(93 nodes) Positive regulation of cell-substrate adhesion network (Sarcophilus harrisii)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	RSU1	Ras suppressor protein 1. (183 aa)
	UTRN	Utrophin. (3436 aa)
	MAP4K4	Mitogen-activated protein kinase kinase kinase kinase 4. (1248 aa)
	C1QBP	Complement C1q binding protein. (229 aa)
	HSD17B12	Hydroxysteroid 17-beta dehydrogenase 12; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (231 aa)
	DISC1	Uncharacterized protein. (366 aa)
	LIMS1	LIM and senescent cell antigen-like-containing domain protein; Adapter protein in a cytoplasmic complex linking beta- integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors. (337 aa)
	G3VJI2_SARHA	Uncharacterized protein. (103 aa)
	CDK6	Cyclin dependent kinase 6. (202 aa)
	ARL2	Uncharacterized protein; Belongs to the small GTPase superfamily. Arf family. (184 aa)
	EMID1	EMI domain containing 1. (432 aa)
	CSF1	Uncharacterized protein. (560 aa)
	JUP	Junction plakoglobin. (745 aa)
	CSPG5	Chondroitin sulfate proteoglycan 5. (503 aa)
	CCDC80	Coiled-coil domain containing 80. (943 aa)
	TSC1	TSC complex subunit 1. (1017 aa)
	FUT1	L-Fucosyltransferase; Belongs to the glycosyltransferase 11 family. (300 aa)
	RREB1	Ras responsive element binding protein 1. (1655 aa)
	HPSE	Heparanase. (540 aa)
	G3VTU3_SARHA	Uncharacterized protein. (384 aa)
	THY1	Thy-1 cell surface antigen. (162 aa)
	SPOCK2	SPARC (osteonectin), cwcv and kazal like domains proteoglycan 2. (338 aa)
	LIMS2	LIM and senescent cell antigen-like-containing domain protein; Adapter protein in a cytoplasmic complex linking beta- integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors. (354 aa)
	G3VW59_SARHA	Uncharacterized protein. (208 aa)
	LRRC45	Leucine rich repeat containing 45. (685 aa)
	EPHA1	EPH receptor A1. (979 aa)
	G3VXF2_SARHA	Calreticulin. (419 aa)
	TSTA3	Epimerase domain-containing protein. (282 aa)
	NID1	Uncharacterized protein. (79 aa)
	NEDD9	Neural precursor cell expressed, developmentally down-regulated 9. (832 aa)
	FBLN2	Fibulin 2. (1188 aa)
	ITGB1BP1	Integrin subunit beta 1 binding protein 1. (203 aa)
	DAB2	PID domain-containing protein. (457 aa)
	NDNF	Neuron derived neurotrophic factor. (569 aa)
	MYADM	Myeloid associated differentiation marker. (321 aa)
	KDR	Kinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1349 aa)
	EGFL6	EGF like domain multiple 6. (502 aa)
	PPM1F	Protein phosphatase, Mg2+/Mn2+ dependent 1F. (417 aa)
	CDH13	Cadherin 13. (608 aa)
	SKAP1	Src kinase associated phosphoprotein 1. (281 aa)
	FN1	Fibronectin 1. (2302 aa)
	ILK	Integrin linked kinase. (452 aa)
	FERMT1	Fermitin family member 1. (677 aa)
	G3W731_SARHA	Uncharacterized protein. (178 aa)
	TRIOBP	PH domain-containing protein. (2176 aa)
	EMP2	Epithelial membrane protein 2; Functions as a key regulator of cell membrane composition by regulating proteins surface expression. Also, plays a role in regulation of processes including cell migration, cell proliferation, cell contraction and cell adhesion; Belongs to the PMP-22/EMP/MP20 family. (171 aa)
	CARMIL1	Uncharacterized protein. (98 aa)
	CCL28	C-C motif chemokine. (110 aa)
	COL16A1	Collagen type XVI alpha 1 chain. (1614 aa)
	P4HB	Protein disulfide-isomerase. (510 aa)
	RELL2	RELT like 2. (301 aa)
	CIB1	Calcium and integrin binding 1. (189 aa)
	G3WF14_SARHA	Uncharacterized protein. (326 aa)
	COL8A1	Collagen type VIII alpha 1 chain. (741 aa)
	VIT	Vitrin. (644 aa)
	EMILIN1	EMI domain-containing protein. (133 aa)
	ABI3BP	ABI family member 3 binding protein. (1122 aa)
	POLDIP2	DNA polymerase delta interacting protein 2. (333 aa)
	CASS4	Cas scaffold protein family member 4. (811 aa)
	VTN	SMB domain-containing protein. (474 aa)
	CCN1	Cellular communication network factor 1. (382 aa)
	EPB41L5	Erythrocyte membrane protein band 4.1 like 5. (732 aa)
	EGFLAM	EGF like, fibronectin type III and laminin G domains. (1023 aa)
	RIN2	Ras and Rab interactor 2. (895 aa)
	TESK1	Testis associated actin remodelling kinase 1. (572 aa)
	JAK2	Tyrosine-protein kinase. (1137 aa)
	PDGFB	Platelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
	CALR	Calreticulin. (418 aa)
	NRP1	Neuropilin; Belongs to the neuropilin family. (857 aa)
	VEGFA	Vascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (359 aa)
	BRAF	B-Raf proto-oncogene, serine/threonine kinase. (716 aa)
	WNT4	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (264 aa)
	S100A10	S100 calcium binding protein A10; Belongs to the S-100 family. (97 aa)
	CDC42	Cell division cycle 42. (229 aa)
	ARPC2	Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (290 aa)
	MYOC	Myocilin. (498 aa)
	OLFM4	Olfactomedin 4. (448 aa)
	CCL21	C-C motif chemokine ligand 21. (139 aa)
	UNC13D	Unc-13 homolog D. (1093 aa)
	ITGB3	Integrin beta; Belongs to the integrin beta chain family. (784 aa)
	DMTN	HP domain-containing protein. (401 aa)
	PTPRJ	Protein tyrosine phosphatase receptor type J. (1298 aa)
	PLEKHA2	Pleckstrin homology domain containing A2. (424 aa)
	ECM2	Uncharacterized protein. (216 aa)
	G3VAV2_SARHA	Uncharacterized protein. (197 aa)
	FERMT2	Fermitin family member 2. (687 aa)
	FLNA	Filamin A. (2520 aa)
	NPNT	Nephronectin. (436 aa)
	CRKL	CRK like proto-oncogene, adaptor protein. (194 aa)
	EFEMP2	EGF containing fibulin extracellular matrix protein 2. (447 aa)
	PTK2B	Protein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1012 aa)
	G3VG42_SARHA	Uncharacterized protein. (392 aa)
	AGR2	Anterior gradient 2, protein disulphide isomerase family member. (173 aa)

