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| | AKF03052.1 | Transaldolase. (371 aa) |
| | metK | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (423 aa) |
| | trpB | Tryptophan synthase beta chain like protein; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (467 aa) |
| | AKF03439.1 | Ribose-phosphate pyrophosphokinase; Belongs to the ribose-phosphate pyrophosphokinase family. (304 aa) |
| | AKF03487.1 | Threonine dehydratase, catabolic. (324 aa) |
| | trpF | Phosphoribosylanthranilate isomerase; Belongs to the TrpF family. (226 aa) |
| | AKF03779.1 | Cystathionine gamma-lyase. (390 aa) |
| | AKF03824.1 | Fructose-bisphosphate aldolase class I. (301 aa) |
| | tal | Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 3B subfamily. (215 aa) |
| | AKF04356.1 | 6-phosphofructokinase. (392 aa) |
| | AKF04533.1 | Glutamine-dependent 2-keto-4-methylthiobutyrate transaminase. (327 aa) |
| | AKF04534.1 | Cystathionine beta-synthase. (456 aa) |
| | AKF04559.1 | 3-isopropylmalate dehydrogenase. (353 aa) |
| | AKF04621.1 | Citrate synthase (si); Belongs to the citrate synthase family. (428 aa) |
| | AKF04696.1 | Asparagine synthetase. (642 aa) |
| | hisD | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (423 aa) |
| | AKF04928.1 | Aspartate aminotransferase. (447 aa) |
| | AKF04943.1 | D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (400 aa) |
| | AKF04954.1 | Argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 2 subfamily. (453 aa) |
| | AKF05076.1 | Acetolactate synthase large subunit; Belongs to the TPP enzyme family. (543 aa) |
| | proC | Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (282 aa) |
| | AKF05196.1 | Acetylornithine deacetylase. (404 aa) |
| | argA | N-acetylglutamate synthase; Belongs to the acetyltransferase family. ArgA subfamily. (447 aa) |
| | AKF05291.1 | 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate; Belongs to the BPG-independent phosphoglycerate mutase family. (538 aa) |
| | dapB | 4-hydroxy-tetrahydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (270 aa) |
| | dapA | 4-hydroxy-tetrahydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (245 aa) |
| | AKF05458.1 | Homoserine dehydrogenase. (425 aa) |
| | hisG | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. (239 aa) |
| | AKF05675.1 | Glutamine synthetase type I. (471 aa) |
| | AKF05819.1 | Hypothetical protein. (421 aa) |
| | AKF05900.1 | Anthranilate synthase, aminase component. (500 aa) |
| | AKF05928.1 | Cysteine synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (302 aa) |
| | AKF05929.1 | Serine acetyltransferase. (300 aa) |
| | AKF05952.1 | Acetolactate synthase large subunit; Belongs to the TPP enzyme family. (545 aa) |
| | argC | N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (349 aa) |
| | AKF05966.1 | Acetolactate synthase large subunit; Belongs to the TPP enzyme family. (557 aa) |
| | AKF05972.1 | Threonine dehydratase. (307 aa) |
| | AKF06144.1 | Hypothetical protein. (391 aa) |
| | aroQ | 3-dehydroquinate dehydratase II; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (167 aa) |
| | AKF06250.1 | Aconitate hydratase. (1063 aa) |
| | argH | Argininosuccinate lyase. (458 aa) |
| | lysA | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (433 aa) |
| | AKF06434.1 | Aspartokinase; Belongs to the aspartokinase family. (386 aa) |
| | hisZ | ATP phosphoribosyltransferase regulatory subunit; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. (466 aa) |
| | AKF06529.1 | Isocitrate dehydrogenase. (418 aa) |
| | pheA | Chorismate mutase I. (375 aa) |
| | aroA | 5-Enolpyruvylshikimate-3-phosphate synthase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (460 aa) |
| | AKF06614.1 | D-3-phosphoglycerate dehydrogenase; Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L- serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (406 aa) |
| | proA | Gamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (422 aa) |
| | AKF06671.1 | Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (449 aa) |
| | hisB | Imidazoleglycerol-phosphate dehydratase. (202 aa) |
| | hisH | Imidazole glycerol phosphate synthase amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (214 aa) |
| | hisA | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. (241 aa) |
| | hisF | Imidazole glycerol phosphate synthase cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (257 aa) |
| | AKF06709.1 | 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Belongs to the transferase hexapeptide repeat family. (280 aa) |
| | AKF06741.1 | Ribose 5-phosphate isomerase B. (147 aa) |
| | proB | Glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (363 aa) |
| | AKF06812.1 | Cysteine synthase. (310 aa) |
| | AKF06815.1 | Cysteine synthase. (325 aa) |
| | tpiA | Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (255 aa) |
| | pgk | Phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (396 aa) |
