STRINGSTRING
LOC100093337 LOC100093337 LOC100093154 LOC100093154 F6QTT1_ORNAN F6QTT1_ORNAN F6PXG4_ORNAN F6PXG4_ORNAN F7CNH7_ORNAN F7CNH7_ORNAN CASP3 CASP3 POLB POLB VDAC3 VDAC3 GTF2A1 GTF2A1 SND1 SND1 GSN GSN VAC14 VAC14 PIK3R2 PIK3R2 F7GBN2_ORNAN F7GBN2_ORNAN F7F763_ORNAN F7F763_ORNAN UBR4 UBR4 CCNE2 CCNE2 F6STU0_ORNAN F6STU0_ORNAN YWHAE YWHAE HDAC8 HDAC8 F6ZP19_ORNAN F6ZP19_ORNAN RAC1 RAC1 YWHAH YWHAH HDAC2 HDAC2 ACTN1 ACTN1 EIF2AK2 EIF2AK2 ACTN4 ACTN4 F7A3C5_ORNAN F7A3C5_ORNAN YWHAQ YWHAQ PSMC1 PSMC1 MAD1L1 MAD1L1 CDK1 CDK1 PIK3R1 PIK3R1 RELA RELA DDB1 DDB1 TRAF2 TRAF2 KAT2B KAT2B CREB3L2 CREB3L2 LOC100078585 LOC100078585 LYN LYN ATP6V0D2 ATP6V0D2 F7CJV3_ORNAN F7CJV3_ORNAN PIK3R3 PIK3R3 MDM2 MDM2 C3 C3 H2BE1 H2BE1 NFKB2 NFKB2 PRKACA PRKACA CHEK1 CHEK1 PXN PXN RBPJ RBPJ F6X8B2_ORNAN F6X8B2_ORNAN CCR3 CCR3 UBE3A UBE3A F6W417_ORNAN F6W417_ORNAN NFKBIA NFKBIA YWHAZ YWHAZ MAPKAPK2 MAPKAPK2 USP7 USP7 TRAF5 TRAF5 ATF2 ATF2 DLG1 DLG1 CREB5 CREB5 HDAC9 HDAC9 F6TQV0_ORNAN F6TQV0_ORNAN CREB1 CREB1 IRF7 IRF7 LOC100083732 LOC100083732 CDC42 CDC42 GTF2B GTF2B SNW1 SNW1 DDX3X DDX3X TP53 TP53 CDK6 CDK6 CCR4 CCR4 F7FNX2_ORNAN F7FNX2_ORNAN REL REL HDAC11 HDAC11 TBP TBP HDAC4 HDAC4 TBPL1 TBPL1 CREB3L3 CREB3L3 RBL2 RBL2 GTF2A2 GTF2A2 RHOA RHOA PIK3CA PIK3CA LOC100080175 LOC100080175 PRKACB PRKACB LOC114813777 LOC114813777 RANBP1 RANBP1 HNRNPK HNRNPK TRAF3 TRAF3 CCND2 CCND2 PIK3CB PIK3CB GTF2H1 GTF2H1 CCNA2 CCNA2 GTF2H3 GTF2H3 CCND3 CCND3 RB1 RB1 PKM PKM F7FXJ1_ORNAN F7FXJ1_ORNAN YWHAB YWHAB GTF2E2 GTF2E2 GTF2H2 GTF2H2 JAK1 JAK1 F6XEC2_ORNAN F6XEC2_ORNAN EP300 EP300 LOC100086501 LOC100086501 NFKB1 NFKB1 IL6ST IL6ST TBPL2 TBPL2 YWHAG YWHAG SCRIB SCRIB HDAC6 HDAC6 HDAC10 HDAC10 STAT3 STAT3 RBL1 RBL1 TRAF1-2 TRAF1-2 MAPK1 MAPK1 RASA2 RASA2 HDAC1-2 HDAC1-2 DNAJA3 DNAJA3
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC100093337Histone H2B; Belongs to the histone H2B family. (135 aa)
LOC100093154Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
F6QTT1_ORNANHistone H2B; Belongs to the histone H2B family. (136 aa)
F6PXG4_ORNANHistone H2B; Belongs to the histone H2B family. (136 aa)
F7CNH7_ORNANHistone H2B; Belongs to the histone H2B family. (135 aa)
CASP3Caspase 3; Belongs to the peptidase C14A family. (285 aa)
POLBDNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (224 aa)
VDAC3Voltage dependent anion channel 3. (284 aa)
GTF2A1General transcription factor IIA subunit 1. (377 aa)
SND1Staphylococcal nuclease domain-containing protein; Endonuclease that mediates miRNA decay of both protein-free and AGO2-loaded miRNAs. (909 aa)
GSNUncharacterized protein. (413 aa)
VAC14VAC14 component of PIKFYVE complex. (704 aa)
PIK3R2Uncharacterized protein. (724 aa)
F7GBN2_ORNANIg-like domain-containing protein; Belongs to the MHC class I family. (311 aa)
F7F763_ORNANMHC_I-like_Ag-recog domain-containing protein; Belongs to the MHC class I family. (199 aa)
UBR4Uncharacterized protein. (746 aa)
CCNE2Cyclin E2; Belongs to the cyclin family. (405 aa)
F6STU0_ORNANANK_REP_REGION domain-containing protein. (106 aa)
YWHAETyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon; Belongs to the 14-3-3 family. (233 aa)
HDAC8Histone deacetylase 8; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (515 aa)
