(68 nodes) Positive regulation of T cell differentiation network (Sarcophilus harrisii)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	EGR3	Early growth response 3. (277 aa)
	G3VCP0_SARHA	AIG1-type G domain-containing protein. (235 aa)
	G3VDT8_SARHA	Amine oxidase. (534 aa)
	SYK	Tyrosine-protein kinase. (466 aa)
	IL23A	Interleukin 23 subunit alpha. (195 aa)
	G3VFP8_SARHA	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (245 aa)
	KAT5	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (481 aa)
	WNT10B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
	FOXP3	Forkhead box P3. (408 aa)
	HLA-DRA	Major histocompatibility complex, class II, DR alpha; Belongs to the MHC class II family. (262 aa)
	LEF1	Lymphoid enhancer binding factor 1. (256 aa)
	G3VL75_SARHA	Uncharacterized protein. (816 aa)
	IL2RG	Fibronectin type-III domain-containing protein. (387 aa)
	ZAP70	Zeta chain of T cell receptor associated protein kinase 70. (648 aa)
	SOX12	Transcription factor SOX. (326 aa)
	G3VQB9_SARHA	Amino_oxidase domain-containing protein. (286 aa)
	ZBTB7B	Zinc finger and BTB domain containing 7B. (529 aa)
	BAD	Uncharacterized protein. (173 aa)
	TGFB1	TGF_BETA_2 domain-containing protein. (162 aa)
	NFKBIZ	NFKB inhibitor zeta. (704 aa)
	IL7R	Fibronectin type-III domain-containing protein. (454 aa)
	TESPA1	Thymocyte expressed, positive selection associated 1. (502 aa)
	SOX13	SRY-box transcription factor 13. (617 aa)
	ITPKB	Kinase; Belongs to the inositol phosphokinase (IPK) family. (298 aa)
	ADA	Adenosine deaminase. (364 aa)
	G3W510_SARHA	Kinase; Belongs to the inositol phosphokinase (IPK) family. (650 aa)
	SOCS5	Suppressor of cytokine signaling 5. (539 aa)
	G3W5R5_SARHA	Uncharacterized protein. (115 aa)
	GLI3	GLI family zinc finger 3. (1583 aa)
	ZBTB16	Zinc finger and BTB domain containing 16. (674 aa)
	CBFB	Core-binding factor subunit beta. (185 aa)
	ANXA1	Annexin. (346 aa)
	NFKBID	NFKB inhibitor delta. (324 aa)
	ZBTB1	Zinc finger and BTB domain containing 1. (713 aa)
	LOC111718724	Interleukin-1. (160 aa)
	DUSP10	Dual specificity phosphatase 10. (482 aa)
	XBP1	BZIP domain-containing protein. (308 aa)
	SOX4	Transcription factor SOX. (355 aa)
	SART1	Spliceosome associated factor 1, recruiter of U4/U6.U5 tri-snRNP. (772 aa)
	G3WE02_SARHA	Uncharacterized protein. (212 aa)
	IL4	Uncharacterized protein. (156 aa)
	G3WEP2_SARHA	Uncharacterized protein. (212 aa)
	NCKAP1L	NCK associated protein 1 like. (1136 aa)
	SOX11	Transcription factor SOX. (444 aa)
	HLX	H2.0 like homeobox. (499 aa)
	G3WFT8_SARHA	Uncharacterized protein. (466 aa)
	IL18	Uncharacterized protein. (201 aa)
	TGFBR2	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (409 aa)
	PCK1	Phosphoenolpyruvate carboxykinase 1. (624 aa)
	BCL6	BCL6 transcription repressor. (692 aa)
	SOCS1	Suppressor of cytokine signaling 1. (154 aa)
	RAG1	V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T- lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break [...] (1047 aa)
	IHH	Indian hedgehog signaling molecule. (310 aa)
	RIPK2	Receptor interacting serine/threonine kinase 2. (541 aa)
	MYB	MYB proto-oncogene, transcription factor. (760 aa)
	CD27	Uncharacterized protein. (271 aa)
	SASH3	SAM and SH3 domain containing 3. (415 aa)
	CD83	Ig-like domain-containing protein. (209 aa)
	IFNG	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (167 aa)
	MALT1	MALT1 paracaspase. (753 aa)
	PTPRC	Uncharacterized protein. (1311 aa)
	SHH	HintN domain-containing protein. (278 aa)
	AMBRA1	Autophagy and beclin 1 regulator 1. (1290 aa)
	ZMIZ1	Zinc finger MIZ-type containing 1. (980 aa)
	AP3B1	AP-3 complex subunit beta; Belongs to the adaptor complexes large subunit family. (1086 aa)
	RHOH	Ras homolog family member H. (191 aa)
	GATA3	GATA binding protein 3. (444 aa)
	RASGRP1	RAS guanyl releasing protein 1. (726 aa)

