STRINGSTRING
carA carA AFD05446.1 AFD05446.1 tdk tdk purH purH purN purN apt apt AFD05771.1 AFD05771.1 AFD05779.1 AFD05779.1 guaA guaA AFD05782.1 AFD05782.1 AFD05794.1 AFD05794.1 pyrB pyrB AFD05802.1 AFD05802.1 AFD05824.1 AFD05824.1 AFD05852.1 AFD05852.1 AFD05853.1 AFD05853.1 pyrE pyrE AFD06047.1 AFD06047.1 AFD06404.1 AFD06404.1 purL purL surE surE AFD06768.1 AFD06768.1 AFD06789.1 AFD06789.1 AFD06806.1 AFD06806.1 purK purK purE purE AFD06919.1 AFD06919.1 purC purC folD folD AFD07074.1 AFD07074.1 pyrG pyrG AFD07216.1 AFD07216.1 AFD07217.1 AFD07217.1 AFD07218.1 AFD07218.1 AFD07220.1 AFD07220.1 AFD07299.1 AFD07299.1 purS purS thyA thyA AFD07335.1 AFD07335.1 pyrD pyrD AFD07458.1 AFD07458.1 fmt fmt purA purA guaB guaB AFD07700.1 AFD07700.1 adk adk surE-2 surE-2 AFD07991.1 AFD07991.1 AFD07999.1 AFD07999.1 fhs fhs AFD08220.1 AFD08220.1 AFD08221.1 AFD08221.1 gcvT gcvT AFD08269.1 AFD08269.1 AFD08398.1 AFD08398.1 gmk gmk AFD08414.1 AFD08414.1 AFD08532.1 AFD08532.1 AFD08886.1 AFD08886.1 AFD08887.1 AFD08887.1 AFD09001.1 AFD09001.1 purD purD AFD09152.1 AFD09152.1 purQ purQ glyA glyA dut dut gcvH gcvH ndk ndk AFD09402.1 AFD09402.1 gcvP gcvP
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
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a 3D structure is known or predicted
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carAPFAM: Carbamoyl-phosphate synthase small chain, CPSase domain; Glutamine amidotransferase class-I; Belongs to the CarA family. (379 aa)
AFD05446.1PFAM: Permease family. (431 aa)
tdkPFAM: Thymidine kinase. (191 aa)
purHPhosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM: AICARFT/IMPCHase bienzyme; MGS-like domain. (508 aa)
purNPhosphoribosylglycinamide formyltransferase, formyltetrahydrofolate-dependent; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (191 aa)
aptAdenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (177 aa)
AFD05771.1PFAM: Glutamine amidotransferases class-II. (633 aa)
AFD05779.1PFAM: Cytidine and deoxycytidylate deaminase zinc-binding region. (157 aa)
guaAGMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. (509 aa)
AFD05782.1tRNA/rRNA cytosine-C5-methylase; PFAM: NOL1/NOP2/sun family; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (389 aa)
AFD05794.1Folylpolyglutamate synthase/dihydrofolate synthase; PFAM: Mur ligase middle domain; Belongs to the folylpolyglutamate synthase family. (429 aa)
pyrBPFAM: Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (310 aa)
AFD05802.1Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase; PFAM: Phosphoribosyl transferase domain. (180 aa)
AFD05824.1Dihydroorotase, multifunctional complex type; PFAM: Amidohydrolase family. (446 aa)
AFD05852.1Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (788 aa)
AFD05853.1Ribonucleotide reductase, beta subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. (323 aa)
pyrEOrotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (213 aa)
AFD06047.1Dihydroorotase, multifunctional complex type; PFAM: Amidohydrolase family. (421 aa)
AFD06404.1Phosphoribosylaminoimidazole (AIR) synthetase; PFAM: AIR synthase related protein, C-terminal domain. (393 aa)
purLPhosphoribosylformylglycinamidine synthase II; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist [...] (751 aa)
surE5'/3'-nucleotidase SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (245 aa)
AFD06768.1methionyl-tRNA formyltransferase; PFAM: Formyl transferase. (312 aa)
AFD06789.1PFAM: Lyase; Adenylosuccinate lyase C-terminal; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (447 aa)
AFD06806.1Putative transcriptional regulator; PFAM: Uncharacterized ACR, COG1678; Belongs to the UPF0301 (AlgH) family. (185 aa)
purKPhosphoribosylaminoimidazole carboxylase, PurK protein; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (380 aa)
purEPhosphoribosylaminoimidazole carboxylase, PurE protein; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (177 aa)
AFD06919.1PFAM: Phosphorylase superfamily. (284 aa)
purCPhosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase; PFAM: SAICAR synthetase. (316 aa)
folD5,10-methylene-tetrahydrofolate dehydrogenase/methenyl tetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (292 aa)
AFD07074.1PFAM: Phosphoribulokinase / Uridine kinase family. (210 aa)
pyrGCTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (542 aa)
AFD07216.1Anaerobic ribonucleoside-triphosphate reductase; PFAM: ATP cone domain. (710 aa)