Your Current Organism:

Sarcophilus harrisii

NCBI taxonomy Id: 9305
Other names: S. harrisii, Sarcophilus laniarius, Tasmanian devil

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARPC2	CASS4	ENSSHAP00000019615	ENSSHAP00000014842	Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.	Cas scaffold protein family member 4.	0.499
ARPC2	CDC42	ENSSHAP00000019615	ENSSHAP00000019325	Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.	Cell division cycle 42.	0.639
ARPC2	NEDD9	ENSSHAP00000019615	ENSSHAP00000008781	Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.	Neural precursor cell expressed, developmentally down-regulated 9.	0.499
ARPC2	PTK2B	ENSSHAP00000019615	ENSSHAP00000002068	Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.	Protein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.447
BRAF	G3VAV2_SARHA	ENSSHAP00000018862	ENSSHAP00000000306	B-Raf proto-oncogene, serine/threonine kinase.	Uncharacterized protein.	0.514
BRAF	ITGB3	ENSSHAP00000018862	ENSSHAP00000020984	B-Raf proto-oncogene, serine/threonine kinase.	Integrin beta; Belongs to the integrin beta chain family.	0.498
BRAF	TSC1	ENSSHAP00000018862	ENSSHAP00000006010	B-Raf proto-oncogene, serine/threonine kinase.	TSC complex subunit 1.	0.501
C1QBP	JUP	ENSSHAP00000002759	ENSSHAP00000004947	Complement C1q binding protein.	Junction plakoglobin.	0.403
C1QBP	VTN	ENSSHAP00000002759	ENSSHAP00000014892	Complement C1q binding protein.	SMB domain-containing protein.	0.496
CALR	G3VXF2_SARHA	ENSSHAP00000017629	ENSSHAP00000007857	Calreticulin.	Calreticulin.	0.902
CALR	P4HB	ENSSHAP00000017629	ENSSHAP00000012907	Calreticulin.	Protein disulfide-isomerase.	0.863
CALR	TSC1	ENSSHAP00000017629	ENSSHAP00000006010	Calreticulin.	TSC complex subunit 1.	0.537
CASS4	ARPC2	ENSSHAP00000014842	ENSSHAP00000019615	Cas scaffold protein family member 4.	Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.	0.499
CASS4	CRKL	ENSSHAP00000014842	ENSSHAP00000001508	Cas scaffold protein family member 4.	CRK like proto-oncogene, adaptor protein.	0.744
CASS4	PTK2B	ENSSHAP00000014842	ENSSHAP00000002068	Cas scaffold protein family member 4.	Protein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.676
CDC42	ARPC2	ENSSHAP00000019325	ENSSHAP00000019615	Cell division cycle 42.	Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.	0.639
CDC42	CRKL	ENSSHAP00000019325	ENSSHAP00000001508	Cell division cycle 42.	CRK like proto-oncogene, adaptor protein.	0.523
CDC42	EPHA1	ENSSHAP00000019325	ENSSHAP00000007844	Cell division cycle 42.	EPH receptor A1.	0.592
CDC42	FLNA	ENSSHAP00000019325	ENSSHAP00000001182	Cell division cycle 42.	Filamin A.	0.741
CDC42	G3VAV2_SARHA	ENSSHAP00000019325	ENSSHAP00000000306	Cell division cycle 42.	Uncharacterized protein.	0.458