(60 nodes) Positive regulation of peptidyl-serine phosphorylation network (Sarcophilus harrisii)

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second shell of interactors

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proteins of unknown 3D structure

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experimentally determined

Predicted Interactions

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protein homology

Your Input:
	ERCC6	ERCC excision repair 6, chromatin remodeling factor. (1474 aa)
	PTGS2	Prostaglandin-endoperoxide synthase 2. (609 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1069 aa)
	TENM1	Teneurin transmembrane protein 1. (2038 aa)
	NTRK3	Tyrosine-protein kinase receptor. (825 aa)
	BAG4	BCL2 associated athanogene 4. (373 aa)
	LATS1	Large tumor suppressor kinase 1. (1134 aa)
	LOC100914443	Uncharacterized protein. (187 aa)
	BCL2	BCL2 apoptosis regulator. (227 aa)
	SH2D3C	SH2 domain containing 3C. (868 aa)
	G3VBM8_SARHA	Uncharacterized protein. (128 aa)
	G3VDB1_SARHA	UBP-type domain-containing protein. (1054 aa)
	APP	Amyloid beta precursor protein. (750 aa)
	ATP2B4	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1250 aa)
	AXIN1	Axin 1. (875 aa)
	FNIP1	Folliculin interacting protein 1. (1114 aa)
	BCAR3	BCAR3 adaptor protein, NSP family member. (827 aa)
	CAPRIN2	Caprin family member 2. (1067 aa)
	SH2D3A	SH2 domain containing 3A. (653 aa)
	G3VPS2_SARHA	PP1c_bdg domain-containing protein. (199 aa)
	MTCP1	Mature T cell proliferation 1. (108 aa)
	RAPGEF3	Rap guanine nucleotide exchange factor 3. (926 aa)
	MAPKAP1	MAPK associated protein 1. (522 aa)
	PDCD10	Programmed cell death 10. (212 aa)
	TFRC	Transferrin receptor. (770 aa)
	ARAF	A-Raf proto-oncogene, serine/threonine kinase. (627 aa)
	STOX1	Stork_head domain-containing protein. (897 aa)
	TGFB1	TGF_BETA_2 domain-containing protein. (162 aa)
	SFRP2	Secreted frizzled related protein 2. (238 aa)
	NTF3	Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (268 aa)
	PINK1	PTEN induced kinase 1. (453 aa)
	EGFR	Receptor protein-tyrosine kinase. (1152 aa)
	NOS1	Nitric oxide synthase; Produces nitric oxide (NO). (1152 aa)
	RPTOR	Regulatory associated protein of MTOR complex 1. (1056 aa)
	LIF	LIF interleukin 6 family cytokine. (202 aa)
	MAD2L2	Mitotic arrest deficient 2 like 2. (159 aa)
	RET	Ret proto-oncogene; Belongs to the protein kinase superfamily. Tyr protein kinase family. (894 aa)
	OPRD1	Opioid receptor delta 1; Belongs to the G-protein coupled receptor 1 family. (308 aa)
	HCLS1	Hematopoietic cell-specific Lyn substrate 1. (558 aa)
	RAF1	Raf-1 proto-oncogene, serine/threonine kinase. (647 aa)
	CREBL2	cAMP responsive element binding protein like 2. (123 aa)
	FNIP2	Folliculin interacting protein 2. (839 aa)
	NGF	Nerve growth factor; Belongs to the NGF-beta family. (284 aa)
	HAX1	HCLS1-associated protein X-1; Recruits the Arp2/3 complex to the cell cortex and regulates reorganization of the cortical actin cytoskeleton via its interaction with KCNC3 and the Arp2/3 complex. Slows down the rate of inactivation of KCNC3 channels. Promotes GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. Promotes cell survival. May regulate intracellular calcium pools. (277 aa)
	UCN	Urocortin. (129 aa)
	RAMP3	Receptor activity modifying protein 3. (149 aa)
	CSF3	Colony stimulating factor 3. (221 aa)
	GAS6	Growth arrest specific 6. (677 aa)
	SMYD3	SET domain-containing protein. (270 aa)
	NTRK2	Ig-like domain-containing protein. (310 aa)
	TNKS1BP1	Tankyrase_bdg_C domain-containing protein. (1862 aa)
	RIPK2	Receptor interacting serine/threonine kinase 2. (541 aa)
	BDNF	Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. (246 aa)
	IFNG	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (167 aa)
	CAV1	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (188 aa)
	CAMK1	Calcium/calmodulin dependent protein kinase I; Belongs to the protein kinase superfamily. (370 aa)
	IL6	Uncharacterized protein. (212 aa)
	CNOT9	CCR4-NOT transcription complex subunit 9. (329 aa)
	PARK7	Parkinsonism associated deglycase. (192 aa)
	BRAF	B-Raf proto-oncogene, serine/threonine kinase. (716 aa)