AFD07217.1Hypothetical protein. (59 aa)
AFD07218.1Anaerobic ribonucleoside-triphosphate reductase activating protein; PFAM: Radical SAM superfamily. (238 aa)
AFD07220.1PFAM: Copper resistance protein D. (149 aa)
AFD07299.1Orotidine 5''-phosphate decarboxylase, subfamily 2; PFAM: Orotidine 5'-phosphate decarboxylase / HUMPS family. (275 aa)
purSPhosphoribosylformylglycinamidine synthase, purS protein; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought [...] (83 aa)
thyAThymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (264 aa)
AFD07335.1Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. (167 aa)
pyrDDihydroorotate dehydrogenase, subfamily 2; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (343 aa)
AFD07458.1MazG family protein; PFAM: MazG nucleotide pyrophosphohydrolase domain. (265 aa)
fmtmethionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. (311 aa)
purAAdenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (425 aa)
guaBInosine-5''-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (490 aa)
AFD07700.15'-nucleotidase/2',3'-cyclic phosphodiesterase-like hydrolase; PFAM: Calcineurin-like phosphoesterase; Belongs to the 5'-nucleotidase family. (305 aa)
adkAdenylate kinase family protein; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (189 aa)
surE-25'/3'-nucleotidase SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (256 aa)
AFD07991.1Purine nucleoside phosphorylase I, inosine and guanosine-specific; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (271 aa)
AFD07999.1Formyltetrahydrofolate hydrolase; PFAM: ACT domain. (73 aa)
fhsFormyltetrahydrofolate synthetase; PFAM: Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. (553 aa)
AFD08220.15-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1231 aa)
AFD08221.1PFAM: Methylenetetrahydrofolate reductase; TIGRFAM: 5,10-methylenetetrahydrofolate reductase, prokaryotic form; Belongs to the methylenetetrahydrofolate reductase family. (317 aa)
gcvTGlycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. (358 aa)
AFD08269.1Non-canonical purine NTP pyrophosphatase, rdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (192 aa)
AFD08398.1PFAM: Phosphoribosyl transferase domain; TIGRFAM: hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (176 aa)
gmkGuanylate kinase; Essential for recycling GMP and indirectly, cGMP. (198 aa)
AFD08414.1Ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. (1101 aa)
AFD08532.1Carbamoyl-phosphate synthase, large subunit; PFAM: Carbamoyl-phosphate synthase L chain, ATP binding domain; Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Carbamoyl-phosphate synthase L chain, N-terminal domain; TIGRFAM: carbamoyl-phosphate synthase, large subunit. (937 aa)
AFD08886.1PFAM: Ribonucleotide reductase, small chain. (324 aa)
AFD08887.1PFAM: Ribonucleotide reductase, barrel domain; TIGRFAM: ribonucleoside-diphosphate reductase, alpha chain. (564 aa)
AFD09001.1TIGRFAM: deoxycytidine triphosphate deaminase. (178 aa)
purDPhosphoribosylamine--glycine ligase; PFAM: Phosphoribosylglycinamide synthetase, N domain; Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Phosphoribosylglycinamide synthetase, C domain; TIGRFAM: phosphoribosylamine--glycine ligase; Belongs to the GARS family. (424 aa)
AFD09152.1PFAM: Phosphoribosyl transferase domain; TIGRFAM: uracil phosphoribosyltransferase. (214 aa)
purQPhosphoribosylformylglycinamidine synthase I; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist i [...] (229 aa)
glyAGlycine/serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (423 aa)
dutDeoxyuridine 5'-triphosphate nucleotidohydrolase Dut; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. (144 aa)
gcvHGlycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (126 aa)
ndkNucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (139 aa)
AFD09402.1Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase; PFAM: Phosphoribosyl transferase domain. (168 aa)
gcvPGlycine dehydrogenase, decarboxylating; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (976 aa)
Your Current Organism:
Solitalea canadensis
NCBI taxonomy Id: 929556
Other names: S. canadensis DSM 3403, Solitalea canadensis DSM 3403, Solitalea canadensis IFO 15130, Solitalea canadensis NBRC 15130, Solitalea canadensis str. DSM 3403, Solitalea canadensis strain DSM 3403
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