(89 nodes) Influenza A network (Ornithorhynchus anatinus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CASP3	Caspase 3; Belongs to the peptidase C14A family. (285 aa)
	IKBKB	Inhibitor of nuclear factor kappa B kinase subunit beta. (757 aa)
	FASLG	Fas ligand; Belongs to the tumor necrosis factor family. (267 aa)
	MYD88	MYD88 innate immune signal transduction adaptor. (194 aa)
	PIK3R2	Uncharacterized protein. (724 aa)
	PYCARD	PYD and CARD domain containing. (191 aa)
	IRAK4	Protein kinase domain-containing protein. (284 aa)
	RAB11A	RAB11A, member RAS oncogene family. (226 aa)
	TMPRSS4	Transmembrane serine protease 4; Belongs to the peptidase S1 family. (440 aa)
	IFNAR2	Uncharacterized protein. (314 aa)
	IFNAR1	Uncharacterized protein. (579 aa)
	CHUK	Protein kinase domain-containing protein. (719 aa)
	TLR7	Toll like receptor 7; Belongs to the Toll-like receptor family. (1124 aa)
	RSAD2	Radical S-adenosyl methionine domain containing 2. (365 aa)
	KPNA6	Importin subunit alpha; Functions in nuclear protein import. (543 aa)
	EIF2AK2	Uncharacterized protein. (552 aa)
	F7A3C5_ORNAN	Uncharacterized protein; Belongs to the peptidase C14A family. (487 aa)
	PIK3R1	SH2 domain-containing protein. (230 aa)
	RELA	RHD domain-containing protein. (159 aa)
	TLR3	TIR domain-containing protein; Belongs to the Toll-like receptor family. (771 aa)
	NUP98	Peptidase S59 domain-containing protein. (1454 aa)
	IFNGR1	Uncharacterized protein. (460 aa)
	APAF1	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1250 aa)
	PIK3R3	Uncharacterized protein. (462 aa)
	IFNG	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (167 aa)
	IFIH1	Interferon induced with helicase C domain 1. (949 aa)
	F6VNP1_ORNAN	Uncharacterized protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (709 aa)
	LOC100080278	Uncharacterized protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (656 aa)
	TMPRSS2	Transmembrane serine protease 2; Belongs to the peptidase S1 family. (490 aa)
	LOC103170567	Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (102 aa)
	F7EHS9_ORNAN	C-X-C motif chemokine. (105 aa)
	NFKBIA	ANK_REP_REGION domain-containing protein. (329 aa)
	ACTB	Actin beta. (375 aa)
	CPSF4	Cleavage and polyadenylation specific factor 4. (234 aa)
	KPNA2	Importin subunit alpha; Functions in nuclear protein import. (529 aa)
	PRKCA	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (597 aa)
	LOC100086459	Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (247 aa)
	LOC100088455	Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (246 aa)
	PML	Uncharacterized protein. (331 aa)
	F7G885_ORNAN	Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (278 aa)
	F7F1H7_ORNAN	Ig-like domain-containing protein. (150 aa)
	LOC100077443	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
	BCL2L2	BCL2 like 2. (244 aa)
	RAE1	Ribonucleic acid export 1. (368 aa)
	TNFSF10	Tumor necrosis factor ligand superfamily member. (299 aa)
	MAP2K2	Protein kinase domain-containing protein. (252 aa)
	TBK1	TANK binding kinase 1. (700 aa)
	IRF7	IRF-3 domain-containing protein. (125 aa)
	JAK2	Tyrosine-protein kinase. (948 aa)
	AKT3	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (477 aa)
	F6RKH7_ORNAN	Uncharacterized protein; Belongs to the peptidase C14A family. (390 aa)
	IL1B	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (290 aa)
	F6XSU3_ORNAN	Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (250 aa)
	BID	Uncharacterized protein. (138 aa)
	NXT2	Nuclear transport factor 2 like export factor 2. (151 aa)
	CDK6	Cyclin dependent kinase 6. (203 aa)
	DDX58	DExD/H-box helicase 58. (783 aa)
	IL12B	Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (339 aa)
	XPO1	Exportin 1. (1032 aa)
	KPNA5	Importin subunit alpha; Functions in nuclear protein import. (536 aa)
	STAT2	SH2 domain-containing protein. (361 aa)
	DNAJB1	DnaJ heat shock protein family (Hsp40) member B1. (341 aa)
	SLC25A5	Solute carrier family 25 member 5; Belongs to the mitochondrial carrier (TC 2.A.29) family. (252 aa)
	F7A0Z1_ORNAN	Uncharacterized protein; Belongs to the glycosyltransferase 29 family. (311 aa)
	TLR4	Toll like receptor 4; Belongs to the Toll-like receptor family. (813 aa)
	VDAC1	Voltage dependent anion channel 1. (269 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1069 aa)
	TMPRSS11D	Transmembrane serine protease 11D; Belongs to the peptidase S1 family. (423 aa)
	IL18	Uncharacterized protein. (202 aa)
	TRAF3	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (566 aa)
	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1034 aa)
	DNAJC3	Uncharacterized protein. (462 aa)
	CCND3	Cyclin_C domain-containing protein. (170 aa)
	HLA-DRA	MHC class II DR alpha precursor; Belongs to the MHC class II family. (254 aa)
	RAF1-2	Protein kinase domain-containing protein. (141 aa)
	JAK1	Protein kinase domain-containing protein. (107 aa)
	F7EB27_ORNAN	IGc1 domain-containing protein. (90 aa)
	F6YCI2_ORNAN	Uncharacterized protein. (135 aa)
	F6SXK4_ORNAN	Uncharacterized protein. (165 aa)
	EP300	E1A binding protein p300. (2421 aa)
	EIF2S1	Eukaryotic translation initiation factor 2 subunit alpha. (315 aa)
	NFKB1	RHD domain-containing protein. (267 aa)
	IL6	Uncharacterized protein. (154 aa)
	K7E878_ORNAN	CARD_2 domain-containing protein. (541 aa)
	ADAR	A to I editase domain-containing protein. (192 aa)
	MAPK1	Protein kinase domain-containing protein. (150 aa)
	FAS	Death domain-containing protein. (114 aa)
	AKT1	Uncharacterized protein. (230 aa)
	TYK2	Protein kinase domain-containing protein. (228 aa)

