(10 nodes) Positive regulation of keratinocyte differentiation network (Sarcophilus harrisii)

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Your Input:
	MED1	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1573 aa)
	NCOA3	Nuclear receptor coactivator 3. (1326 aa)
	ALOX15B	Arachidonate 15-lipoxygenase type B. (732 aa)
	CYP27B1	Cytochrome P450 family 27 subfamily B member 1; Belongs to the cytochrome P450 family. (508 aa)
	MACROH2A1	Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. (372 aa)
	CYP27C1	Cytochrome P450 family 27 subfamily C member 1; Belongs to the cytochrome P450 family. (443 aa)
	MACROH2A2	Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. (372 aa)
	NUMA1	Nuclear mitotic apparatus protein 1. (2096 aa)
	VDR	Vitamin D receptor. (338 aa)
	NOTCH1	Notch receptor 1. (2672 aa)

Your Current Organism:

Sarcophilus harrisii

NCBI taxonomy Id: 9305
Other names: S. harrisii, Sarcophilus laniarius, Tasmanian devil

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CYP27B1	MED1	ENSSHAP00000011013	ENSSHAP00000018877	Cytochrome P450 family 27 subfamily B member 1; Belongs to the cytochrome P450 family.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.518
CYP27B1	VDR	ENSSHAP00000011013	ENSSHAP00000001132	Cytochrome P450 family 27 subfamily B member 1; Belongs to the cytochrome P450 family.	Vitamin D receptor.	0.445
CYP27C1	MED1	ENSSHAP00000009389	ENSSHAP00000018877	Cytochrome P450 family 27 subfamily C member 1; Belongs to the cytochrome P450 family.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.518
CYP27C1	VDR	ENSSHAP00000009389	ENSSHAP00000001132	Cytochrome P450 family 27 subfamily C member 1; Belongs to the cytochrome P450 family.	Vitamin D receptor.	0.445
MED1	CYP27B1	ENSSHAP00000018877	ENSSHAP00000011013	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	Cytochrome P450 family 27 subfamily B member 1; Belongs to the cytochrome P450 family.	0.518
MED1	CYP27C1	ENSSHAP00000018877	ENSSHAP00000009389	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	Cytochrome P450 family 27 subfamily C member 1; Belongs to the cytochrome P450 family.	0.518
MED1	NCOA3	ENSSHAP00000018877	ENSSHAP00000018558	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	Nuclear receptor coactivator 3.	0.962
MED1	VDR	ENSSHAP00000018877	ENSSHAP00000001132	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	Vitamin D receptor.	0.819
NCOA3	MED1	ENSSHAP00000018558	ENSSHAP00000018877	Nuclear receptor coactivator 3.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.962
NCOA3	VDR	ENSSHAP00000018558	ENSSHAP00000001132	Nuclear receptor coactivator 3.	Vitamin D receptor.	0.778
VDR	CYP27B1	ENSSHAP00000001132	ENSSHAP00000011013	Vitamin D receptor.	Cytochrome P450 family 27 subfamily B member 1; Belongs to the cytochrome P450 family.	0.445
VDR	CYP27C1	ENSSHAP00000001132	ENSSHAP00000009389	Vitamin D receptor.	Cytochrome P450 family 27 subfamily C member 1; Belongs to the cytochrome P450 family.	0.445
VDR	MED1	ENSSHAP00000001132	ENSSHAP00000018877	Vitamin D receptor.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.819
VDR	NCOA3	ENSSHAP00000001132	ENSSHAP00000018558	Vitamin D receptor.	Nuclear receptor coactivator 3.	0.778