(62 nodes) Regulation of axon extension network (Sarcophilus harrisii)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	G3W3P2_SARHA	Uncharacterized protein. (254 aa)
	ADNP	Activity dependent neuroprotector homeobox. (1112 aa)
	RTN4R	Reticulon 4 receptor. (484 aa)
	IFRD2	Interferon related developmental regulator 2. (487 aa)
	SEMA3B	Semaphorin 3B; Belongs to the semaphorin family. (768 aa)
	SLIT1	Slit guidance ligand 1. (1397 aa)
	SEMA3F	Semaphorin 3F; Belongs to the semaphorin family. (794 aa)
	RUFY3	RUN and FYVE domain containing 3. (676 aa)
	ZFYVE27	Zinc finger FYVE-type containing 27. (403 aa)
	OLFM1	Olfactomedin 1. (485 aa)
	SHTN1	Uncharacterized protein. (303 aa)
	MAPT	Microtubule-associated protein. (711 aa)
	SEMA4F	Ssemaphorin 4F; Belongs to the semaphorin family. (733 aa)
	BARHL2	BarH like homeobox 2. (377 aa)
	RYK	Receptor like tyrosine kinase. (531 aa)
	NRP1	Neuropilin; Belongs to the neuropilin family. (857 aa)
	WNT3	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
	TNR	Tenascin R. (1358 aa)
	DBN1	Drebrin 1. (693 aa)
	IFRD1	Interferon related developmental regulator 1. (450 aa)
	SEMA7A	Semaphorin 7A (John Milton Hagen blood group); Belongs to the semaphorin family. (480 aa)
	WNT3A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (248 aa)
	SEMA4A	Semaphorin 4A; Belongs to the semaphorin family. (759 aa)
	SEMA4G	Semaphorin 4G; Belongs to the semaphorin family. (840 aa)
	SEMA6C	Semaphorin 6C; Belongs to the semaphorin family. (602 aa)
	TRPV2	Transient receptor potential cation channel subfamily V member 2; Belongs to the transient receptor (TC 1.A.4) family. (753 aa)
	SEMA6D	Semaphorin 6D; Belongs to the semaphorin family. (1022 aa)
	SRF	Serum response factor. (306 aa)
	GOLGA4	Golgin A4. (2102 aa)
	G3WCM7_SARHA	Uncharacterized protein; Belongs to the semaphorin family. (590 aa)
	SEMA6A	Semaphorin 6A; Belongs to the semaphorin family. (1029 aa)
	SEMA4B	Semaphorin 4B; Belongs to the semaphorin family. (823 aa)
	MAP1B	Uncharacterized protein. (2223 aa)
	G3W8M0_SARHA	Uncharacterized protein. (323 aa)
	BMPR2	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1042 aa)
	DRAXIN	Draxin; Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta-catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway. (338 aa)
	CDK5	Cyclin dependent kinase 5. (307 aa)
	G3W731_SARHA	Uncharacterized protein. (178 aa)
	FN1	Fibronectin 1. (2302 aa)
	ANAPC2	Anaphase promoting complex subunit 2; Belongs to the cullin family. (786 aa)
	SEMA3D	Semaphorin 3D; Belongs to the semaphorin family. (777 aa)
	SEMA5B	Semaphorin 5B. (1108 aa)
	MAP2	Microtubule-associated protein. (1790 aa)
	TRIM46	Tripartite motif containing 46. (759 aa)
	CDKL5	Cyclin dependent kinase like 5. (923 aa)
	RTN4	Reticulon. (1023 aa)
	MAG	Myelin associated glycoprotein. (559 aa)
	DIP2B	Disco interacting protein 2 homolog B. (1527 aa)
	CYFIP1	Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1265 aa)
	SEMA3C	Semaphorin 3C; Belongs to the semaphorin family. (753 aa)
	ARHGAP4	Rho GTPase activating protein 4. (936 aa)
	SEMA4D	Semaphorin 4D; Belongs to the semaphorin family. (876 aa)
	SEMA6B	Semaphorin 6B; Belongs to the semaphorin family. (668 aa)
	G3VMP4_SARHA	Uncharacterized protein. (482 aa)
	DBNL	Drebrin like. (430 aa)
	L1CAM	L1 cell adhesion molecule. (1260 aa)
	DISC1	Uncharacterized protein. (366 aa)
	LIMK1	LIM domain kinase 1. (576 aa)
	G3VEX3_SARHA	Uncharacterized protein. (106 aa)
	SEMA3E	Semaphorin 3E; Belongs to the semaphorin family. (737 aa)
	LOC100924537	Semaphorin 5A. (617 aa)
	G3VAX5_SARHA	Uncharacterized protein. (1197 aa)

