STRINGSTRING
PIK3R2 PIK3R2 FGF10 FGF10 F6STU0_ORNAN F6STU0_ORNAN CDH1 CDH1 FGFR1 FGFR1 HGF HGF FGF5 FGF5 PDGFRA PDGFRA PIK3R1 PIK3R1 IGF1 IGF1 PIK3R3 PIK3R3 MDM2 MDM2 DDB2 DDB2 PDGFB PDGFB PDGFA PDGFA FGF4 FGF4 FGF19 FGF19 GADD45A GADD45A FGF9 FGF9 MAP2K2 MAP2K2 FGF7 FGF7 AKT3 AKT3 PDGFD PDGFD EGFR EGFR TP53 TP53 FGF22 FGF22 CDK6 CDK6 MITF MITF FGF18 FGF18 BRAF BRAF PIK3CA PIK3CA FGF1 FGF1 PIK3CB PIK3CB MET MET RB1 RB1 PDGFC PDGFC POLK POLK RAF1-2 RAF1-2 E2F2 E2F2 FGF6 FGF6 IGF1R IGF1R MAPK1 MAPK1 AKT1 AKT1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PIK3R2Uncharacterized protein. (724 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (99 aa)
F6STU0_ORNANANK_REP_REGION domain-containing protein. (106 aa)
CDH1Cadherin 1; Cadherins are calcium-dependent cell adhesion proteins. (783 aa)
FGFR1Fibroblast growth factor receptor. (821 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (706 aa)
FGF5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (152 aa)
PDGFRAUncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (872 aa)
PIK3R1SH2 domain-containing protein. (230 aa)
IGF1Insulin like growth factor 1. (153 aa)
PIK3R3Uncharacterized protein. (462 aa)
MDM2MDM2 proto-oncogene. (438 aa)
DDB2Damage specific DNA binding protein 2. (346 aa)
PDGFBPDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (212 aa)
PDGFAPlatelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (182 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (202 aa)
FGF19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (87 aa)
GADD45ARibosomal_L7Ae domain-containing protein. (321 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
MAP2K2Protein kinase domain-containing protein. (252 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (99 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (477 aa)
PDGFDPlatelet derived growth factor D. (340 aa)
EGFRReceptor protein-tyrosine kinase. (1215 aa)
TP53P53 domain-containing protein. (87 aa)
FGF22Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (96 aa)
CDK6Cyclin dependent kinase 6. (203 aa)
MITFBHLH domain-containing protein. (234 aa)
FGF18Uncharacterized protein; Belongs to the heparin-binding growth factors family. (98 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (702 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1069 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1034 aa)
METHepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] (982 aa)
RB1Uncharacterized protein. (725 aa)
PDGFCPlatelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (305 aa)
POLKDNA polymerase kappa. (876 aa)
RAF1-2Protein kinase domain-containing protein. (141 aa)
E2F2E2F_TDP domain-containing protein. (176 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (195 aa)
IGF1RRecep_L_domain domain-containing protein. (214 aa)
MAPK1Protein kinase domain-containing protein. (150 aa)
AKT1Uncharacterized protein. (230 aa)
Your Current Organism:
Ornithorhynchus anatinus
NCBI taxonomy Id: 9258
Other names: O. anatinus, Platypus anatinus, duck-billed platypus, duckbill platypus, platypus
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