterized protein. (138 aa)
	TRAF6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (544 aa)
	TP53	P53 domain-containing protein. (87 aa)
	MAPK8	Protein kinase domain-containing protein. (338 aa)
	CSNK2A2	Casein kinase 2 alpha 2; Belongs to the protein kinase superfamily. (350 aa)
	CDK6	Cyclin dependent kinase 6. (203 aa)
	DDX58	DExD/H-box helicase 58. (783 aa)
	IL12B	Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (339 aa)
	STAT2	SH2 domain-containing protein. (361 aa)
	F7A0Z1_ORNAN	Uncharacterized protein; Belongs to the glycosyltransferase 29 family. (311 aa)
	TLR4	Toll like receptor 4; Belongs to the Toll-like receptor family. (813 aa)
	IL2RB	Fibronectin type-III domain-containing protein. (542 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1069 aa)
	HSPA8	Heat shock protein family A (Hsp70) member 8; Belongs to the heat shock protein 70 family. (586 aa)
	TRAF3	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (566 aa)
	CCND2	Uncharacterized protein; Belongs to the cyclin family. (227 aa)
	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1034 aa)
	TNFAIP3	TNF alpha induced protein 3. (824 aa)
	CCND3	Cyclin_C domain-containing protein. (170 aa)
	F6QIS3_ORNAN	SLAM domain-containing protein. (204 aa)
	JAK1	Protein kinase domain-containing protein. (107 aa)
	EIF2S1	Eukaryotic translation initiation factor 2 subunit alpha. (315 aa)
	NFKB1	RHD domain-containing protein. (267 aa)
	IL6	Uncharacterized protein. (154 aa)
	K7E878_ORNAN	CARD_2 domain-containing protein. (541 aa)
	STAT3	STAT_alpha domain-containing protein. (156 aa)
	ADAR	A to I editase domain-containing protein. (192 aa)
	FAS	Death domain-containing protein. (114 aa)
	AKT1	Uncharacterized protein. (230 aa)
	TYK2	Protein kinase domain-containing protein. (228 aa)

Your Current Organism:

Ornithorhynchus anatinus

NCBI taxonomy Id: 9258
Other names: O. anatinus, Platypus anatinus, duck-billed platypus, duckbill platypus, platypus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADAR	DDX58	ENSOANP00000030426	ENSOANP00000019214	A to I editase domain-containing protein.	DExD/H-box helicase 58.	0.413
ADAR	EIF2AK2	ENSOANP00000030426	ENSOANP00000006229	A to I editase domain-containing protein.	Uncharacterized protein.	0.633
ADAR	GSK3B	ENSOANP00000030426	ENSOANP00000002674	A to I editase domain-containing protein.	Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily.	0.408
ADAR	IFIH1	ENSOANP00000030426	ENSOANP00000009902	A to I editase domain-containing protein.	Interferon induced with helicase C domain 1.	0.589
AKT1	AKT3	ENSOANP00000033007	ENSOANP00000016278	Uncharacterized protein.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.900
AKT1	CASP3	ENSOANP00000033007	ENSOANP00000000517	Uncharacterized protein.	Caspase 3; Belongs to the peptidase C14A family.	0.453
AKT1	CHUK	ENSOANP00000033007	ENSOANP00000003934	Uncharacterized protein.	Protein kinase domain-containing protein.	0.960
AKT1	GSK3B	ENSOANP00000033007	ENSOANP00000002674	Uncharacterized protein.	Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily.	0.957
AKT1	IKBKB	ENSOANP00000033007	ENSOANP00000001111	Uncharacterized protein.	Inhibitor of nuclear factor kappa B kinase subunit beta.	0.958
AKT1	PIK3CA	ENSOANP00000033007	ENSOANP00000021943	Uncharacterized protein.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.963
AKT1	PIK3CB	ENSOANP00000033007	ENSOANP00000023160	Uncharacterized protein.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.949
AKT1	PIK3R1	ENSOANP00000033007	ENSOANP00000007081	Uncharacterized protein.	SH2 domain-containing protein.	0.955
AKT1	PIK3R2	ENSOANP00000033007	ENSOANP00000002083	Uncharacterized protein.	Uncharacterized protein.	0.942
AKT1	PIK3R3	ENSOANP00000033007	ENSOANP00000009424	Uncharacterized protein.	Uncharacterized protein.	0.949
AKT1	RELA	ENSOANP00000033007	ENSOANP00000007630	Uncharacterized protein.	RHD domain-containing protein.	0.465
AKT1	TBK1	ENSOANP00000033007	ENSOANP00000015719	Uncharacterized protein.	TANK binding kinase 1.	0.476
AKT1	TP53	ENSOANP00000033007	ENSOANP00000018980	Uncharacterized protein.	P53 domain-containing protein.	0.930
AKT1	TRAF6	ENSOANP00000033007	ENSOANP00000018657	Uncharacterized protein.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.526
AKT3	AKT1	ENSOANP00000016278	ENSOANP00000033007	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.900
AKT3	CASP3	ENSOANP00000016278	ENSOANP00000000517	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Caspase 3; Belongs to the peptidase C14A family.	0.453