Your Current Organism:

Ornithorhynchus anatinus

NCBI taxonomy Id: 9258
Other names: O. anatinus, Platypus anatinus, duck-billed platypus, duckbill platypus, platypus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACTB	CASP3	ENSOANP00000012287	ENSOANP00000000517	Actin beta.	Caspase 3; Belongs to the peptidase C14A family.	0.914
ADAR	DDX58	ENSOANP00000030426	ENSOANP00000019214	A to I editase domain-containing protein.	DExD/H-box helicase 58.	0.413
ADAR	EIF2AK2	ENSOANP00000030426	ENSOANP00000006229	A to I editase domain-containing protein.	Uncharacterized protein.	0.633
ADAR	IFIH1	ENSOANP00000030426	ENSOANP00000009902	A to I editase domain-containing protein.	Interferon induced with helicase C domain 1.	0.589
AKT1	AKT3	ENSOANP00000033007	ENSOANP00000016278	Uncharacterized protein.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.900
AKT1	CASP3	ENSOANP00000033007	ENSOANP00000000517	Uncharacterized protein.	Caspase 3; Belongs to the peptidase C14A family.	0.453
AKT1	CHUK	ENSOANP00000033007	ENSOANP00000003934	Uncharacterized protein.	Protein kinase domain-containing protein.	0.960
AKT1	IKBKB	ENSOANP00000033007	ENSOANP00000001111	Uncharacterized protein.	Inhibitor of nuclear factor kappa B kinase subunit beta.	0.958
AKT1	MAPK1	ENSOANP00000033007	ENSOANP00000030955	Uncharacterized protein.	Protein kinase domain-containing protein.	0.927
AKT1	PIK3CA	ENSOANP00000033007	ENSOANP00000021943	Uncharacterized protein.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.963
AKT1	PIK3CB	ENSOANP00000033007	ENSOANP00000023160	Uncharacterized protein.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.949
AKT1	PIK3R1	ENSOANP00000033007	ENSOANP00000007081	Uncharacterized protein.	SH2 domain-containing protein.	0.955
AKT1	PIK3R2	ENSOANP00000033007	ENSOANP00000002083	Uncharacterized protein.	Uncharacterized protein.	0.942
AKT1	PIK3R3	ENSOANP00000033007	ENSOANP00000009424	Uncharacterized protein.	Uncharacterized protein.	0.949
AKT1	RAF1-2	ENSOANP00000033007	ENSOANP00000025744	Uncharacterized protein.	Protein kinase domain-containing protein.	0.944
AKT1	RELA	ENSOANP00000033007	ENSOANP00000007630	Uncharacterized protein.	RHD domain-containing protein.	0.465
AKT1	TBK1	ENSOANP00000033007	ENSOANP00000015719	Uncharacterized protein.	TANK binding kinase 1.	0.476
AKT3	AKT1	ENSOANP00000016278	ENSOANP00000033007	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.900
AKT3	CASP3	ENSOANP00000016278	ENSOANP00000000517	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Caspase 3; Belongs to the peptidase C14A family.	0.453
AKT3	CHUK	ENSOANP00000016278	ENSOANP00000003934	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Protein kinase domain-containing protein.	0.960