Your Current Organism:

Sarcophilus harrisii

NCBI taxonomy Id: 9305
Other names: S. harrisii, Sarcophilus laniarius, Tasmanian devil

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APP	BDNF	ENSSHAP00000002408	ENSSHAP00000017094	Amyloid beta precursor protein.	Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS.	0.520
APP	EGFR	ENSSHAP00000002408	ENSSHAP00000009645	Amyloid beta precursor protein.	Receptor protein-tyrosine kinase.	0.471
APP	IL6	ENSSHAP00000002408	ENSSHAP00000013156	Amyloid beta precursor protein.	Uncharacterized protein.	0.405
APP	TGFB1	ENSSHAP00000002408	ENSSHAP00000007275	Amyloid beta precursor protein.	TGF_BETA_2 domain-containing protein.	0.510
ARAF	BRAF	ENSSHAP00000007169	ENSSHAP00000018862	A-Raf proto-oncogene, serine/threonine kinase.	B-Raf proto-oncogene, serine/threonine kinase.	0.830
ARAF	RAF1	ENSSHAP00000007169	ENSSHAP00000012974	A-Raf proto-oncogene, serine/threonine kinase.	Raf-1 proto-oncogene, serine/threonine kinase.	0.902
ATP2B4	NOS1	ENSSHAP00000004061	ENSSHAP00000009708	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	Nitric oxide synthase; Produces nitric oxide (NO).	0.561
AXIN1	CAV1	ENSSHAP00000004359	ENSSHAP00000017975	Axin 1.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.418
AXIN1	SFRP2	ENSSHAP00000004359	ENSSHAP00000007535	Axin 1.	Secreted frizzled related protein 2.	0.430
BCL2	BDNF	ENSSHAP00000020974	ENSSHAP00000017094	BCL2 apoptosis regulator.	Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS.	0.578
BCL2	BRAF	ENSSHAP00000020974	ENSSHAP00000018862	BCL2 apoptosis regulator.	B-Raf proto-oncogene, serine/threonine kinase.	0.494
BCL2	EGFR	ENSSHAP00000020974	ENSSHAP00000009645	BCL2 apoptosis regulator.	Receptor protein-tyrosine kinase.	0.526
BCL2	IFNG	ENSSHAP00000020974	ENSSHAP00000017704	BCL2 apoptosis regulator.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.456
BCL2	IL6	ENSSHAP00000020974	ENSSHAP00000013156	BCL2 apoptosis regulator.	Uncharacterized protein.	0.542
BCL2	PTGS2	ENSSHAP00000020974	ENSSHAP00000019049	BCL2 apoptosis regulator.	Prostaglandin-endoperoxide synthase 2.	0.461
BDNF	APP	ENSSHAP00000017094	ENSSHAP00000002408	Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS.	Amyloid beta precursor protein.	0.520
BDNF	BCL2	ENSSHAP00000017094	ENSSHAP00000020974	Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS.	BCL2 apoptosis regulator.	0.578
BDNF	IL6	ENSSHAP00000017094	ENSSHAP00000013156	Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS.	Uncharacterized protein.	0.660
BDNF	NTF3	ENSSHAP00000017094	ENSSHAP00000007737	Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS.	Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family.	0.912
BDNF	NTRK2	ENSSHAP00000017094	ENSSHAP00000016814	Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS.	Ig-like domain-containing protein.	0.981