(29 nodes) Cellular response to vascular endothelial growth factor stimulus network (Sarcophilus harrisii)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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Predicted Interactions

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Your Input:
	DAB2IP	DAB2 interacting protein. (783 aa)
	MAPKAPK2	MAPK activated protein kinase 2. (307 aa)
	PDGFRB	Platelet derived growth factor receptor beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1092 aa)
	SPHK1	Sphingosine kinase 1. (453 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1069 aa)
	DLL4	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (691 aa)
	NRP1	Neuropilin; Belongs to the neuropilin family. (857 aa)
	ERN1	Endoplasmic reticulum to nucleus signaling 1. (922 aa)
	NUS1	NUS1 dehydrodolichyl diphosphate synthase subunit. (244 aa)
	VEGFC	Uncharacterized protein. (236 aa)
	G3WKE1_SARHA	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (134 aa)
	PDGFRA	Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1101 aa)
	NR4A1	Nuclear receptor subfamily 4 group A member 1. (652 aa)
	HSPB1	Heat shock protein family B (small) member 1; Belongs to the small heat shock protein (HSP20) family. (218 aa)
	SEMA6A	Semaphorin 6A; Belongs to the semaphorin family. (1029 aa)
	XBP1	BZIP domain-containing protein. (308 aa)
	ANXA1	Annexin. (346 aa)
	GAB1	GRB2 associated binding protein 1. (694 aa)
	KDR	Kinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1349 aa)
	PGF	Placental growth factor; Belongs to the PDGF/VEGF growth factor family. (170 aa)
	ITGB1BP1	Integrin subunit beta 1 binding protein 1. (203 aa)
	FLT4	Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
	NOTCH1	Notch receptor 1. (2672 aa)
	RELA	RELA proto-oncogene, NF-kB subunit. (483 aa)
	MYO1C	Myosin IC; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1052 aa)
	LOC100921027	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1183 aa)
	EGR3	Early growth response 3. (277 aa)
	NRP2	Neuropilin; Belongs to the neuropilin family. (929 aa)
	FLT1	Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1341 aa)

Your Current Organism:

Sarcophilus harrisii

NCBI taxonomy Id: 9305
Other names: S. harrisii, Sarcophilus laniarius, Tasmanian devil

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DLL4	FLT1	ENSSHAP00000019124	ENSSHAP00000021496	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.410
DLL4	FLT4	ENSSHAP00000019124	ENSSHAP00000008479	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.495
DLL4	KDR	ENSSHAP00000019124	ENSSHAP00000009807	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Kinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.460
DLL4	NOTCH1	ENSSHAP00000019124	ENSSHAP00000005642	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Notch receptor 1.	0.961
EGR3	NR4A1	ENSSHAP00000022048	ENSSHAP00000014809	Early growth response 3.	Nuclear receptor subfamily 4 group A member 1.	0.465
ERN1	XBP1	ENSSHAP00000016597	ENSSHAP00000012615	Endoplasmic reticulum to nucleus signaling 1.	BZIP domain-containing protein.	0.970
FLT1	DLL4	ENSSHAP00000021496	ENSSHAP00000019124	Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.410
FLT1	FLT4	ENSSHAP00000021496	ENSSHAP00000008479	Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.565
FLT1	G3WKE1_SARHA	ENSSHAP00000021496	ENSSHAP00000015896	Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family.	0.707
FLT1	LOC100921027	ENSSHAP00000021496	ENSSHAP00000000718	Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.904
FLT1	NRP1	ENSSHAP00000021496	ENSSHAP00000017801	Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	Neuropilin; Belongs to the neuropilin family.	0.865
FLT1	NRP2	ENSSHAP00000021496	ENSSHAP00000021634	Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	Neuropilin; Belongs to the neuropilin family.	0.837
FLT1	PDGFRB	ENSSHAP00000021496	ENSSHAP00000020111	Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	Platelet derived growth factor receptor beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.591
FLT1	PGF	ENSSHAP00000021496	ENSSHAP00000021472	Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	Placental growth factor; Belongs to the PDGF/VEGF growth factor family.	0.986
FLT1	PIK3CA	ENSSHAP00000021496	ENSSHAP00000019318	Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.806
FLT1	VEGFC	ENSSHAP00000021496	ENSSHAP00000016012	Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	Uncharacterized protein.	0.948
FLT4	DLL4	ENSSHAP00000008479	ENSSHAP00000019124	Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.495
FLT4	FLT1	ENSSHAP00000008479	ENSSHAP00000021496	Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.565
FLT4	G3WKE1_SARHA	ENSSHAP00000008479	ENSSHAP00000015896	Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family.	0.912
FLT4	LOC100921027	ENSSHAP00000008479	ENSSHAP00000000718	Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.444