F6ZP19_ORNANIg-like domain-containing protein; Belongs to the MHC class I family. (342 aa)
RAC1Rac family small GTPase 1. (192 aa)
YWHAHTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta; Belongs to the 14-3-3 family. (221 aa)
HDAC2Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (430 aa)
ACTN1Uncharacterized protein. (498 aa)
EIF2AK2Uncharacterized protein. (552 aa)
ACTN4EF-hand domain-containing protein. (99 aa)
F7A3C5_ORNANUncharacterized protein; Belongs to the peptidase C14A family. (487 aa)
YWHAQ14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (148 aa)
PSMC1Proteasome 26S subunit, ATPase 1; Belongs to the AAA ATPase family. (367 aa)
MAD1L1Mitotic arrest deficient 1 like 1. (544 aa)
CDK1Cyclin dependent kinase 1; Belongs to the protein kinase superfamily. (303 aa)
PIK3R1SH2 domain-containing protein. (230 aa)
RELARHD domain-containing protein. (159 aa)
DDB1Damage specific DNA binding protein 1. (1032 aa)
TRAF2RING-type domain-containing protein. (258 aa)
KAT2BLysine acetyltransferase 2B. (675 aa)
CREB3L2Uncharacterized protein. (177 aa)
LOC100078585Ig-like domain-containing protein; Belongs to the MHC class I family. (352 aa)
LYNTyrosine-protein kinase. (514 aa)
ATP6V0D2Uncharacterized protein. (199 aa)
F7CJV3_ORNANHTH TFE/IIEalpha-type domain-containing protein. (298 aa)
PIK3R3Uncharacterized protein. (462 aa)
MDM2MDM2 proto-oncogene. (438 aa)
C3Complement C3. (1656 aa)
H2BE1Histone H2B; Belongs to the histone H2B family. (127 aa)
NFKB2RHD domain-containing protein. (201 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha. (312 aa)
CHEK1Checkpoint kinase 1; Belongs to the protein kinase superfamily. (476 aa)
PXNPaxillin; Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Belongs to the paxillin family. (580 aa)
RBPJRecombination signal binding protein for immunoglobulin kappa J region. (494 aa)
F6X8B2_ORNANG_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (365 aa)
CCR3C-C motif chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family. (362 aa)
UBE3AHECT domain-containing protein. (599 aa)
F6W417_ORNANIg-like domain-containing protein; Belongs to the MHC class I family. (249 aa)
NFKBIAANK_REP_REGION domain-containing protein. (329 aa)
YWHAZTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta; Belongs to the 14-3-3 family. (245 aa)
MAPKAPK2MAPK activated protein kinase 2. (330 aa)
USP7Ubiquitin specific peptidase 7; Belongs to the peptidase C19 family. (1055 aa)
TRAF5TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (560 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
DLG1Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (798 aa)
CREB5Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (499 aa)
HDAC9HDAC4_Gln domain-containing protein. (607 aa)
F6TQV0_ORNANHistone domain-containing protein; Belongs to the histone H2B family. (149 aa)
CREB1BZIP domain-containing protein. (47 aa)
IRF7IRF-3 domain-containing protein. (125 aa)
LOC100083732Histone domain-containing protein; Belongs to the histone H2B family. (131 aa)
CDC42Cell division cycle 42. (183 aa)
GTF2BGeneral transcription factor IIB. (275 aa)
SNW1SNW domain containing 1. (535 aa)
