(15 nodes) Thyroid gland development network (Sarcophilus harrisii)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	EDNRA	Endothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
	MAPK1	Mitogen-activated protein kinase. (348 aa)
	NKX2-5	Homeobox domain-containing protein. (320 aa)
	MAPK3	Mitogen-activated protein kinase. (375 aa)
	PAX8	Paired box 8. (457 aa)
	HOXB3	Homeobox B3. (426 aa)
	HESX1	HESX homeobox 1. (189 aa)
	SRF	Serum response factor. (306 aa)
	TG	Thyroglobulin. (2428 aa)
	THRA	Thyroid hormone receptor alpha. (408 aa)
	EDN1	Endothelin 1. (214 aa)
	BRAF	B-Raf proto-oncogene, serine/threonine kinase. (716 aa)
	HOXD3	Homeobox D3. (430 aa)
	HOXA5	Homeobox A5. (271 aa)
	HOXA3	Homeobox A3. (443 aa)

Your Current Organism:

Sarcophilus harrisii

NCBI taxonomy Id: 9305
Other names: S. harrisii, Sarcophilus laniarius, Tasmanian devil

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BRAF	MAPK1	ENSSHAP00000018862	ENSSHAP00000008915	B-Raf proto-oncogene, serine/threonine kinase.	Mitogen-activated protein kinase.	0.594
BRAF	MAPK3	ENSSHAP00000018862	ENSSHAP00000012745	B-Raf proto-oncogene, serine/threonine kinase.	Mitogen-activated protein kinase.	0.594
EDN1	EDNRA	ENSSHAP00000017819	ENSSHAP00000007913	Endothelin 1.	Endothelin receptor type A; Belongs to the G-protein coupled receptor 1 family.	0.998
EDNRA	EDN1	ENSSHAP00000007913	ENSSHAP00000017819	Endothelin receptor type A; Belongs to the G-protein coupled receptor 1 family.	Endothelin 1.	0.998
HOXA3	HOXA5	ENSSHAP00000019775	ENSSHAP00000019695	Homeobox A3.	Homeobox A5.	0.696
HOXA5	HOXA3	ENSSHAP00000019695	ENSSHAP00000019775	Homeobox A5.	Homeobox A3.	0.696
MAPK1	BRAF	ENSSHAP00000008915	ENSSHAP00000018862	Mitogen-activated protein kinase.	B-Raf proto-oncogene, serine/threonine kinase.	0.594
MAPK1	MAPK3	ENSSHAP00000008915	ENSSHAP00000012745	Mitogen-activated protein kinase.	Mitogen-activated protein kinase.	0.901
MAPK3	BRAF	ENSSHAP00000012745	ENSSHAP00000018862	Mitogen-activated protein kinase.	B-Raf proto-oncogene, serine/threonine kinase.	0.594
MAPK3	MAPK1	ENSSHAP00000012745	ENSSHAP00000008915	Mitogen-activated protein kinase.	Mitogen-activated protein kinase.	0.901
NKX2-5	SRF	ENSSHAP00000010277	ENSSHAP00000014927	Homeobox domain-containing protein.	Serum response factor.	0.668
PAX8	TG	ENSSHAP00000013853	ENSSHAP00000015824	Paired box 8.	Thyroglobulin.	0.561
SRF	NKX2-5	ENSSHAP00000014927	ENSSHAP00000010277	Serum response factor.	Homeobox domain-containing protein.	0.668
TG	PAX8	ENSSHAP00000015824	ENSSHAP00000013853	Thyroglobulin.	Paired box 8.	0.561