(74 nodes) Fatty acid beta-oxidation, and Valine, leucine and isoleucine degradation network (Sarcophilus harrisii)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC100914188	Uncharacterized protein. (139 aa)
	BDH2	3-hydroxybutyrate dehydrogenase 2. (246 aa)
	G3VBM4_SARHA	Uncharacterized protein. (122 aa)
	G3VCA3_SARHA	Uncharacterized protein. (299 aa)
	ACADSB	Acyl-CoA dehydrogenase short/branched chain. (433 aa)
	ACAA2	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. (397 aa)
	ACAT2	Acetyl-CoA acetyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family. (338 aa)
	PCCB	Propionyl-CoA carboxylase subunit beta. (562 aa)
	LOC100916381	3HCDH_N domain-containing protein. (106 aa)
	ECI1	Enoyl-CoA delta isomerase 1; Belongs to the enoyl-CoA hydratase/isomerase family. (247 aa)
	AMACR	Alpha-methylacyl-CoA racemase. (316 aa)
	ACSM4	Acyl-CoA synthetase medium chain family member 4. (580 aa)
	HACL1	2-hydroxyacyl-CoA lyase 1; Belongs to the TPP enzyme family. (519 aa)
	ACSM3	Acyl-CoA synthetase medium chain family member 3. (583 aa)
	HMGCR	3-hydroxy-3-methylglutaryl coenzyme A reductase. (879 aa)
	G3VPG5_SARHA	Aldedh domain-containing protein. (438 aa)
	G3VPT1_SARHA	Uncharacterized protein. (379 aa)
	G3VPT3_SARHA	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family. (515 aa)
	ETFB	Electron transfer flavoprotein subunit beta. (255 aa)
	MCCC2	Methylcrotonoyl-CoA carboxylase 2. (526 aa)
	HADH	Hydroxyacyl-CoA dehydrogenase. (317 aa)
	HMGCLL1	3-hydroxymethyl-3-methylglutaryl-CoA lyase like 1. (236 aa)
	HSD17B4	Hydroxysteroid 17-beta dehydrogenase 4. (736 aa)
	HMGCL	3-hydroxy-3-methylglutaryl-CoA lyase. (327 aa)
	ACSS3	Acyl-CoA synthetase short chain family member 3. (536 aa)
	AACS	Acetoacetyl-CoA synthetase. (631 aa)
	DIP2B	Disco interacting protein 2 homolog B. (1527 aa)
	ECI2	Enoyl-CoA delta isomerase 2. (393 aa)
	G3VW97_SARHA	Thiolase_N domain-containing protein. (297 aa)
	CARTPT	CART prepropeptide. (114 aa)
	ACAA1	Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. (345 aa)
	OXCT1	Uncharacterized protein. (328 aa)
	CPT2	Carnitine palmitoyltransferase 2; Belongs to the carnitine/choline acetyltransferase family. (608 aa)
	DIP2A	Disco interacting protein 2 homolog A. (1341 aa)
	G3VZY2_SARHA	Carn_acyltransf domain-containing protein; Belongs to the carnitine/choline acetyltransferase family. (635 aa)
	ACADM	Acyl-CoA dehydrogenase medium chain. (326 aa)
	ACADVL	Acyl-CoA dehydrogenase very long chain. (704 aa)
	G3W4F2_SARHA	Uncharacterized protein. (600 aa)
	ACOX2	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (679 aa)
	G3W7T9_SARHA	Uncharacterized protein; Belongs to the enoyl-CoA hydratase/isomerase family. (126 aa)
	XYLB	Xylulokinase. (532 aa)
	ECHS1	Enoyl-CoA hydratase, short chain 1; Belongs to the enoyl-CoA hydratase/isomerase family. (290 aa)
	HMGCS1	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (524 aa)
	G3WC98_SARHA	Uncharacterized protein. (997 aa)
	ADHFE1	Fe-ADH domain-containing protein. (467 aa)
	G3WE10_SARHA	Carn_acyltransf domain-containing protein; Belongs to the carnitine/choline acetyltransferase family. (624 aa)
	EHHADH	Enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase. (606 aa)
	VAT1	Vesicle amine transport 1. (265 aa)
	ACAT1	Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. (427 aa)
	HSDL2	Hydroxysteroid dehydrogenase like 2. (524 aa)
	ETFDH	Electron transfer flavoprotein-ubiquinone oxidoreductase; Accepts electrons from ETF and reduces ubiquinone. (620 aa)
	ACAD8	Acyl-CoA dehydrogenase family member 8. (415 aa)
	G3WLY2_SARHA	PKS_ER domain-containing protein. (410 aa)
	G3WM72_SARHA	Lipoyl-binding domain-containing protein. (106 aa)
	HADHA	Hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha; Belongs to the enoyl-CoA hydratase/isomerase family. (765 aa)
	HADHB	Hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta; Belongs to the thiolase-like superfamily. Thiolase family. (473 aa)
	HIBCH	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite; Belongs to the enoyl-CoA hydratase/isomerase family. (386 aa)
	PCCA	Uncharacterized protein. (349 aa)
	ACADS	Acyl-CoA dehydrogenase short chain. (395 aa)
	HIBADH	3-hydroxyisobutyrate dehydrogenase; Belongs to the HIBADH-related family. (300 aa)
	HMGCS2	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (509 aa)
	MCCC1	Methylcrotonoyl-CoA carboxylase 1. (698 aa)
	ETFA	Electron transfer flavoprotein subunit alpha. (333 aa)
	ACOX3	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (701 aa)
	LOC100934782	CoA carboxyltransferase N-terminal domain-containing protein. (611 aa)
	SORD	Sorbitol dehydrogenase. (358 aa)
	ACOX1	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (645 aa)
	SCP2D1	SCP2 sterol binding domain containing 1. (161 aa)
	ECHDC1	Ethylmalonyl-CoA decarboxylase 1; Belongs to the enoyl-CoA hydratase/isomerase family. (339 aa)
	ALDH6A1	Aldehyde dehydrogenase 6 family member A1. (506 aa)
	ACSM5	Acyl-CoA synthetase medium chain family member 5. (607 aa)
	LOC100932504	Uncharacterized protein. (586 aa)
	CRAT	Carnitine O-acetyltransferase; Belongs to the carnitine/choline acetyltransferase family. (627 aa)
	LOC100932766	Uncharacterized protein. (569 aa)

