(61 nodes) Small cell lung cancer network (Ornithorhynchus anatinus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CASP3	Caspase 3; Belongs to the peptidase C14A family. (285 aa)
	ITGA3	Uncharacterized protein. (416 aa)
	IKBKB	Inhibitor of nuclear factor kappa B kinase subunit beta. (757 aa)
	LAMC1	Laminin subunit gamma 1. (1473 aa)
	LAMC2	Laminin subunit gamma 2. (1078 aa)
	PTGS2	Prostaglandin-endoperoxide synthase 2. (604 aa)
	COL4A5	Collagen type IV alpha 5 chain. (1694 aa)
	PIK3R2	Uncharacterized protein. (724 aa)
	CCNE2	Cyclin E2; Belongs to the cyclin family. (405 aa)
	CHUK	Protein kinase domain-containing protein. (719 aa)
	LAMA3	Uncharacterized protein. (950 aa)
	RXRA	Retinoid X receptor alpha. (433 aa)
	PIK3R1	SH2 domain-containing protein. (230 aa)
	RELA	RHD domain-containing protein. (159 aa)
	TRAF2	RING-type domain-containing protein. (258 aa)
	APAF1	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1250 aa)
	NOS2	Nitric oxide synthase; Produces nitric oxide (NO). (1144 aa)
	MAX	MYC associated factor X. (160 aa)
	PIK3R3	Uncharacterized protein. (462 aa)
	ITGB1	Integrin beta; Belongs to the integrin beta chain family. (819 aa)
	DDB2	Damage specific DNA binding protein 2. (346 aa)
	LAMA2	Uncharacterized protein. (2236 aa)
	PTK2	Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1142 aa)
	LAMB3	Laminin N-terminal domain-containing protein. (110 aa)
	NFKBIA	ANK_REP_REGION domain-containing protein. (329 aa)
	GADD45A	Ribosomal_L7Ae domain-containing protein. (321 aa)
	MYC	BHLH domain-containing protein. (182 aa)
	TRAF5	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (560 aa)
	ITGA6	Integrin subunit alpha 6; Belongs to the integrin alpha chain family. (1091 aa)
	ZBTB17	Zinc finger and BTB domain containing 17. (911 aa)
	LOC100077443	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
	COL4A6	Collagen IV NC1 domain-containing protein. (363 aa)
	COL4A3	Collagen IV NC1 domain-containing protein. (496 aa)
	AKT3	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (477 aa)
	LOC100077243	Uncharacterized protein. (607 aa)
	ITGA2	Integrin_alpha2 domain-containing protein. (359 aa)
	COL4A4	Collagen type IV alpha 4 chain. (1595 aa)
	TRAF6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (544 aa)
	TP53	P53 domain-containing protein. (87 aa)
	CDK6	Cyclin dependent kinase 6. (203 aa)
	RARB	Retinoic acid receptor beta. (422 aa)
	FN1	Uncharacterized protein. (1001 aa)
	TRAF4	Uncharacterized protein. (278 aa)
	CKS1B	Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (62 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1069 aa)
	TRAF3	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (566 aa)
	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1034 aa)
	RB1	Uncharacterized protein. (725 aa)
	COL4A2	Collagen IV NC1 domain-containing protein. (1649 aa)
	ITGAV	Integrin_alpha2 domain-containing protein; Belongs to the integrin alpha chain family. (523 aa)
	POLK	DNA polymerase kappa. (876 aa)
	E2F2	E2F_TDP domain-containing protein. (176 aa)
	LAMB2-2	Laminin N-terminal domain-containing protein. (238 aa)
	NFKB1	RHD domain-containing protein. (267 aa)
	COL4A1	Collagen type IV alpha 1 chain. (1642 aa)
	BIRC7	Uncharacterized protein. (282 aa)
	TRAF1-2	RING-type domain-containing protein. (115 aa)
	LAMA4	LAM_G_DOMAIN domain-containing protein. (311 aa)
	LAMA1-2	Uncharacterized protein. (214 aa)
	AKT1	Uncharacterized protein. (230 aa)
	LAMA5-2	Uncharacterized protein. (107 aa)

Your Current Organism:

Ornithorhynchus anatinus

NCBI taxonomy Id: 9258
Other names: O. anatinus, Platypus anatinus, duck-billed platypus, duckbill platypus, platypus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKT1	AKT3	ENSOANP00000033007	ENSOANP00000016278	Uncharacterized protein.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.900
AKT1	CASP3	ENSOANP00000033007	ENSOANP00000000517	Uncharacterized protein.	Caspase 3; Belongs to the peptidase C14A family.	0.453
AKT1	CHUK	ENSOANP00000033007	ENSOANP00000003934	Uncharacterized protein.	Protein kinase domain-containing protein.	0.960
AKT1	IKBKB	ENSOANP00000033007	ENSOANP00000001111	Uncharacterized protein.	Inhibitor of nuclear factor kappa B kinase subunit beta.	0.958
AKT1	NOS2	ENSOANP00000033007	ENSOANP00000009010	Uncharacterized protein.	Nitric oxide synthase; Produces nitric oxide (NO).	0.934
AKT1	PIK3CA	ENSOANP00000033007	ENSOANP00000021943	Uncharacterized protein.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.963
AKT1	PIK3CB	ENSOANP00000033007	ENSOANP00000023160	Uncharacterized protein.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.949
AKT1	PIK3R1	ENSOANP00000033007	ENSOANP00000007081	Uncharacterized protein.	SH2 domain-containing protein.	0.955
AKT1	PIK3R2	ENSOANP00000033007	ENSOANP00000002083	Uncharacterized protein.	Uncharacterized protein.	0.942
AKT1	PIK3R3	ENSOANP00000033007	ENSOANP00000009424	Uncharacterized protein.	Uncharacterized protein.	0.949
AKT1	RELA	ENSOANP00000033007	ENSOANP00000007630	Uncharacterized protein.	RHD domain-containing protein.	0.465
AKT1	TP53	ENSOANP00000033007	ENSOANP00000018980	Uncharacterized protein.	P53 domain-containing protein.	0.930
AKT1	TRAF6	ENSOANP00000033007	ENSOANP00000018657	Uncharacterized protein.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.526
AKT3	AKT1	ENSOANP00000016278	ENSOANP00000033007	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.900
AKT3	CASP3	ENSOANP00000016278	ENSOANP00000000517	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Caspase 3; Belongs to the peptidase C14A family.	0.453
AKT3	CHUK	ENSOANP00000016278	ENSOANP00000003934	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Protein kinase domain-containing protein.	0.960
AKT3	IKBKB	ENSOANP00000016278	ENSOANP00000001111	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Inhibitor of nuclear factor kappa B kinase subunit beta.	0.958
AKT3	NOS2	ENSOANP00000016278	ENSOANP00000009010	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Nitric oxide synthase; Produces nitric oxide (NO).	0.934
AKT3	PIK3CA	ENSOANP00000016278	ENSOANP00000021943	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.946
AKT3	PIK3CB	ENSOANP00000016278	ENSOANP00000023160	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.949