Your Current Organism:

Sarcophilus harrisii

NCBI taxonomy Id: 9305
Other names: S. harrisii, Sarcophilus laniarius, Tasmanian devil

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structured XML interaction data, according to the 'PSI-MI' data standard

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BMPR2	LIMK1	ENSSHAP00000011390	ENSSHAP00000002411	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	LIM domain kinase 1.	0.567
CDK5	G3VEX3_SARHA	ENSSHAP00000011283	ENSSHAP00000001727	Cyclin dependent kinase 5.	Uncharacterized protein.	0.641
CDK5	MAP2	ENSSHAP00000011283	ENSSHAP00000009796	Cyclin dependent kinase 5.	Microtubule-associated protein.	0.641
CDK5	MAPT	ENSSHAP00000011283	ENSSHAP00000019981	Cyclin dependent kinase 5.	Microtubule-associated protein.	0.850
CDK5	NRP1	ENSSHAP00000011283	ENSSHAP00000017801	Cyclin dependent kinase 5.	Neuropilin; Belongs to the neuropilin family.	0.627
CDK5	SEMA3B	ENSSHAP00000011283	ENSSHAP00000022043	Cyclin dependent kinase 5.	Semaphorin 3B; Belongs to the semaphorin family.	0.632
DISC1	G3W731_SARHA	ENSSHAP00000002873	ENSSHAP00000011236	Uncharacterized protein.	Uncharacterized protein.	0.697
G3VEX3_SARHA	CDK5	ENSSHAP00000001727	ENSSHAP00000011283	Uncharacterized protein.	Cyclin dependent kinase 5.	0.641
G3VEX3_SARHA	MAP2	ENSSHAP00000001727	ENSSHAP00000009796	Uncharacterized protein.	Microtubule-associated protein.	0.914
G3VMP4_SARHA	RUFY3	ENSSHAP00000004449	ENSSHAP00000021570	Uncharacterized protein.	RUN and FYVE domain containing 3.	0.457
G3W3P2_SARHA	LOC100924537	ENSSHAP00000010047	ENSSHAP00000001095	Uncharacterized protein.	Semaphorin 5A.	0.894
G3W3P2_SARHA	NRP1	ENSSHAP00000010047	ENSSHAP00000017801	Uncharacterized protein.	Neuropilin; Belongs to the neuropilin family.	0.603
G3W3P2_SARHA	SEMA6B	ENSSHAP00000010047	ENSSHAP00000005379	Uncharacterized protein.	Semaphorin 6B; Belongs to the semaphorin family.	0.409
G3W3P2_SARHA	SEMA6C	ENSSHAP00000010047	ENSSHAP00000015993	Uncharacterized protein.	Semaphorin 6C; Belongs to the semaphorin family.	0.446
G3W731_SARHA	DISC1	ENSSHAP00000011236	ENSSHAP00000002873	Uncharacterized protein.	Uncharacterized protein.	0.697
L1CAM	MAP1B	ENSSHAP00000003728	ENSSHAP00000012450	L1 cell adhesion molecule.	Uncharacterized protein.	0.491
L1CAM	MAP2	ENSSHAP00000003728	ENSSHAP00000009796	L1 cell adhesion molecule.	Microtubule-associated protein.	0.427
L1CAM	NRP1	ENSSHAP00000003728	ENSSHAP00000017801	L1 cell adhesion molecule.	Neuropilin; Belongs to the neuropilin family.	0.986
L1CAM	SEMA3E	ENSSHAP00000003728	ENSSHAP00000001578	L1 cell adhesion molecule.	Semaphorin 3E; Belongs to the semaphorin family.	0.423
L1CAM	SHTN1	ENSSHAP00000003728	ENSSHAP00000020341	L1 cell adhesion molecule.	Uncharacterized protein.	0.751