STRINGSTRING
carA carA tdk tdk AFD05779.1 AFD05779.1 pyrB pyrB AFD05802.1 AFD05802.1 cmk cmk AFD05824.1 AFD05824.1 AFD05852.1 AFD05852.1 AFD05853.1 AFD05853.1 pyrE pyrE AFD06047.1 AFD06047.1 surE surE AFD06919.1 AFD06919.1 AFD07074.1 AFD07074.1 AFD07156.1 AFD07156.1 pyrG pyrG AFD07216.1 AFD07216.1 AFD07299.1 AFD07299.1 thyA thyA pyrD pyrD AFD07700.1 AFD07700.1 surE-2 surE-2 AFD07991.1 AFD07991.1 AFD08414.1 AFD08414.1 pyrH pyrH AFD08532.1 AFD08532.1 AFD08886.1 AFD08886.1 AFD08887.1 AFD08887.1 AFD09001.1 AFD09001.1 AFD09152.1 AFD09152.1 dut dut ndk ndk AFD09402.1 AFD09402.1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
carAPFAM: Carbamoyl-phosphate synthase small chain, CPSase domain; Glutamine amidotransferase class-I; Belongs to the CarA family. (379 aa)
tdkPFAM: Thymidine kinase. (191 aa)
AFD05779.1PFAM: Cytidine and deoxycytidylate deaminase zinc-binding region. (157 aa)
pyrBPFAM: Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (310 aa)
AFD05802.1Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase; PFAM: Phosphoribosyl transferase domain. (180 aa)
cmkPFAM: Cytidylate kinase. (224 aa)
AFD05824.1Dihydroorotase, multifunctional complex type; PFAM: Amidohydrolase family. (446 aa)
AFD05852.1Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (788 aa)
AFD05853.1Ribonucleotide reductase, beta subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. (323 aa)
pyrEOrotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (213 aa)
AFD06047.1Dihydroorotase, multifunctional complex type; PFAM: Amidohydrolase family. (421 aa)
surE5'/3'-nucleotidase SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (245 aa)
AFD06919.1PFAM: Phosphorylase superfamily. (284 aa)
AFD07074.1PFAM: Phosphoribulokinase / Uridine kinase family. (210 aa)
AFD07156.1PFAM: Deoxynucleoside kinase. (206 aa)
pyrGCTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (542 aa)
AFD07216.1Anaerobic ribonucleoside-triphosphate reductase; PFAM: ATP cone domain. (710 aa)
AFD07299.1Orotidine 5''-phosphate decarboxylase, subfamily 2; PFAM: Orotidine 5'-phosphate decarboxylase / HUMPS family. (275 aa)
thyAThymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (264 aa)
pyrDDihydroorotate dehydrogenase, subfamily 2; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (343 aa)
AFD07700.15'-nucleotidase/2',3'-cyclic phosphodiesterase-like hydrolase; PFAM: Calcineurin-like phosphoesterase; Belongs to the 5'-nucleotidase family. (305 aa)
surE-25'/3'-nucleotidase SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (256 aa)
AFD07991.1Purine nucleoside phosphorylase I, inosine and guanosine-specific; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (271 aa)
AFD08414.1Ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. (1101 aa)
pyrHUridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (235 aa)
AFD08532.1Carbamoyl-phosphate synthase, large subunit; PFAM: Carbamoyl-phosphate synthase L chain, ATP binding domain; Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Carbamoyl-phosphate synthase L chain, N-terminal domain; TIGRFAM: carbamoyl-phosphate synthase, large subunit. (937 aa)
AFD08886.1PFAM: Ribonucleotide reductase, small chain. (324 aa)
AFD08887.1PFAM: Ribonucleotide reductase, barrel domain; TIGRFAM: ribonucleoside-diphosphate reductase, alpha chain. (564 aa)
AFD09001.1TIGRFAM: deoxycytidine triphosphate deaminase. (178 aa)
AFD09152.1PFAM: Phosphoribosyl transferase domain; TIGRFAM: uracil phosphoribosyltransferase. (214 aa)
dutDeoxyuridine 5'-triphosphate nucleotidohydrolase Dut; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. (144 aa)
ndkNucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (139 aa)
AFD09402.1Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase; PFAM: Phosphoribosyl transferase domain. (168 aa)
Your Current Organism:
Solitalea canadensis
NCBI taxonomy Id: 929556
Other names: S. canadensis DSM 3403, Solitalea canadensis DSM 3403, Solitalea canadensis IFO 15130, Solitalea canadensis NBRC 15130, Solitalea canadensis str. DSM 3403, Solitalea canadensis strain DSM 3403
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