(37 nodes) Non-small cell lung cancer network (Ornithorhynchus anatinus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	FOXO3	Fork-head domain-containing protein. (479 aa)
	PIK3R2	Uncharacterized protein. (724 aa)
	F6STU0_ORNAN	ANK_REP_REGION domain-containing protein. (106 aa)
	PDPK1	Protein kinase domain-containing protein. (280 aa)
	HGF	Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (706 aa)
	RXRA	Retinoid X receptor alpha. (433 aa)
	PIK3R1	SH2 domain-containing protein. (230 aa)
	RASSF1	Ras association domain family member 1. (239 aa)
	PIK3R3	Uncharacterized protein. (462 aa)
	DDB2	Damage specific DNA binding protein 2. (346 aa)
	GADD45A	Ribosomal_L7Ae domain-containing protein. (321 aa)
	PRKCA	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (597 aa)
	PRKCG	Uncharacterized protein. (304 aa)
	MAP2K2	Protein kinase domain-containing protein. (252 aa)
	AKT3	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (477 aa)
	EGFR	Receptor protein-tyrosine kinase. (1215 aa)
	TP53	P53 domain-containing protein. (87 aa)
	CDK6	Cyclin dependent kinase 6. (203 aa)
	RARB	Retinoic acid receptor beta. (422 aa)
	BRAF	B-Raf proto-oncogene, serine/threonine kinase. (702 aa)
	STK4	Protein kinase domain-containing protein. (284 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1069 aa)
	SOS2	SOS Ras/Rho guanine nucleotide exchange factor 2. (1333 aa)
	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1034 aa)
	SOS1	SOS Ras/Rac guanine nucleotide exchange factor 1. (1214 aa)
	MET	Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] (982 aa)
	RB1	Uncharacterized protein. (725 aa)
	POLK	DNA polymerase kappa. (876 aa)
	RAF1-2	Protein kinase domain-containing protein. (141 aa)
	E2F2	E2F_TDP domain-containing protein. (176 aa)
	PLCG1	Uncharacterized protein. (265 aa)
	RASSF5	Uncharacterized protein. (268 aa)
	PLCG2	SH2 domain-containing protein. (238 aa)
	STAT3	STAT_alpha domain-containing protein. (156 aa)
	MAPK1	Protein kinase domain-containing protein. (150 aa)
	EML4	Uncharacterized protein. (149 aa)
	AKT1	Uncharacterized protein. (230 aa)

Your Current Organism:

Ornithorhynchus anatinus

NCBI taxonomy Id: 9258
Other names: O. anatinus, Platypus anatinus, duck-billed platypus, duckbill platypus, platypus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKT1	AKT3	ENSOANP00000033007	ENSOANP00000016278	Uncharacterized protein.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.900
AKT1	EGFR	ENSOANP00000033007	ENSOANP00000016946	Uncharacterized protein.	Receptor protein-tyrosine kinase.	0.495
AKT1	FOXO3	ENSOANP00000033007	ENSOANP00000001191	Uncharacterized protein.	Fork-head domain-containing protein.	0.970
AKT1	MAPK1	ENSOANP00000033007	ENSOANP00000030955	Uncharacterized protein.	Protein kinase domain-containing protein.	0.927
AKT1	PDPK1	ENSOANP00000033007	ENSOANP00000003693	Uncharacterized protein.	Protein kinase domain-containing protein.	0.982
AKT1	PIK3CA	ENSOANP00000033007	ENSOANP00000021943	Uncharacterized protein.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.963
AKT1	PIK3CB	ENSOANP00000033007	ENSOANP00000023160	Uncharacterized protein.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.949
AKT1	PIK3R1	ENSOANP00000033007	ENSOANP00000007081	Uncharacterized protein.	SH2 domain-containing protein.	0.955
AKT1	PIK3R2	ENSOANP00000033007	ENSOANP00000002083	Uncharacterized protein.	Uncharacterized protein.	0.942
AKT1	PIK3R3	ENSOANP00000033007	ENSOANP00000009424	Uncharacterized protein.	Uncharacterized protein.	0.949
AKT1	RAF1-2	ENSOANP00000033007	ENSOANP00000025744	Uncharacterized protein.	Protein kinase domain-containing protein.	0.944
AKT1	TP53	ENSOANP00000033007	ENSOANP00000018980	Uncharacterized protein.	P53 domain-containing protein.	0.930
AKT3	AKT1	ENSOANP00000016278	ENSOANP00000033007	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.900
AKT3	FOXO3	ENSOANP00000016278	ENSOANP00000001191	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Fork-head domain-containing protein.	0.970
AKT3	MAPK1	ENSOANP00000016278	ENSOANP00000030955	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Protein kinase domain-containing protein.	0.927
AKT3	PDPK1	ENSOANP00000016278	ENSOANP00000003693	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Protein kinase domain-containing protein.	0.983
AKT3	PIK3CA	ENSOANP00000016278	ENSOANP00000021943	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.946
AKT3	PIK3CB	ENSOANP00000016278	ENSOANP00000023160	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.949
AKT3	PIK3R1	ENSOANP00000016278	ENSOANP00000007081	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	SH2 domain-containing protein.	0.945
AKT3	PIK3R2	ENSOANP00000016278	ENSOANP00000002083	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.961