STRINGSTRING
SPDL1 SPDL1 FBXO5 FBXO5 CDC26 CDC26 CDC27 CDC27 DYNC1LI1 DYNC1LI1 PCID2 PCID2 ANAPC5 ANAPC5 TTK TTK XRCC3 XRCC3 MAD1L1 MAD1L1 MAD2L1BP MAD2L1BP ANAPC7 ANAPC7 TPR TPR CDT1 CDT1 NDC80 NDC80 CUL3 CUL3 LCMT1 LCMT1 APC APC UBE2C UBE2C NSMCE2 NSMCE2 ZWILCH ZWILCH ANAPC15 ANAPC15 KLHL22 KLHL22 CENPE CENPE ANAPC4 ANAPC4 BUB1 BUB1 GEN1 GEN1 PLK1 PLK1 RIOK2 RIOK2 BCL7A BCL7A TEX14 TEX14 MAD2L1 MAD2L1 TRIP13 TRIP13 USP44 USP44 CDC16 CDC16 PSMG2 PSMG2 G3W9F2_SARHA G3W9F2_SARHA BUB3 BUB3 BCL7C BCL7C ATM ATM CDC23 CDC23 KNTC1 KNTC1 BUB1B BUB1B CDC6 CDC6 ZW10 ZW10 RB1 RB1 ZNF207 ZNF207 BIRC5 BIRC5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SPDL1Protein Spindly; Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex. Also required for correct spindle orientation. Does not appear to be required for the removal of spindle assembly checkpoint (SAC) proteins from the kinetochore upon bipolar spindle attachment. (599 aa)
FBXO5F-box protein 5. (448 aa)
CDC26Cell division cycle 26. (85 aa)
CDC27Cell division cycle 27. (821 aa)
DYNC1LI1Dynein light intermediate chain; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. (471 aa)
PCID2PCI domain containing 2. (406 aa)
ANAPC5Anaphase promoting complex subunit 5. (672 aa)
TTKTTK protein kinase. (843 aa)
XRCC3DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (351 aa)
MAD1L1Uncharacterized protein. (471 aa)
MAD2L1BPMAD2L1 binding protein. (269 aa)
ANAPC7Anaphase promoting complex subunit 7. (565 aa)
TPRTranslocated promoter region, nuclear basket protein. (2345 aa)
CDT1Chromatin licensing and DNA replication factor 1. (422 aa)
NDC80NDC80 kinetochore complex component. (644 aa)
CUL3Cullin 3; Belongs to the cullin family. (684 aa)
LCMT1Uncharacterized protein. (173 aa)
APCUncharacterized protein. (2704 aa)
UBE2CUbiquitin conjugating enzyme E2 C; Belongs to the ubiquitin-conjugating enzyme family. (196 aa)
NSMCE2U-box domain-containing protein. (169 aa)
ZWILCHZwilch kinetochore protein. (570 aa)
ANAPC15Anaphase promoting complex subunit 15. (122 aa)
KLHL22BTB domain-containing protein. (609 aa)
CENPECentromere protein E; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (2678 aa)
ANAPC4Anaphase-promoting complex subunit 4; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. Belongs to the APC4 family. (768 aa)
BUB1BUB1 mitotic checkpoint serine/threonine kinase. (1118 aa)
GEN1Uncharacterized protein. (218 aa)
PLK1Polo like kinase 1. (477 aa)
RIOK2RIO domain-containing protein. (556 aa)
BCL7ABAF chromatin remodeling complex subunit BCL7A. (181 aa)
TEX14Testis expressed 14, intercellular bridge forming factor. (1478 aa)
MAD2L1Mitotic arrest deficient 2 like 1. (205 aa)
TRIP13Thyroid hormone receptor interactor 13; Belongs to the AAA ATPase family. (413 aa)
USP44Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (716 aa)
CDC16Cell division cycle 16. (623 aa)
PSMG2Proteasome assembly chaperone 2; Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG1. Belongs to the PSMG2 family. (265 aa)
G3W9F2_SARHAUncharacterized protein. (224 aa)
BUB3BUB3 mitotic checkpoint protein. (328 aa)
BCL7CBAF chromatin remodeling complex subunit BCL7C. (218 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3068 aa)
CDC23Cell division cycle 23. (595 aa)
KNTC1Kinetochore associated 1. (2215 aa)
BUB1BBUB1 N-terminal domain-containing protein. (1066 aa)
CDC6Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (556 aa)
ZW10Zw10 kinetochore protein. (779 aa)
RB1RB transcriptional corepressor 1. (848 aa)
ZNF207Zinc finger protein 207. (485 aa)
BIRC5Baculoviral IAP repeat containing 5. (142 aa)
Your Current Organism:
Sarcophilus harrisii
NCBI taxonomy Id: 9305
Other names: S. harrisii, Sarcophilus laniarius, Tasmanian devil
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