STRINGSTRING
PTK2 PTK2 PDGFC PDGFC MYDGF MYDGF LOC100921027 LOC100921027 SEMA3E SEMA3E FGR FGR ROR2 ROR2 G3VNL0_SARHA G3VNL0_SARHA SERPINA12 SERPINA12 SEMA4D SEMA4D NEDD4 NEDD4 NCF1 NCF1 RELN RELN DCN DCN RGL2 RGL2 CAT CAT G3W0M2_SARHA G3W0M2_SARHA CBL CBL IGF1 IGF1 KDR KDR UNC5B UNC5B F2R F2R AGAP2 AGAP2 FN1 FN1 UBE3A UBE3A HCST HCST FGF2 FGF2 HCLS1 HCLS1 PPARD PPARD PIK3AP1 PIK3AP1 FLT1 FLT1 AGT AGT TGFB2 TGFB2 NTRK3 NTRK3 MYOC MYOC LEP LEP NTRK1 NTRK1 ROR1 ROR1 G3WV15_SARHA G3WV15_SARHA PTPN6 PTPN6 GPER1 GPER1 HGF HGF NKX3-1 NKX3-1 WNT16 WNT16 PDGFB PDGFB JAK2 JAK2 G3WQ31_SARHA G3WQ31_SARHA NTRK2 NTRK2 CSF3 CSF3 IGF1R IGF1R PRR5L PRR5L HAX1 HAX1 SIRT1 SIRT1 FSHR FSHR IL18 IL18 G3WEP2_SARHA G3WEP2_SARHA G3WE02_SARHA G3WE02_SARHA G3WCM7_SARHA G3WCM7_SARHA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PTK2Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1052 aa)
PDGFCPlatelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (345 aa)
MYDGFUncharacterized protein. (95 aa)
LOC100921027Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1183 aa)
SEMA3ESemaphorin 3E; Belongs to the semaphorin family. (737 aa)
FGRTyrosine-protein kinase. (531 aa)
ROR2Receptor tyrosine kinase like orphan receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1022 aa)
G3VNL0_SARHAUncharacterized protein. (333 aa)
SERPINA12SERPIN domain-containing protein; Belongs to the serpin family. (416 aa)
SEMA4DSemaphorin 4D; Belongs to the semaphorin family. (876 aa)
NEDD4NEDD4 E3 ubiquitin protein ligase. (1269 aa)
NCF1Neutrophil cytosolic factor 1. (407 aa)
RELNReelin. (3251 aa)
DCNDecorin; May affect the rate of fibrils formation. (360 aa)
RGL2Ral guanine nucleotide dissociation stimulator like 2. (777 aa)
CATCatalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. (527 aa)
G3W0M2_SARHATyrosine-protein kinase receptor. (530 aa)
CBLCbl proto-oncogene. (774 aa)
IGF1Insulin like growth factor 1. (130 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1349 aa)
UNC5BUnc-5 netrin receptor B. (1004 aa)
F2RCoagulation factor II thrombin receptor; Belongs to the G-protein coupled receptor 1 family. (426 aa)
AGAP2ArfGAP with GTPase domain, ankyrin repeat and PH domain 2. (1167 aa)
FN1Fibronectin 1. (2302 aa)
UBE3AUbiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. (878 aa)
HCSTUncharacterized protein. (80 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (203 aa)
HCLS1Hematopoietic cell-specific Lyn substrate 1. (558 aa)
PPARDPeroxisome proliferator activated receptor delta. (442 aa)
PIK3AP1Phosphoinositide-3-kinase adaptor protein 1. (806 aa)
FLT1Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1341 aa)
AGTSERPIN domain-containing protein; Belongs to the serpin family. (484 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (409 aa)
NTRK3Tyrosine-protein kinase receptor. (825 aa)
MYOCMyocilin. (498 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
NTRK1Tyrosine-protein kinase receptor. (792 aa)
ROR1Receptor tyrosine kinase like orphan receptor 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (882 aa)
G3WV15_SARHAUncharacterized protein. (542 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (596 aa)
GPER1G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (372 aa)
HGFHepatocyte growth factor; Belongs to the peptidase S1 family. (761 aa)
NKX3-1NK3 homeobox 1. (252 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (373 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
JAK2Tyrosine-protein kinase. (1137 aa)
G3WQ31_SARHARecep_L_domain domain-containing protein. (181 aa)
NTRK2Ig-like domain-containing protein. (310 aa)
CSF3Colony stimulating factor 3. (221 aa)
IGF1RTyrosine-protein kinase receptor. (1061 aa)
PRR5LProline rich 5 like. (369 aa)
HAX1HCLS1-associated protein X-1; Recruits the Arp2/3 complex to the cell cortex and regulates reorganization of the cortical actin cytoskeleton via its interaction with KCNC3 and the Arp2/3 complex. Slows down the rate of inactivation of KCNC3 channels. Promotes GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. Promotes cell survival. May regulate intracellular calcium pools. (277 aa)
SIRT1Sirtuin 1. (597 aa)
FSHRFollicle-stimulating hormone receptor; G protein-coupled receptor for follitropin, the follicle- stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways. (694 aa)
IL18Uncharacterized protein. (201 aa)
G3WEP2_SARHAUncharacterized protein. (212 aa)
G3WE02_SARHAUncharacterized protein. (212 aa)
G3WCM7_SARHAUncharacterized protein; Belongs to the semaphorin family. (590 aa)
Your Current Organism:
Sarcophilus harrisii
NCBI taxonomy Id: 9305
Other names: S. harrisii, Sarcophilus laniarius, Tasmanian devil
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