Your Current Organism:

Sarcophilus harrisii

NCBI taxonomy Id: 9305
Other names: S. harrisii, Sarcophilus laniarius, Tasmanian devil

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BCL6	FOXP3	ENSSHAP00000016376	ENSSHAP00000003022	BCL6 transcription repressor.	Forkhead box P3.	0.627
BCL6	IL4	ENSSHAP00000016376	ENSSHAP00000013845	BCL6 transcription repressor.	Uncharacterized protein.	0.672
BCL6	RHOH	ENSSHAP00000016376	ENSSHAP00000021172	BCL6 transcription repressor.	Ras homolog family member H.	0.460
CBFB	FOXP3	ENSSHAP00000011587	ENSSHAP00000003022	Core-binding factor subunit beta.	Forkhead box P3.	0.646
CBFB	GATA3	ENSSHAP00000011587	ENSSHAP00000021668	Core-binding factor subunit beta.	GATA binding protein 3.	0.626
CD27	FOXP3	ENSSHAP00000017348	ENSSHAP00000003022	Uncharacterized protein.	Forkhead box P3.	0.420
CD27	G3VFP8_SARHA	ENSSHAP00000017348	ENSSHAP00000002002	Uncharacterized protein.	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family.	0.660
CD27	IFNG	ENSSHAP00000017348	ENSSHAP00000017704	Uncharacterized protein.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.522
CD27	IL7R	ENSSHAP00000017348	ENSSHAP00000007828	Uncharacterized protein.	Fibronectin type-III domain-containing protein.	0.491
CD27	PTPRC	ENSSHAP00000017348	ENSSHAP00000018286	Uncharacterized protein.	Uncharacterized protein.	0.414
CD83	IFNG	ENSSHAP00000017596	ENSSHAP00000017704	Ig-like domain-containing protein.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.414
CD83	IL4	ENSSHAP00000017596	ENSSHAP00000013845	Ig-like domain-containing protein.	Uncharacterized protein.	0.461
FOXP3	BCL6	ENSSHAP00000003022	ENSSHAP00000016376	Forkhead box P3.	BCL6 transcription repressor.	0.627
FOXP3	CBFB	ENSSHAP00000003022	ENSSHAP00000011587	Forkhead box P3.	Core-binding factor subunit beta.	0.646
FOXP3	CD27	ENSSHAP00000003022	ENSSHAP00000017348	Forkhead box P3.	Uncharacterized protein.	0.420
FOXP3	GATA3	ENSSHAP00000003022	ENSSHAP00000021668	Forkhead box P3.	GATA binding protein 3.	0.717
FOXP3	IFNG	ENSSHAP00000003022	ENSSHAP00000017704	Forkhead box P3.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.751
FOXP3	IL4	ENSSHAP00000003022	ENSSHAP00000013845	Forkhead box P3.	Uncharacterized protein.	0.633
FOXP3	IL7R	ENSSHAP00000003022	ENSSHAP00000007828	Forkhead box P3.	Fibronectin type-III domain-containing protein.	0.529
FOXP3	KAT5	ENSSHAP00000003022	ENSSHAP00000002166	Forkhead box P3.	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family.	0.714