DDX3XUncharacterized protein; Belongs to the DEAD box helicase family. (665 aa)
TP53P53 domain-containing protein. (87 aa)
CDK6Cyclin dependent kinase 6. (203 aa)
CCR4C-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family. (364 aa)
F7FNX2_ORNANIg-like domain-containing protein; Belongs to the MHC class I family. (296 aa)
RELREL proto-oncogene, NF-kB subunit. (600 aa)
HDAC11Hist_deacetyl domain-containing protein. (163 aa)
TBPTATA-box binding protein. (328 aa)
HDAC4Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1079 aa)
TBPL1TATA-box binding protein like 1. (183 aa)
CREB3L3cAMP responsive element binding protein 3 like 3. (352 aa)
RBL2RB transcriptional corepressor like 2. (1003 aa)
GTF2A2Transcription initiation factor IIA subunit 2; TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation; Belongs to the TFIIA subunit 2 family. (109 aa)
RHOAUncharacterized protein. (201 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1069 aa)
LOC100080175Histone domain-containing protein; Belongs to the histone H2B family. (130 aa)
PRKACBUncharacterized protein. (243 aa)
LOC114813777Histone domain-containing protein; Belongs to the histone H2B family. (125 aa)
RANBP1RAN binding protein 1. (206 aa)
HNRNPKHeterogeneous nuclear ribonucleoprotein K. (464 aa)
TRAF3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (566 aa)
CCND2Uncharacterized protein; Belongs to the cyclin family. (227 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1034 aa)
GTF2H1Uncharacterized protein. (309 aa)
CCNA2Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (386 aa)
GTF2H3Uncharacterized protein. (312 aa)
CCND3Cyclin_C domain-containing protein. (170 aa)
RB1Uncharacterized protein. (725 aa)
PKMPyruvate kinase; Belongs to the pyruvate kinase family. (279 aa)
F7FXJ1_ORNANHistone domain-containing protein; Belongs to the histone H2B family. (122 aa)
YWHABTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta; Belongs to the 14-3-3 family. (294 aa)
GTF2E2General transcription factor IIE subunit 2. (236 aa)
GTF2H2General transcription factor IIH subunit. (395 aa)
JAK1Protein kinase domain-containing protein. (107 aa)
F6XEC2_ORNANUncharacterized protein. (137 aa)
EP300E1A binding protein p300. (2421 aa)
LOC100086501Ig-like domain-containing protein. (355 aa)
NFKB1RHD domain-containing protein. (267 aa)
IL6STInterleukin 6 signal transducer. (783 aa)
TBPL2Transcription initiation factor TFIID TATA-box-binding protein. (115 aa)
YWHAG14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (122 aa)
SCRIBUncharacterized protein. (228 aa)
HDAC6Uncharacterized protein. (235 aa)
HDAC10Hist_deacetyl domain-containing protein. (167 aa)
STAT3STAT_alpha domain-containing protein. (156 aa)
RBL1DUF3452 domain-containing protein. (163 aa)
TRAF1-2RING-type domain-containing protein. (115 aa)
MAPK1Protein kinase domain-containing protein. (150 aa)
RASA2PH domain-containing protein. (77 aa)
HDAC1-2Hist_deacetyl domain-containing protein. (200 aa)
DNAJA3J domain-containing protein. (150 aa)
Your Current Organism:
Ornithorhynchus anatinus
NCBI taxonomy Id: 9258
Other names: O. anatinus, Platypus anatinus, duck-billed platypus, duckbill platypus, platypus
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