Your Current Organism:

Sarcophilus harrisii

NCBI taxonomy Id: 9305
Other names: S. harrisii, Sarcophilus laniarius, Tasmanian devil

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AACS	ACAA1	ENSSHAP00000006439	ENSSHAP00000007735	Acetoacetyl-CoA synthetase.	Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	0.495
AACS	ACAA2	ENSSHAP00000006439	ENSSHAP00000001391	Acetoacetyl-CoA synthetase.	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.	0.472
AACS	ACAT1	ENSSHAP00000006439	ENSSHAP00000013889	Acetoacetyl-CoA synthetase.	Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	0.959
AACS	ACAT2	ENSSHAP00000006439	ENSSHAP00000002089	Acetoacetyl-CoA synthetase.	Acetyl-CoA acetyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family.	0.947
AACS	ACOX1	ENSSHAP00000006439	ENSSHAP00000020666	Acetoacetyl-CoA synthetase.	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family.	0.438
AACS	ACOX2	ENSSHAP00000006439	ENSSHAP00000010520	Acetoacetyl-CoA synthetase.	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family.	0.438
AACS	ACOX3	ENSSHAP00000006439	ENSSHAP00000019077	Acetoacetyl-CoA synthetase.	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family.	0.419
AACS	ADHFE1	ENSSHAP00000006439	ENSSHAP00000013642	Acetoacetyl-CoA synthetase.	Fe-ADH domain-containing protein.	0.521
AACS	BDH2	ENSSHAP00000006439	ENSSHAP00000000523	Acetoacetyl-CoA synthetase.	3-hydroxybutyrate dehydrogenase 2.	0.927
AACS	CARTPT	ENSSHAP00000006439	ENSSHAP00000007655	Acetoacetyl-CoA synthetase.	CART prepropeptide.	0.491
AACS	DIP2A	ENSSHAP00000006439	ENSSHAP00000008586	Acetoacetyl-CoA synthetase.	Disco interacting protein 2 homolog A.	0.476
AACS	DIP2B	ENSSHAP00000006439	ENSSHAP00000006732	Acetoacetyl-CoA synthetase.	Disco interacting protein 2 homolog B.	0.476
AACS	ECHDC1	ENSSHAP00000006439	ENSSHAP00000022052	Acetoacetyl-CoA synthetase.	Ethylmalonyl-CoA decarboxylase 1; Belongs to the enoyl-CoA hydratase/isomerase family.	0.437
AACS	ECHS1	ENSSHAP00000006439	ENSSHAP00000012626	Acetoacetyl-CoA synthetase.	Enoyl-CoA hydratase, short chain 1; Belongs to the enoyl-CoA hydratase/isomerase family.	0.437
AACS	ECI1	ENSSHAP00000006439	ENSSHAP00000003086	Acetoacetyl-CoA synthetase.	Enoyl-CoA delta isomerase 1; Belongs to the enoyl-CoA hydratase/isomerase family.	0.413
AACS	ECI2	ENSSHAP00000006439	ENSSHAP00000006931	Acetoacetyl-CoA synthetase.	Enoyl-CoA delta isomerase 2.	0.465
AACS	EHHADH	ENSSHAP00000006439	ENSSHAP00000013720	Acetoacetyl-CoA synthetase.	Enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase.	0.938
AACS	G3VBM4_SARHA	ENSSHAP00000006439	ENSSHAP00000000578	Acetoacetyl-CoA synthetase.	Uncharacterized protein.	0.406
AACS	G3VCA3_SARHA	ENSSHAP00000006439	ENSSHAP00000000807	Acetoacetyl-CoA synthetase.	Uncharacterized protein.	0.460
AACS	G3VPG5_SARHA	ENSSHAP00000006439	ENSSHAP00000005070	Acetoacetyl-CoA synthetase.	Aldedh domain-containing protein.	0.478