| | AKF06844.1 | NAD-dependent glyceraldehyde-3-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (514 aa) |
| | AKF06890.1 | D-alanine aminotransferase. (289 aa) |
| | AKF06911.1 | Aspartokinase; Belongs to the aspartokinase family. (407 aa) |
| | AKF07006.1 | Asparagine synthetase. (651 aa) |
| | glyA | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (417 aa) |
| | asd | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (330 aa) |
| | AKF07147.1 | Indole-3-glycerol phosphate synthase; Belongs to the TrpC family. (267 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (338 aa) |
| | AKF07213.1 | 5,10-methylenetetrahydrofolate reductase. (614 aa) |
| | argJ | Glutamate N-acetyltransferase; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (409 aa) |
| | ilvE | Branched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (302 aa) |
| | eno | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (396 aa) |
| | AKF07464.1 | 2-keto-3-deoxy-D-arabino-heptulosonate-7- phosphate synthase II. (470 aa) |
| | aroB | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. (509 aa) |
| | AKF07697.1 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1230 aa) |
| | AKF07707.1 | Ribose-phosphate pyrophosphokinase. (311 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (380 aa) |
| | AKF07781.1 | 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. (360 aa) |
| | AKF07797.1 | 3-isopropylmalate dehydratase large subunit. (655 aa) |
| | AKF07903.1 | Transketolase; Belongs to the transketolase family. (685 aa) |
| | rpiA | Ribose 5-phosphate isomerase A; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate. (242 aa) |
| | AKF07952.1 | Cysteine synthase. (316 aa) |
| | AKF07969.1 | Aspartate aminotransferase. (487 aa) |
| | AKF08054.1 | Chorismate mutase I. (397 aa) |
| | leuB | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (363 aa) |
| | AKF08057.1 | (R)-citramalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (535 aa) |
| | leuD | 3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (200 aa) |
| | leuC | 3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (480 aa) |
| | leuA | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (535 aa) |
| | ilvC | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (336 aa) |
| | AKF08062.1 | Acetolactate synthase small subunit. (196 aa) |
| | AKF08063.1 | Acetolactate synthase large subunit. (583 aa) |
| | ilvD | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (565 aa) |
| | AKF08077.1 | Glutamine-dependent 2-keto-4-methylthiobutyrate transaminase. (388 aa) |
| | AKF08117.1 | Cystathionine gamma-synthase. (382 aa) |
| | prs | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (314 aa) |
| | hisI | Phosphoribosyl-AMP cyclohydrolase; In the N-terminal section; belongs to the PRA-CH family. (218 aa) |
| | AKF08168.1 | Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1168 aa) |
| | hisC | Histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (366 aa) |
| | AKF08547.1 | Histidinol-phosphatase. (275 aa) |
| | trpB-2 | Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (397 aa) |
| | trpA | Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (259 aa) |
| | trpF-2 | Phosphoribosylanthranilate isomerase; Belongs to the TrpF family. (205 aa) |
| | AKF08602.1 | Low-specificity L-threonine aldolase. (344 aa) |
| | AKF08782.1 | Transketolase. (280 aa) |
| | AKF08783.1 | Transketolase. (319 aa) |
| | AKF08918.1 | Branched-chain amino acid aminotransferase. (349 aa) |
| | AKF08959.1 | Glutamate synthase [NADPH] large chain. (1527 aa) |
| | AKF08960.1 | Glutamate synthase [NADPH] small chain. (483 aa) |
| | AKF09149.1 | Cysteine synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (302 aa) |
| | AKF09160.1 | Citrate synthase (si); Belongs to the citrate synthase family. (352 aa) |
| | AKF09161.1 | Citrate synthase (si). (426 aa) |
| | AKF09204.1 | L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family. (479 aa) |
| | AKF09245.1 | Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline. (320 aa) |
| | argD | Acetylornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (404 aa) |
| | argB | Acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (290 aa) |
| | pfkA | 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily. (370 aa) |
| | dapF | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (277 aa) |
| | AKF10063.1 | Ribulose-phosphate 3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. (220 aa) |
| | AKF10224.1 | S-adenosylmethionine synthetase; Belongs to the AdoMet synthase family. (399 aa) |
| | AKF10688.1 | Aspartate aminotransferase. (400 aa) |
| | AKF11173.1 | Pyruvate kinase; Belongs to the pyruvate kinase family. (468 aa) |
| | AKF11391.1 | Shikimate 5-dehydrogenase I gamma. (273 aa) |
| | AKF11506.1 | Aspartate aminotransferase. (436 aa) |
| | serC | Phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (367 aa) |
